Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case–control and familial samples

Jajodia, Ajay; Kaur, Harpreet; Kumari, Kalpana; Gupta, Meena; Baghel, Ruchi; Srivastava, Ankit; Sood, Mamta; Chadda, Rakesh Kumar; Jain, Sanjeev; Kukreti, Ritushree

doi:10.1016/j.schres.2014.12.031

Cited by 26 publications

(27 citation statements)

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“…Recently, Jajodia et al. (2015) conducted a meta‐analysis comparing their data with data from the Schizophrenia Psychiatric Genome‐Wide Association Study Consortium (PGC‐SCZ) and combined analysis of sporadic case–control association and a transmission disequilibrium test in familial samples from South Indian population. Finally they identified three associations including a functional promoter variant of HTR3A (rs1062613).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment with risperidone increases 5‐HT 3A receptor gene expression in patients with paranoid schizophrenia – data from a prospective study

et al. 2017

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IntroductionThe relationship between peripheral 5‐HT3A receptor mRNA level and risperidone efficiency in paranoid schizophrenia patients is still unknown.MethodsA total 52 first‐episode and drug‐naive paranoid schizophrenia patients who were treated with risperidone and 53 matched healthy controls were enrolled. Patients were naturalistically followed up for 8 weeks. Positive and Negative Syndrome Scale (PANSS) was applied to assess symptom severity of the patients at baseline and at the end of 8th week.ResultsThere was no difference in 5‐HT3A receptor mRNA level between paranoid schizophrenia patients and healthy controls at baseline (p = .24). Among 47 patients who completed 8‐week naturalistic follow‐up, 37 were responders to risperidone treatment. 5‐HT3A receptor mRNA level of paranoid schizophrenia patients did not change in overall patients after 8‐week treatment with risperidone (p = .29). However, 5‐HT3A receptor mRNA level in responders increased significantly (p = .04), but not in nonresponders (p = .81).ConclusionsSuccessful treatment with risperidone increases 5‐HT3A receptor gene expression in patients with paranoid schizophrenia, indicating that 5‐HT3A receptor may be involved in the mechanism of risperidone effect.

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Section: Discussionmentioning

confidence: 99%

Successful treatment with risperidone increases 5‐HT 3A receptor gene expression in patients with paranoid schizophrenia – data from a prospective study

et al. 2017

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“…rs3864075 was found to be strongly associated with schizophrenia in the Indian population [1]. Ganda et al reported the first association study of rs17031835 polymorphism with schizophrenia in the Indonesian population [3].…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have showed several SNPs of GRM7 are associated with the risk of schizophrenia, such as rs17031835 [3], and rs3749380 [26]. A meta-analysis of the population of Indo-European and Dravidian ancestry identified rs3864075 (p=4.06×10 -3 ) strongly associated with schizophrenia [1]. Two SNPs (rs12491620 and rs1450099) in GRM7 showed highly significant association with schizophrenia surviving the FDR correction [10].…”

Section: Discussionmentioning

confidence: 99%

“…Some polymorphisms of metabotropic glutamate receptor 7 (GRM7) have also been found to be associated with schizophrenia [1,3,10,18,19]. Jajodia designed the study to explore the association between GRM7 and schizophrenia through in 840 schizophrenic cases and 876 healthy subjects in the Indian population.…”

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confidence: 99%

“…Jajodia designed the study to explore the association between GRM7 and schizophrenia through in 840 schizophrenic cases and 876 healthy subjects in the Indian population. They found that GRM7 SNPs rs3864075 was strongly associated with schizophrenia [1].…”

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confidence: 99%

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Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population

Niu

Huang

et al. 2015

Neuroscience Letters

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Genetic variability of serotonin pathway associated with schizophrenia onset, progression, and treatment

Hrovatin

Kunej

Dolžan

2019

American J of Med Genetics Pt B

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Schizophrenia (SZ) onset and treatment outcome have important genetic components, however individual genes do not have strong effects on SZ phenotype. Therefore, it is important to use the pathway-based approach and study metabolic and signaling pathways, such as dopaminergic and serotonergic. Serotonin pathway has an important role in brain signaling, nevertheless, its role in SZ is not as thoroughly examined as that of dopamine pathway. In this study, we reviewed serotonin pathway genes and genetic variations associated with SZ, including variations at DNA, RNA, and epigenetic level.We obtained 30 serotonin pathway genes from Kyoto encyclopedia of genes and genomes and used these genes for the literature review. We extracted 20 protein coding serotonin pathway genes with genetic variations associated with SZ onset, development, and treatment from 31 research papers. Genes associated with SZ are present on all levels of serotonin pathway: serotonin synthesis, transport, receptor binding, intracellular signaling, and reuptake; however, regulatory genes are poorly researched. We summarized common challenges of genetic association studies and presented some solutions. The analysis of reported serotonin pathway-SZ associations revealed lack of information about certain serotonin pathway genes potentially associated with SZ. Furthermore, it is becoming clear that interactions among serotonin pathway genes and their regulators may bring further knowledge about their involvement in SZ. K E Y W O R D Sgenetic association studies, genetic variations, pharamcogenetics, schizophrenia, serotonin pathway

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Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case–control and familial samples

Cited by 26 publications

References 60 publications

Successful treatment with risperidone increases 5‐HT 3A receptor gene expression in patients with paranoid schizophrenia – data from a prospective study

Successful treatment with risperidone increases 5‐HT 3A receptor gene expression in patients with paranoid schizophrenia – data from a prospective study

Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population

Genetic variability of serotonin pathway associated with schizophrenia onset, progression, and treatment

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