Evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the antidepressant‐like action of riparin III obtained from <i>Aniba riparia</i> (Nees) Mez (Lauraceae) in mice

Melo, Cristina Carvalho de; Carvalho, Alyne Mara Rodrigues de; Moura, Brinell Arcanjo; Teixeira, Caroline Porto Leite; Vasconcelos, Leonardo Freire; Feitosa, Mariana Lima; Oliveira, Gersilene Valente de; Barbosa-Filho, José Maria; Gutierrez, Stanley Juan Chávez; Fonteles, Marta Maria de França; Vasconcelos, Silvânia Maria Mendes; Sousa, Francisca Cléa Florenço de

doi:10.1111/j.1472-8206.2011.00968.x

Cited by 18 publications

(15 citation statements)

References 46 publications

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“…These findings are in agreement with data from the scientific literature, which support the anxiolytic and antidepressant actions of Riparin III in basic studies (Melo, 2012;Sousa et al, 2004). A previous study, using models of acute depression, verified normalization of depressive behavior and an additional increase in monoamine levels (Melo et al, 2013). The same study concluded that Riparin III was able to increase the levels of monoamines NA, 5-HT, and DA in the striatum and prefrontal cortex, and NA and 5-HT in the hippocampus, while decreasing their metabolites in the striatum and prefrontal cortex (Melo et al, 2013).…”

Section: Discussionsupporting

confidence: 82%

“…A previous study, using models of acute depression, verified normalization of depressive behavior and an additional increase in monoamine levels (Melo et al, 2013). The same study concluded that Riparin III was able to increase the levels of monoamines NA, 5-HT, and DA in the striatum and prefrontal cortex, and NA and 5-HT in the hippocampus, while decreasing their metabolites in the striatum and prefrontal cortex (Melo et al, 2013). Riparin III can probably be used as an anti-depressant and anxiolytic in women during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…The inflammatory response was attenuated by modulation of neutrophil migration (Silva et al, 2015). Riparin II is a molecule with interesting anti-inflammatory activity, possibly due to its ability to decrease TNF-α and IL-1β production and its histamine antagonism (Carvalho et al, 2013). Riparin A, the core structure of all Amazonian riparins, presented weak antioxidant activity, showed moderate activity against colon carcinoma, leishmanicidal activity in promastigotes of L. amazonensis (Araújo et al, 2016), and did not produce a sedative effect, loss of motor coordination or muscle relaxation (Nunes et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Riparin III effect on the development of neural tube embryos of Gallus gallus

Lima¹,

Filho²,

Gutierrez³

et al. 2017

Afr. J. Pharm. Pharmacol.

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The aim of this study is to demonstrate the teratogenicity of Riparin III in embryos of Gallus gallus (domestic) at an early stage of development. This study is unprecedented in the literature. Chicken eggs were used to investigate the morphometry. All the groups were incubated at 37.2 ± 0.1°C and 60 ± 5% relative humidity for 24 h. The embryonic disc was identified and the eggs of the control group were administered 0.1 ml of saline tamponade (PBS, pH 7.0) and those of the other group were administered Riparin III in 25, 50 and 100 μg/ml doses. The eggs were closed with sterile adhesive strips and incubation was continued for another 24 h. All the eggs were then reopened and the embryos dissected from embryonic membranes and evaluated histopathologically with haematoxylin eosin dye for 15 s and washed with distilled water. An embryological development within twelve stages as classified by Hamburger and Hamilton (1951) was obtained. When compared with the control group, the width of the neural tube of the embryos was modified with all Riparin III concentrations. Longer somites resulted from the 50 and 100 μg/ml Riparina III concentrations. The function of the structures was preserved. This drug can potentially be used in pregnant women as an anxiolytic and for treating depression.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Riparin III effect on the development of neural tube embryos of Gallus gallus

Lima¹,

Filho²,

Gutierrez³

et al. 2017

Afr. J. Pharm. Pharmacol.

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“…With the use of specific antagonists, it was observed that Rip III showed antidepressant effects in the forced swimming test. These effects seem to be related to the modulation of the alpha 1 and alpha 2 noradrenergic systems, the serotonergic system, and the D2 dopaminergic system [21,22]. No changes were detected in the open field test [21,22].…”

mentioning

confidence: 91%

Subchronic administration of riparin III induces antidepressive‐like effects and increases BDNF levels in the mouse hippocampus

Vasconcelos

Oliveira

Vidal

et al. 2015

Fundamemntal Clinical Pharma

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Riparin III (Rip III) is an alcamide isolated from Aniba riparia that has presented effects of antidepressant and anxiolytic activities in acute stress behavioral models. The trial's goal was to investigate the activity of Rip III in mice exposed to corticosterone-induced chronic depression model. Swiss female mice, 22-25 g, were distributed in following experimental groups: control group (vehicle1: saline containing 0.1% dimethyl sulfoxide and 0.1% Tween-80, SC+ vehicle 2: distilled water emulsified with 2% Tween-80, PO); stressed group (corticosterone, 20 mg/kg, SC, + vehicle 2, orally); Rip III group (50 mg/kg, orally); and fluvoxamine (Flu) group (50 mg/kg, orally). The mice were exposed to the behavioral tests, and posteriorly, Brain-derived neurotrophic factor protein levels were assessed in hippocampal samples. Statistical analysis of the data was performed by one-way anova, followed by Newman-Keuls test. Both administrations of Rip III and Flu significantly reduced the immobility time in tail suspension and forced swimming tests after 21 days without affecting locomotor function. There was also an increase in BDNF protein levels in the mice hippocampus. These findings further support the hypothesis that Rip III could be a new pharmacological target for the treatment of mood disorders.

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“…In this sense, recent studies conducted by our group provided evidence for the involvement of the serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like action of rip II [6] and rip III [13]. In this sense, recent studies conducted by our group provided evidence for the involvement of the serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like action of rip II [6] and rip III [13].…”

Section: Introductionmentioning

confidence: 67%

Involvement of monoaminergic system in the antidepressant‐like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice

Sousa

Oliveira

Silva

et al. 2012

Fundamemntal Clinical Pharma

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In past studies conducted by our group, riparin I (rip I) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice, while its analogs rip II and III showed anxiolytic and antidepressant-like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (FST) and tail suspension test (TST) as predictive tests for antidepressant activity in rodents. In addition, the involvement of the monoaminergic system in this effect was also assessed. rip I was acutely administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that rip I at both tested doses and administration routes produced a significant decrease in immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α₁ -adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α₂ -adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis) or ritanserin (4 mg/kg, a serotonin 5-HT2(A)/2(C) receptor antagonist) blocked the anti-immobility effects elicited by rip I (50 mg/kg, p.o.) in the FST. Taken together, results indicate that rip I produces significant antidepressant-like activity in the FST and TST, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic and serotonergic systems.

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Evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the antidepressant‐like action of riparin III obtained from Aniba riparia (Nees) Mez (Lauraceae) in mice

Cited by 18 publications

References 46 publications

Riparin III effect on the development of neural tube embryos of Gallus gallus

Riparin III effect on the development of neural tube embryos of Gallus gallus

Subchronic administration of riparin III induces antidepressive‐like effects and increases BDNF levels in the mouse hippocampus

Involvement of monoaminergic system in the antidepressant‐like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice

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