Evidence for the involvement of IL-1β and TNF-α in anti-inflammatory effect and antioxidative stress profile of the standardized dried extract from Miconia albicans Sw. (Triana) Leaves (Melastomataceae)

Lima, Tamires Cardoso; