Evidence for a regulatory loop between cholecystokinin (CCK) and tryptic enzyme activity in Atlantic cod larvae (Gadus morhua)

Effects of dietary size-fractionated fish hydrolysates on growth, activities of digestive enzymes and aminotransferases and expression of some protein metabolism related genes in large yellow croaker (Larimichthys crocea) larvae

“…Indeed, better secretory function of pancreas of fish in the control group than NUFH-40 group and RUFH-40 group could be due to relatively higher expression of CCK gene. Previous study has demonstrated that in fish, as well as in mammals, CCK is critical in the stimulation of pancreatic enzyme secretion and can affect digestion by altering the expression of trypsin (Cahu et al, 2004;Furutani et al, 2013;Murashita et al, 2007;Rojas-García and Rønnestad, 2002;Tillner et al, 2013). In the current study, mRNA levels of CCK and trypsin correlated well with the change of the ratio of trypsin (I)/trypsin (P).…”

Optimal dietary alpha-linolenic acid/linoleic acid ratio improved digestive and absorptive capacities and target of rapamycin gene expression of juvenile grass carp (Ctenopharyngodon idellus)

“…Moreover, CCK could stimulate trypsin secretion, thereby enhance its activity in the hepatopancreas of Atlantic cod ( Gadus morhua ) (Tillner et al . ). These data indicated that dietary ALA and LNA may affect the digestive enzyme activities in fish.…”

Growth performance, digestive and absorptive capacity of on‐growing grass carp ( Ctenopharyngodon idellus ) fed with graded level of dietary fibre from soybean hulls

“…trypsin) secretion of rats (Isaksson et al., 1983). Furthermore, cholecystokinin (CCK) is the key regulator hormone that stimulated hepatopancreatic enzyme secretion in Atlantic cod ( Gadus morhua ) (Tillner et al., 2013). In our study, the serum CCK level was not significantly increased with dietary fibre supplements, which could be partly related to CCK sensitivity.…”

“…TOR, target of rapamycin; S6K1, ribosomal protein S6 kinase 1; 4E-BP, eukaryotic initiation factor 4E binding protein; PI, proximal intestine; MI, mid intestine; DI, distal intestine. Values are means ± SD of three replicates (two fish per replicate), and different letters denote significant difference ( A,B,C p < .01 and a,b,c p < .05) is the key regulator hormone that stimulated hepatopancreatic enzyme secretion in Atlantic cod (Gadus morhua) (Tillner et al, 2013).…”