Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease.

Thomas, D. J. B.; Young, Adam; Gorsuch, A.N.; Bottazzo, G. F.; Cudworth, A G

doi:10.1136/ard.42.3.297

Cited by 74 publications

(31 citation statements)

References 13 publications

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“…All patients were females in SLE and pSS groups and comprised 88.9% in the RA group. Our data are similar to those reported for other populations [5][6][7][8][9][10] . Previous studies have shown that a number of patients with subclinical hypothyroidism will eventually develop clinical hypothyroidism [12] .…”

Section: Discussionsupporting

confidence: 82%

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Al-Awadhi

Olusi²,

Hasan³

et al. 2008

Med Princ Pract

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Objectives: The purpose of this study was to examine the frequencies of abnormal thyroid function tests and serum thyroid autoantibodies in healthy Kuwaitis and those with autoimmune diseases. Subjects and Methods: Serum concentrations of sensitive thyrotropin, and free thyroxine were measured in 577 apparently healthy controls, 177 patients with rheumatoid arthritis (RA), 60 with systemic lupus erythematosus (SLE) and 25 with primary Sjogren’s syndrome (pSS) using the immunochemiluminescent assay method on IMMULITE 1000. Serum microsomal and thyroglobulin autoantibodies were also measured by passive hemagglutination assay. For analysis of the thyroid function tests, the subjects were classified into five categories: normal, subclinical hypothyroidism, overt hypothyroidism, euthyroid sick syndrome and biochemical hyperthyroidism. Results: Subclinical hypothyroidism was seen in 1.7% of healthy controls, 10.2% of RA, 13.3% of SLE, and 16% of pSS patients. Among RA patients, the frequency of subclinical hypothyroidism in females (11.4%) was significantly higher than among males (5.4%; p < 0.01). In SLE and pSS patients, all those with subclinical hypothyroidism were females. Overt hypothyroidism was seen in 1.4% of controls, 10.2% of RA, 8.3% of SLE, and 4% of pSS patients. Biochemical hyperthyroidism was seen in 0.2% of controls, 4.5% of RA, 5% of SLE and none of pSS patients. The euthyroid sick syndrome was seen in 0.4% of controls, 13.6% of RA, 16.7% of SLE and in none of pSS patients. Thyroid autoantibodies were present in 3.1% of controls, 12.4% of RA, 18.3% of SLE, and 12% of pSS patients. Conclusion: Our data show that abnormal thyroid function tests and thyroid autoantibodies occur frequently in Ku-waitis with autoimmune diseases. Therefore, ordering these tests in these diseases is recommended.

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Section: Discussionsupporting

confidence: 82%

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Al-Awadhi

Olusi²,

Hasan³

et al. 2008

Med Princ Pract

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“…The estimated contribution to sibling risk accounted for by excess sharing at CRH was s , CRH ϭ 1.14 (17). The total sibling risk for RA is between 5 and 7.2 (19,20), indicating that CRH accounts for Ͻ10% of the sibling risk. In contrast, s , HLA ϭ 1.8 and accounts for ϳ30% of the sibling risk (2,21).…”

Section: Resultsmentioning

confidence: 99%

Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region

Fife¹,

Fisher²,

John

et al. 2000

Arthritis & Rheumatism

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“…A recent Danish population-based cohort study confirmed this association; they reported that firstdegree relatives of patients with Multiple Sclerosis had 63% increased risk for the development of Type I Diabetes (12). Controlled studies also suggest an increased prevalence of Type I Diabetes within family members of Rheumatoid Arthritis (13,14,15), an increased prevalence of autoimmune Thyroiditis within families with Type I Diabetes (16), and an increased prevalence of autoimmune Thyroiditis and Rheumatoid Arthritis within families with Idiopathic Inflammatory Myopathy (17). An increased risk of autoimmune Thyroiditis, Rheumatoid Arthritis and Systemic Lupus Erythematosus among other autoimmune diseases was also reported in families with primary Sjogren 's Syndrome (18).…”

mentioning

confidence: 95%

Epidemiology of autoimmune diseases in Denmark

Eaton¹,

Rose²,

Kalaydjian³

et al. 2007

Journal of Autoimmunity

378

299

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An epidemiologic study of the autoimmune diseases taken together has not been done heretofore. The National Patient Register of Denmark is used to estimate population prevalence of 31 possible or probable autoimmune diseases. Record linkage is used to estimate 465 pairwise comorbidities in individuals among the 31 diseases, and familial aggregation among sibs, parents and offspring. The prevalence of any of the 31 diseases in the population is more than 5%. Within individuals, there is extensive comorbidity across the 31 diseases. Within families, aggregation is strongest for individual diseases, and weak across diseases. These data confirm the importance of the autoimmune diseases as a group, and suggest that common etiopathologies exist among them.

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Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease.

Cited by 74 publications

References 13 publications

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region

Epidemiology of autoimmune diseases in Denmark

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