Evidence for retinoic acid involvement in the regulation of vitellogenesis in the fresh water edible crab,  Oziotelphusa senex senex

Girish, B. P.; Swetha, Ch.; Srilatha, M.; Hemalatha, M.; Reddy, P. Sreenivasula

doi:10.1016/j.cbpa.2018.04.003

Cited by 12 publications

(7 citation statements)

References 39 publications

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“…the upregulation of EcR and RXR mRNA expression levels induces the synthesis of vitellogenin, which enters the blood and is absorbed by the ovary, thereby promoting the synthesis of yolk[39]. Similar results have been found in Metapenaeus ensis studies.…”

supporting

confidence: 84%

“…Previous studies have found the 20-E and EcR - RXR heterodimer complex can promote ovarian development by regulating vitellogenin [ 31 ]. In the study of Oziotelphusa senex senex , the upregulation of EcR and RXR mRNA expression levels induces the synthesis of vitellogenin, which enters the blood and is absorbed by the ovary, thereby promoting the synthesis of yolk [ 39 ]. Similar results have been found in Metapenaeus ensis studies.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study on Growth Index and Nutritional Quality of Female Chinese Mitten Crab Eriocheir sinensis Selected at Different Growth Periods in Rice-Crab Culture Systems

Zhang

Fang

Zhu

et al. 2023

Aquaculture Nutrition

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Research was conducted on the growth performance and nutritional quality of Chinese mitten crabs (Eriocheir sinensis) during a 62-day growing period in a symbiotic coculture comprising rice and crab. Culture experiments were conducted in three rice fields of equal size (996 m2). On days 0 (July 15, D0), 15 (July 30, D15), 31 (August 15, D31), 46 (August 30, D46), and 62 (September 2, D62), tissue samples of 50 female E. sinensis were collected randomly from each rice field. The results showed that the serum growth hormone (GH) content and muscle ecdysone receptor (EcR) mRNA expression levels were higher in the D31 and D46 groups; the content of serum 20-hydroxyecdysone (20-HE) and the mRNA expression levels of retinoid X receptor (RXR), insulin-like growth factor 2 (IGF2), and chitinase (CHI) reached the maximum in the D31 group. Muscle crude protein content gradually increased; hepatopancreas crude protein and crude lipid content began to decrease after reaching the maximum value in the D0 and D15 groups, respectively; the contents of crude protein and crude lipid in the ovary significantly increased in the D46 and D62 groups ( P < 0.05 ). The content of muscle essential amino acids (EAA) reached the maximum in the D46 group; the hepatopancreas EAA content began to decrease significantly in the D31 group ( P < 0.05 ); and the EAA content of the ovary decreased significantly after reaching the maximum value in the D46 group ( P < 0.05 ). The muscle contents of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), polyunsaturated fatty acids (PUFA), and n-3 polyunsaturated fatty acids (n-3PUFA) and the ratio of n-3 polyunsaturated fatty acids/n-6 polyunsaturated fatty acids (n3/n6) decreased significantly in the D31 group ( P < 0.05 ); the hepatopancreas contents of EPA, PUFA, n-3PUFA, and n-6 polyunsaturated fatty acids (n-6PUFA) and the ratio of n3/n6 began to decrease after reaching the maximum value in the D31 group, ethyl behenate (21:0), tetracosanoic acid (24:0), DPA, and DHA contents were detected for the first time in the D31 group; the ovary PUFA, n-3PUFA contents, and n3/n6 ratio of the D46 and D62 groups were significantly lower than those of the D31 group ( P < 0.05 ). During the experimental conditions described here, female E. sinensis raised in rice fields reached rapid growth from August 15 to August 30. Additionally, the nutritional quality of the female E. sinensis edible tissues (muscle, hepatopancreas, and ovary) began to decline after August 15, when sufficient nutrients such as protein, lipid, EAA, and PUFA should be provided to the female E. sinensis.

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supporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Comparative Study on Growth Index and Nutritional Quality of Female Chinese Mitten Crab Eriocheir sinensis Selected at Different Growth Periods in Rice-Crab Culture Systems

Zhang

Fang

Zhu

et al. 2023

Aquaculture Nutrition

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“…High levels of ecdysteroids can induce high levels of EcR expression during the ovarian maturation of crustaceans, thereby initiating the ecdysone signaling pathway to be involved in reproduction ( Okumura et al, 1992 ; Subramoniam, 2000 ). EcR may be involved in vitellogenesis by regulating Vg synthesis ( Girish et al, 2015 ; Gong et al, 2015 ; Girish et al, 2018 ). Su et al (2020) reported that four EsEcR isoforms were detected in the ovaries and hepatopancreas in E. sinensis .…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analysis Reveals the Process of Ovarian Development and Nutrition Metabolism in Chinese Mitten Crab, Eriocheir Sinensis

Feng

Liu²,

Cheng

et al. 2022

Front. Genet.

