Evidence for Prothrombotic Effects of Exercise and Limited Protection by Aspirin

N, Li; Wallén, N H; Hjemdahl, Paul

doi:10.1161/01.cir.100.13.1374

Cited by 134 publications

(109 citation statements)

References 45 publications

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“…3 Platelet P-selectin expression is reported as percentages of P-selectin-positive cells in the platelet population and as absolute counts of P-selectin-positive platelets. Leukocyte CD11b expression is reported as mean fluorescence intensity of the total leukocyte population and of leukocyte subpopulations.…”

Section: Flow Cytometrymentioning

confidence: 99%

mentioning

confidence: 99%

“…2,3,4 Thus, exercise increases circulating activated platelets, platelet-platelet and platelet-leukocyte aggregates, as well as the CD11b expression of circulating leukocytes and leukocyte secretion (elastase) in vivo. 3 Exercise also enhances the responsiveness of platelets and leukocytes to agonist stimulation in vitro. 2,3 Treatment with aspirin 3 or clopidogrel 5 does not prevent exerciseinduced platelet activation, indicating that neither thromboxane A 2 nor ADP is an important mediator.…”

mentioning

confidence: 99%

“…3 Exercise also enhances the responsiveness of platelets and leukocytes to agonist stimulation in vitro. 2,3 Treatment with aspirin 3 or clopidogrel 5 does not prevent exerciseinduced platelet activation, indicating that neither thromboxane A 2 nor ADP is an important mediator. An interesting possibility is that thrombin is involved in the platelet activation induced by strenuous exercise.…”

mentioning

confidence: 99%

“…Exercise also enhances blood coagulation and fibrinolysis, 6 as evidenced by elevated plasma levels of prothrombin fragment 1ϩ2 (F1ϩ2), 3 and tissue plasminogen activator. 7 However, the balance between coagulation and fibrinolysis during exercise has not been well defined.…”

mentioning

confidence: 99%

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Platelet Activity, Coagulation, and Fibrinolysis During Exercise in Healthy Males

Blombäck

et al. 2007

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Background-Relationships between exercise-induced activation of platelets, blood coagulation, and fibrinolysis, and the importance of thrombin for responses to exercise are not clear. Methods and Results-Effects of thrombin inhibition on hemostatic parameters were examined in a double-blind crossover study comparing the direct thrombin inhibitor argatroban (350 g/kg intravenous bolus followed by 25 g/kg per minute of infusion), the indirect thrombin inhibitor enoxaparin (0.75 mg/kg, intravenous bolus), or placebo (saline) in 21 healthy males. Measurements were made at rest, before and during/after thrombin inhibitor treatment, and immediately after exhaustive exercise. At rest argatroban abolished, and enoxaparin attenuated platelet activation by thrombin, but not by adenosine diphosphate. Argatroban and, even more so, enoxaparin decreased thrombin generation (prothrombin F1ϩ2) and the coagulation potential, and increased the fibrinolytic potential. Exercise increased circulating activated platelets (from 5.5Ϯ0.3 to 9.4Ϯ0.9ϫ10 9 /L; PϽ0.001), circulating platelet-platelet microaggregates, the platelet responsiveness to in vitro stimulation, leukocyte activation (leukocyte CD11b expression and plasma elastase), and platelet-leukocyte aggregation (PϽ0.01 for all). Exercise increased coagulation (F1ϩ2; PϽ0.01) and fibrinolysis, but did not alter the balance between them; fibrin gel permeability increased (PϽ0.01), probably because of release of endogenous tissue plasminogen activator from the vessel wall. Neither argatroban nor enoxaparin counteracted exercise-induced platelet or leukocyte activation. Both thrombin inhibitors augmented exercise effects on fibrinolysis. Conclusions-Strenuous exercise enhances platelet and leukocyte activation independently of thrombin. Exercise augments both coagulation and fibrinolysis, but the balance between them appears to be maintained. At therapeutic dosages argatroban counteracted thrombin-induced platelet activation most efficiently, whereas enoxaparin had somewhat stronger anticoagulant and profibrinolytic effects.

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Section: Flow Cytometrymentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Platelet Activity, Coagulation, and Fibrinolysis During Exercise in Healthy Males

Blombäck

et al. 2007

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Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity

Lee¹,

Lip²

2003

Arch Intern Med

215

158

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The pathophysiology of atherothrombosis in cardiovascular disease is complex and multifactorial. No doubt, lifestyle habits such as exercise, smoking, diet, and alcohol consumption may have significant influence on cardiovascular disease. As the hemostatic system is assuming an increasingly prominent role in the pathogenesis and progression of atherovascular diseases, this review evaluates the effects of lifestyle habits (or lifestyle modifications) on blood coagulation, fibrinolysis, and platelet reactivity.

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Effects of warm-up on exercise capacity, platelet activation and platelet–leucocyte aggregation in patients with claudication

Pasupathy

Naseem

Homer‐Vanniasinkam

2005

Journal of British Surgery

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Evidence for Prothrombotic Effects of Exercise and Limited Protection by Aspirin

Cited by 134 publications

References 45 publications

Platelet Activity, Coagulation, and Fibrinolysis During Exercise in Healthy Males

Platelet Activity, Coagulation, and Fibrinolysis During Exercise in Healthy Males

Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity

Effects of warm-up on exercise capacity, platelet activation and platelet–leucocyte aggregation in patients with claudication

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