Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium

Cardoso, Chandra Chiappin; Lobato, Kelly R.; Binfaré, Ricardo W.; Ferreira, Priscilla K.; Rosa, Ana Cláudia Ferreira; Santos, Adair R.S.; Rodrigues, Ana Lúcia S.

doi:10.1016/j.pnpbp.2008.11.007

Cited by 78 publications

(44 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In animal studies, Magnesium has been shown to interact with the serotonergic, noradrenergic, and dopaminergic systems [23]. Magnesium also activates tyrosine hydroxylase, the rate-limiting step in dopamine synthesis and it binds serotonin and dopamine to their receptors [24].…”

Section: Methodsmentioning

confidence: 99%

Assessment of Biometal Profile in Children with Autism Spectrum Disorder, with Attention Deficit Hyperactivity Disorder, or with Other Psychiatric Diagnoses: A Comparative Outpatient Study

Pakyürek¹,

Azarang²,

Iosif³

et al. 2018

Acta Psychopathol

View full text Add to dashboard Cite

Background: In recent years, the impact of various micronutrients on the symptoms of ADHD and ASD has been studied. Our study was aimed at evaluating the association between the level of serum magnesium, zinc and ferritin in children diagnosed with ADHD and/or ASD. Methods:This case-control pilot study consisted of 32 children who met DSM-V criteria for ADHD, 15 children who met DSM-V criteria for ASD and 12 age-matched control children from Electronic Medical Record database. Serum magnesium, zinc and ferritin values were com-pared with ANOVA.Results: Blood ferritin level was found to be significantly lower in affected groups (F=5.9, p=0.0056). A trend towards decreased values of plasma zinc level was also found in affected children (F=2.25, p=0.12); whereas no suggestion of any difference in blood magnesium levels between three groups was significant. Non-parametric analyses were also run and the p value for ferritin 0.08, showed weaker evidence of significance. Conclusions:Results of this study indicated that low level of blood ferritin may be a risk factor for development of ASD and ADHD. Future investigations with larger controlled trials are needed and correlational studies would also be helpful.

show abstract

Section: Methodsmentioning

confidence: 99%

Assessment of Biometal Profile in Children with Autism Spectrum Disorder, with Attention Deficit Hyperactivity Disorder, or with Other Psychiatric Diagnoses: A Comparative Outpatient Study

Pakyürek¹,

Azarang²,

Iosif³

et al. 2018

Acta Psychopathol

View full text Add to dashboard Cite

show abstract

“…Drugs were dissolved in saline except for sulpiride which was dissolved in 0.05%v/v dimethylsulfoxide (DMSO) in normal saline. The animals wwere pretreated with ketanserin (5 mg/kg., Binfaré et al, 2009;Cardoso et al, 2009), prazosin (62.5 μg/kg, i.p. ), yohimbine (1 mg/kg, i.p.)…”

Section: Chemicals and Drugs Treatment Regimenmentioning

confidence: 99%

“…To investigate the possible involvement of the noradrenergic system in the antidepressant-like effect produced by phytoecdysteroids in the FST, mice were pretreated with; vehicle (10 ml/kg, i.p. ), prazosin (62.5 μg/kg, i.p., α 1 -adrenoceptor antagonist) (Gu et al, 2012), or yohimbine (1 mg/kg, i.p., α 2 -adrenoceptor antagonist) (Cardoso et al, 2009). Similarly, the role of 5-HT 2A/2C receptor in the antidepressant-like effect elicited by phytoecdysteroids in mice in the FST was also evaluated.…”

Section: Participation Of Monoaminergic Systems In the Antidepressantmentioning

confidence: 99%

Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

Ishola

Ochieng

Olayemi

et al. 2014

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

“…U cilju praćenja antidepresivnog efekta primenjen je test forsiranog plivanja (engl. Forced swim test-FST) (32)(33)(34). Pored toga, primena niže doze magnezijuma od efektivne u kombinaciji sa subterapijskom dozom imipramina, dovela je do ispoljavanja antidepresivnog efekta u FST-u (33).…”

Section: Povezanost Magnezijuma I Depresijeunclassified

Role of magnesium in depression?

Petrović¹,

Pešić²,

Popović³

et al. 2014

Arh farmaciju

View full text Add to dashboard Cite

Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.

show abstract

Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium

Cited by 78 publications

References 65 publications

Assessment of Biometal Profile in Children with Autism Spectrum Disorder, with Attention Deficit Hyperactivity Disorder, or with Other Psychiatric Diagnoses: A Comparative Outpatient Study

Assessment of Biometal Profile in Children with Autism Spectrum Disorder, with Attention Deficit Hyperactivity Disorder, or with Other Psychiatric Diagnoses: A Comparative Outpatient Study

Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

Role of magnesium in depression?

Contact Info

Product

Resources

About