Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma

Lee, Jeffrey K.; Ghosh, Pradipta; McWhorter, Valerie C.; Payne, Misty; Olson, Ryan; Krinsky, Mary Lee; Ramamoorthy, Sonia; Carethers, John M.

doi:10.3748/wjg.14.4389

Cited by 20 publications

(26 citation statements)

References 27 publications

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“…The term carcinosarcoma is used to describe a rare mixed mesodermal malignancy consisting of an epithelial component most often a mid to high grade adenocarcinoma and a sarcomatous element of mesenchymal origin which may be differentiated or undifferentiated [ 1 ]. CS displays a preponderance for the female reproductive tract, most often the ovaries and uterus, but is also found within the head, neck, and respiratory and gastrointestinal tract [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The presentation and malignant behavior of CS is very similar to that of adenocarcinoma with the carcinomatous component showing a strong tendency to metastasise to lymph nodes and distant sites whereas the sarcoma plays only a very minor role in metastatic spread [ 5 ]. Patients may report symptoms such as rectal bleeding [ 1 , 6 , 7 ], weight loss [ 8 ], and abdominal pain [ 9 ] and obstructive symptoms [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most commonly observed pattern of staining is reactivity in the adenocarcinomatous component to the epithelial markers, CK20 and CEA [ 5 , 9 ]. The sarcomatous cells frequently stain positively for vimentin, desmin, and SMA [ 1 , 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Sudlow

Liu

Waters

et al. 2015

Case Reports in Surgery

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Carcinosarcoma (CS) is a rare mixed mesodermal malignancy most commonly affecting the female reproductive organs, respiratory tract, head, and neck. Though infrequent, it may affect the gastrointestinal tract, most often the oesophagus and only very rarely the rectum. Histologically, it is composed of two distinct elements of epithelial and mesenchymal origin. Clinically, it is a very aggressive tumour with many patients presenting with metastatic lymph nodes or distant metastases at the time of diagnosis. Prognosis is poor despite intervention with the majority of patients dying within six months. Due to the rarity of this condition, there are no specific treatment guidelines presently available. We describe the case of an 80-year-old patient with carcinosarcoma of the rectum with discussion of the immunohistochemistry and review the available literature pertaining to this rare presentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Sudlow

Liu

Waters

et al. 2015

Case Reports in Surgery

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“…2 However, distinguishing between these morphological variants seems to remain a shutter sophism and not a medical practice for several reasons: first of all, in most cases, the choice of the term falls on an arbitrary interpretation of the authors rather than strictly immunohistochemical features; second, many sarcomatous components were not tested for a common panel of epithelial markers (in some cases not a single marker was tested); third and most important, both SC and CS show the same dismal prognosis. [3][4][5] Digging into the world literature, including our report, we found only 35 cases of SC/CS. Of note, 25 lesions were located in the left colon and rectum and only 1 patient was underage (mean age = 67 years; Table 1).…”

Section: Dear Editormentioning

confidence: 94%

Diagnosing Sarcomatoid Carcinoma and Carcinosarcoma of the Large Bowel

et al. 2014

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“…Sarcomatoid carcinoma (SC) is an uncommon malignant neoplasm of primitive epithelial cell origin that displays both malignant epithelial and mesochymal characteristics. 5 Clinically, they are usually aggressive tumors with early occurrence of distant metastasis. To our knowledge, SCs rarely occur in the pelvic cavity, with only 1 case reported in literature.…”

Section: Introductionmentioning

confidence: 99%

Severe Hypoglycemia Caused by Recurrent Sarcomatoid Carcinoma in the Pelvic Cavity

Fang

Fan

et al. 2015

Medicine

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Nonislet cell tumor hypoglycemia (NICTH) is a paraneoplastic syndrome characterized by persistent, severe hypoglycemia in different tumor types of mesochymal or epithelial origin; however, NICTH is infrequently induced by sarcomatoid carcinoma (SC). Despite some sarcomatoid and epithelioid characteristics in few cases of malignancies from epithelium, NICTH induced by recurrent SC in pelvic cavity in this report is extremely rare.We report a case in which NICTH caused by recurrence and pulmonary metastases from SC in the pelvic cavity, and the computed tomography scan revealed multiple pelvic masses and multiple large masses in the pulmonary fields. During the treatment of intestinal obstruction, the patient presented paroxysmal loss of consciousness and sweating. Her glucose even reached 1.22 mmol/L while the serum glycosylated hemoglobin was normal and previous history of diabetes or use of oral hypoglycemic agents and insulin denied.The laboratory examination showed that the low level of insulin, C-peptide, and growth hormone levels in the course of hypoglycemic episodes suggesting to the diagnosis of hypoglycemia induced by nonislet cell tumor, and the decreased levels of insulin-like growth factor (IGF)-I and IGFBP3 and the high expression of big IGF-II in the serum further confirmed the diagnosis of NICTH. Because of the widely pelvic recurrence and pulmonary metastases were unresected, the patient was discharged from the hospital after 2 weeks treatment with dexamethasone and glucose and unfortunately died 1 week later.NICTH caused by SC in the pelvic cavity is extremely rare case in clinical. The aim of this report was to present the importance to examine big IGF-II expression in patient's serum in order to reach the diagnosis of NICTH in cases of intractable cancer-associated hypoglycemia.

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Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma

Cited by 20 publications

References 27 publications

Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Diagnosing Sarcomatoid Carcinoma and Carcinosarcoma of the Large Bowel

Severe Hypoglycemia Caused by Recurrent Sarcomatoid Carcinoma in the Pelvic Cavity

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