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Ovarian development is a key physiological process that holds great significance in the reproduction of the Chinese mitten crab (Eriocheir sinensis), which is an economically important crab species for aquaculture. However, there is limited knowledge for the regulatory mechanisms of ovarian development. To study the molecular mechanisms of its ovarian development, transcriptome analysis was performed in the ovary and hepatopancreas of E. sinensis during ovarian stages I (oogonium proliferation), II (endogenous vitellogenesis), and III (exogenous vitellogenesis). The results showed that 5,520 and 226 genes were differentially expressed in the ovary and hepatopancreas, respectively. For KEGG enrichment analysis, the differentially expressed genes in the ovary were significantly clustered in phototransduction-fly, phagosome, and ECM-receptor interaction. Significantly enriched pathways in the hepatopancreas included fatty acid biosynthesis, fatty acid metabolism, and riboflavin metabolism. Further analysis showed that 25 genes and several pathways were mainly involved in oogenesis, including the ubiquitin-proteasome pathway, cyclic AMP-protein kinase A signaling pathway, and mitogen-activated protein kinase signaling pathway. Twenty-five candidate genes involved in vitellogenesis and endocrine regulation were identified, such as vitellogenin, vitellogenin receptor, estrogen sulfotransferase, ecdysone receptor, prostaglandin reductase 1, hematopoietic prostaglandin D synthase and juvenile hormone acid O-methyltransferase. Fifty-six genes related to nutritional metabolism were identified, such as fatty acid synthase, long-chain-fatty-acid-CoA ligase 4, 1-acyl-sn-glycerol-3-phosphate acyltransferase 4, fatty acid-binding protein, and glycerol-3-phosphate acyltransferase 1. These results highlight the genes involved in ovarian development and nutrition deposition, which enhance our understanding of the regulatory pathways and physiological processes of crustacean ovarian development.

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“…However, studies reporting exposure of crustaceans to CIT are limited and to our knowledge, none evaluated the effects of CIT on crustacean reproduction. On the other hand, exogenous exposures to RA in crustaceans were shown to in uence circulating levels of glucose and hormones as well as reproduction and regeneration (Hopkins, 2001;Reddy and Sainath, 2008;Sreenivasula and Srilatha, 2015;Girish et al, 2018;Venkaiah et al, 2019). Thus, the detection and variations of several endogenous isomers of RETs, the expression of RXR, and the responsiveness of crucial physiological processes to RA in crustaceans points towards important functions of RA in their physiology and deserve further research.…”

Section: Introductionmentioning

confidence: 99%

Disruption of oogenesis and molting by methoprene and glyphosate in Gammarus fossarum: involvement of retinoic acid?

Gauthier

Defrance

Jumarie

et al. 2023

Environ Sci Pollut Res

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In the last decade, the freshwater amphipod Gammarus fossarum proved to be a promising sentinel species in active biomonitoring programs to assess the effects of environmental contamination on nontarget organisms. In many vertebrates, xenobiotics cause deregulation of the retinoids (RETs) metabolism implicated in many crucial biological functions. The retinoid system, known in the crustaceans, is yet to be explored in G. fossarum. Therefore, we studied the implication of all-trans retinoic acid (atRA) in the reproduction (embryo, oocyte, and juvenile production) and development (success and delay of moulting) by exposing G. fossarum females to atRA and citral (CIT), a known inhibitor of RA synthesis to simulate an excess or a de ciency of RA, respectively. In parallel, we monitored the effects of methoprene (MET) and glyphosate (GLY), two pesticides suspected to interfere with atRA metabolism and signalling and frequently found in water systems. After 14 days of exposure, atRA, CIT, and MET reduced the number of oocytes, whereas only MET caused a reduced number of embryos. After 44 days, MET and GLY showed a tendency to decrease juvenile production. The duration of the moulting cycle increased following the exposures to atRA and MET, while the treatment with CIT caused a typical endocrine disruptive inverted Ushaped curve. The exposure to GLY led to increased duration of the moulting cycle at the lowest concentrations and lowered moulting success at the highest concentration tested. This study highlights for the rst time the implication of RA in the oogenesis and moulting of G. fossarum and suggests that it may be a potential mediator of MET-induced effects on these processes. This study adds to the comprehension of the reproductive and developmental control in G. fossarum and opens new research avenues to study the effects of xenobiotics on the RET system in this sentinel species. Ultimately, our study will drive the development of RET-based biomarkers for non-target aquatic invertebrates exposed to xenobiotics.

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Evidence for retinoic acid involvement in the regulation of vitellogenesis in the fresh water edible crab, Oziotelphusa senex senex

Cited by 12 publications

References 39 publications

Comparative Study on Growth Index and Nutritional Quality of Female Chinese Mitten Crab Eriocheir sinensis Selected at Different Growth Periods in Rice-Crab Culture Systems

Comparative Study on Growth Index and Nutritional Quality of Female Chinese Mitten Crab Eriocheir sinensis Selected at Different Growth Periods in Rice-Crab Culture Systems

Comparative Transcriptome Analysis Reveals the Process of Ovarian Development and Nutrition Metabolism in Chinese Mitten Crab, Eriocheir Sinensis

Disruption of oogenesis and molting by methoprene and glyphosate in Gammarus fossarum: involvement of retinoic acid?

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