Evidence for involvement of the phenylpropanoid pathway in the biosynthesis of the norlignan agatharesinol

Imai, Takanori; Nomura, Masaki; Fukushima, Kazuhiko

doi:10.1016/j.jplph.2005.08.009

Cited by 30 publications

(18 citation statements)

References 9 publications

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“…These results suggest that the biosynthetic steps leading to agatharesinol formation and the following conversion of agatharesinol to sequirin C is regulated separately, resulting in independent control of biosynthesis of these two norlignans in C. japonica; sequirin C biosynthesis might be regulated apart from agatharesinol biosynthesis in spite of sequirin C being formed through agatharesinol as a biosynthetic intermediate (Imai et al 2009). This hypothesis of independent control of the biosynthesis is supported by previous studies: and found that agatharesinol accumulated in the sapwood of C. japonica stem logs allowed to stand after cutting the trees down, and Imai et al (2005Imai et al ( , 2006a found that agatharesinol accumulated in sapwood sticks of C. japonica kept under high humidity after preparing the sticks from fresh wood. It is assumed that the biosyntheses of heartwood extractives including norlignan occurs in dying ray parenchyma cells in intermediate wood during the transition from sapwood to heartwood.…”

Section: Discussionsupporting

confidence: 54%

Clonal variation in heartwood norlignans of Cryptomeria japonica: evidence for independent control of agatharesinol and sequirin C biosynthesis

Bito¹,

Nakada²,

Fukatsu³

et al. 2011

Annals of Forest Science

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Section: Discussionsupporting

confidence: 54%

Clonal variation in heartwood norlignans of Cryptomeria japonica: evidence for independent control of agatharesinol and sequirin C biosynthesis

Bito¹,

Nakada²,

Fukatsu³

et al. 2011

Annals of Forest Science

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“…Lignans are diphenolic compounds derived from the combination of two phenylpropanoid C6‐C3 units at the β and β’ carbon atoms and can be linked to additional ether, lactone, or carbon bonds; they have a 1,4‐diarylbutan like chemical structure (Lewis & Davin, ) and are derived from the shikimic acid biosynthetic pathway (Imai, Nomura, & Fukushima, ). Lignans are vascular plant secondary metabolites, with widespread occurrence in the plant kingdom and to which are attributed a wide range of physiological properties, positively influencing human health (Durazzo, ).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

614

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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“…Lignans are 1,4-diarylbutan compounds derived from the shikimic acid biosynthetic pathway (Lewis and Davin, 1999;Imai et al, 2006). In the 1970s, it was still commonly believed that lignans were synthesized in plants only (Hartwell, 1976).…”

Section: Introductionmentioning

confidence: 99%

Lignans: Quantitative Analysis of the Research Literature

et al. 2020

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The current study provides a comprehensive overview and analysis of the lignan literature. Data for the current study were extracted from the electronic Web of Science Core Collection database via the search string TOPIC = ("lignan*") and processed by the VOSviewer software. The search yielded 10,742 publications. The ratio of original articles to reviews was 14.6:1. Over 80% of the analyzed papers have been published since the year 2000 and nearly 50% since the year 2010. Many of the publications were focused on pharmacology, chemistry, and plant sciences. The United States and Asian countries, such as China, Japan, South Korea, and India, were the most productive producers of lignan publications. Among the 5 most productive institutions was the University of Helsinki in Finland, the country that ranked 9 th . Nineteen journals collectively published 3,607 lignan publications and were considered as core journals. Their impact factor did not correlate with the proportion of uncited papers. Highly cited publications usually mentioned phytoestrogen, isoflavone, daidzein, enterodiol, enterolactone, equol, genistein, and isoflavonoid. Cancer (e.g., breast cancer), cardiovascular disease, and antioxidation were the major themes. Clinical trials were estimated to contribute to 0.2-1.1% of the analyzed body of literature, so more of them should be conducted in the future to substantiate the beneficial effects and optimal dose of lignan intake in humans. Moreover, researchers can refer to these findings for future research directions and collaborations.

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Evidence for involvement of the phenylpropanoid pathway in the biosynthesis of the norlignan agatharesinol

Cited by 30 publications

References 9 publications

Clonal variation in heartwood norlignans of Cryptomeria japonica: evidence for independent control of agatharesinol and sequirin C biosynthesis

Clonal variation in heartwood norlignans of Cryptomeria japonica: evidence for independent control of agatharesinol and sequirin C biosynthesis

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Lignans: Quantitative Analysis of the Research Literature

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