Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse.

Cooper, Robin; Papaconstantinou, John

doi:10.1016/s0021-9258(17)36019-2

Cited by 41 publications

(10 citation statements)

References 25 publications

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“…Each of the introns follows consensus rules for splice junctions and lariat branch point sequences (Breathnach & Chambon, 1981;Padgett et al, 1984). The sequence of the exons agrees exactly with the sequence we reported for the cDNA clone pMAGP4 (Cooper & Papaconstantinou, 1986), with the exception of two differences at positions +1805 and +3237. In the cDNA we observed a T at each position, while in the genomic sequence we find a C at each position.…”

Section: Resultssupporting

confidence: 84%

“…Isolation and Sequencing of Mouse AGP-1 Gene. In a previous publication we provided evidence, based on sequence analysis of cDNA clones, for the existence of at least two AGP genes in the mouse (Cooper & Papaconstantinou, 1986). One of the cDNA clones (pMAGP4) was used to screen a mouse genomic library for AGP sequences.…”

Section: Resultsmentioning

confidence: 99%

“…Mouse AGP Amino Acid Sequences. We have previously published a partial amino acid sequence for mouse AGP deduced from a partial cDNA clone (Cooper & Papaconstantinou, 1986). The sequence of the entire gene has allowed us to complete the amino acid sequence for one of the AGP proteins in the mouse and compare it to rat and human AGP (Figure 7).…”

Section: Resultsmentioning

confidence: 99%

“…Philip Leder), was screened for AGP sequences with a mouse cDNA clone (pMAGP4) previously isolated (Cooper & Papaconstantinou, 1986). Approximately 1.1 X 106 phage were plated onto five large pans, transferred to nitrocellulose, alkali treated, and neutralized, and the DNA was fixed to the filter as described (Benton & Davis, 1977).…”

mentioning

confidence: 99%

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Nucleotide sequence of the mouse .alpha.1-acid glycoprotein gene 1

Cooper¹,

Eckley²,

Papaconstantinou³

1987

Biochemistry

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In a previous paper we presented evidence for the existence of at least two alpha 1-acid glycoprotein (AGP) genes in the mouse. One of the cDNA clones characterized in those studies was used to isolate several unique AGP genomic clones. In these studies we present the complete sequence of one of the mouse AGP genes. The sequence analysis includes 595 base pairs (bp) 5' to the site of initiation of transcription and 135 bp 3' to the polyadenylation signal. This mouse AGP gene, designated AGP-1, has six exons, a structure similar to those of the AGP genes in rats and humans. Analysis of the sequence has revealed a number of potential regulatory sites. These include a run of alternating purine-pyrimidine bases [(GT)N] at +2890 to +2945, flanked by three potential glucocorticoid receptor binding sites within intron 5. Two of these TGTTCT at +3069 to +3074 and +3082 to +3087 flank the (GT)n track at its 3' end, and one, which is oriented in the opposite direction (AGAACA), at +2771 to +2776 flanks the track at its 5' end. A longer version of the glucocorticoid receptor site, GGGTACAATGTGTCCT, has been located in the 5' flanking region of the gene (-94 to -79); the sequence AGAACA is another potential glucocorticoid receptor site oriented in the opposite direction and located at -127 to -122. This entire region, from -146 to -42, in the mouse has a strong homology (approximately 85%) to the 5' flanking region of the rat AGP gene, which contains a 78-bp fragment (-120 to -42) that represents the minimal sequence required for glucocorticoid regulation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Nucleotide sequence of the mouse .alpha.1-acid glycoprotein gene 1

Cooper¹,

Eckley²,

Papaconstantinou³

1987

Biochemistry

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“…1). cDNAs corresponding to two of them, AGP-1 and AGP-2, had been characterized previously (Cooper and Papaconstantinou, 1986; Lee et ai, 1989), and a third gene designated AGP-3 was identified. AGP-1 is contained in X clone Agp-1 while AGP-2 and AGP-3 are in XAgp-25 clones. Only two types of cDNAs and the corresponding proteins of AGP have been identified in the M. domesticus (Baumann, 1984;Lee et ai, 1989).…”

Section: Polymerase Chain Reactionmentioning

confidence: 99%

Structure and Expression of Mouse α₁-Acid Glycoprotein Gene-3 (AGP-3)

Chang

Lai²,

Chen³

et al. 1992

DNA and Cell Biology

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The genome of Mus domesticus has multiple genes of the alpha 1-acid glycoprotein (AGP). Two cDNA clones were identified corresponding to AGP-1 and AGP-2. Moreover, two alleles of AGP-1 exist in inbred mice. The genomic DNA of the AGP-2 gene has been cloned and studied. Here we report the genomic organization of three M. domesticus AGP genes, the sequence analysis of the AGP-3 genomic DNA, and the expression of the AGP-3 gene. The major structural differences between AGP-2 and AGP-3 genes are located in introns 1 and 5. The low level of AGP-3 mRNA can be detected by the polymerase chain reaction (PCR). The molecular basis of the low level expression of AGP-3 and the possible classification of AGP-3 as a pseudogene are discussed.

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The genetic control of sialadenitis versus arthritis in a NOD.Q×B10.Q F2 cross

et al. 2002

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The non‐obese diabetic (NOD) mouse spontaneously develops diabetes and sialadenitis. The sialadenitis is characterized by histopathological changes in salivary glands and functional deficit similar to Sjögren's syndrome. In humans, Sjögren's syndrome could be associated with other connective tissue disorders, such as rheumatoid arthritis. In the present study the genetic control of sialadenitis in mice was compared to that of arthritis. We have previously reported a NOD locus, identified in an F2 cross with the H2q congenic NOD (NOD.Q) and C57BL/10.Q (B10.Q) strains, that promoted susceptibility to collagen‐induced arthritis. The sialadenitis in NOD.Q showed a similar histological phenotype as in NOD, whereas no submandibular gland infiltration wasfound in B10.Q. The development of sialadenitis was independent of immunization with type II collagen and established arthritis. To identify the genetic control of sialadenitis, a gene segregation experiment was performed on an (NOD.Q×B10.Q)F2 cross and genetic mapping of 353 F2 mice revealed one significant locus associated with sialadenitis on chromosome 4, LOD score 4.7. The NOD.Q allele‐mediated susceptibility under a recessive inheritance pattern. The genetic control of sialadenitis seemed to be unique in comparison to diabetes and arthritis, as no loci associated with these diseases have been identified at the same location.

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Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse.

Cited by 41 publications

References 25 publications

Nucleotide sequence of the mouse .alpha.1-acid glycoprotein gene 1

Nucleotide sequence of the mouse .alpha.1-acid glycoprotein gene 1

Structure and Expression of Mouse α₁-Acid Glycoprotein Gene-3 (AGP-3)

The genetic control of sialadenitis versus arthritis in a NOD.Q×B10.Q F2 cross

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Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse.

Cited by 41 publications

References 25 publications

Nucleotide sequence of the mouse .alpha.1-acid glycoprotein gene 1

Nucleotide sequence of the mouse .alpha.1-acid glycoprotein gene 1

Structure and Expression of Mouse α1-Acid Glycoprotein Gene-3 (AGP-3)

The genetic control of sialadenitis versus arthritis in a NOD.Q×B10.Q F2 cross

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Product

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Structure and Expression of Mouse α₁-Acid Glycoprotein Gene-3 (AGP-3)