Evidence for the existence of histamine H1- and H2-receptors on astrocytes of cultured rat central nervous system

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination

“…We analyzed the expression of H1R and H2R during EAE by immunohistochemistry, using two polyclonal antibodies generated in rabbits against the extracellular domain of these receptors (see Materials and Methods). In naive SJL mouse brain, H1R and H2R are expressed, as previously described (41)(42)(43)(44)(45), on rare astrocytes and on epithelial cells of the choroid plexus, whereas H2R was preferentially expressed on the endothelial cells of the blood vessels. In brains obtained from mice with EAE, H1R and H2R are expressed on the surface of mononuclear and other cells in the lesions (Fig.…”

Activation of histamine H1-receptor enhances neurotrophic factor secretion from cultured astrocytes

“…The receptor mechanisms, through which histamine stimulates the NGF secretion from cultured astrocytes, were not precisely defined in these studies. Since cultured astrocytes can express both, histamine H 1 -and H 2 -receptor subtypes on their surface [25][26][27][28][29], we intend in the present work to determine which histamine-receptor subtypes are present in our experimental model of rat neonatal cortical astrocytes. Further one, we established a possible role of histamine H 1 -, H 2 -, H 3 -and H 4 -receptor subtypes in histamine-stimulated NGF secretion from cortical astrocytes in primary culture.…”

Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide

“…Astrocytes share perivascular localization with mast cells [126] are able to maintain the viability of rat serosal mast cells in culture [126] and have receptors for histamine [127]. Astrocyte-derived cytokines/chemokines trigger mast cell degranulation [128].…”