Evidence for nonlikage of genes for HLA and hereditary angioedema

Jackson, Charles E.; Sweet, Lawrence C.; Hayashi, Hajime; Paul, Thomas D.

doi:10.1016/0091-6749(78)90055-6

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…In particular, properdin factor B, C2 and C4 genes reside in the region, whilst close linkage has been excluded between HLA and Clr, Cls, C3, C6, C7 and C8 (see Jersild et al 1976). Brief references to lack of linkage between HAE (phenotype not noted) and HLA were reported 2 years ago (Hobart & Lachman 1976, Jackson et al 1976, Jersild et al 1976 we are aware of only two recent studies published with genetic data for the purpose of estimating lod scores (Ohela et al 1977, Robson et al 1978). In the present study, members of fected individuals in three generations have been typed for a large number of genetic marker systems, including several chromosome 6 markers, in a search for close linkage with the locus controlling C1 inh.…”

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Hereditary angioedema: Lack of close linkage with markers on chromosome 6, with data on other markers

et al. 1979

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Members of two Australian families with type A Hereditary Angioedema (HAE), having affected individuals in three generations, were typed for a large number of genetic marker systems in a search for close linkage with the locus controlling C1 inhibitor (Cl inh). The evidence from both families indicated lack of close linkage with HLA or with the loci for Bf and GLO on chromosome 6. Very close linkage was also excluded between the locus for C1 inh and the loci for 6PGD, PGMl and MNSs. The other markers were not informative, but data on all systems showing variation are reported. The publication of similar data for other kindreds will help to determine lod scores for the probability of linkage between the C1 inh locus and loci controlling common protein polymorphisms. Linkage studies of this kind could establish whether the loci controlling type A and B HAE are identical or separate.

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confidence: 99%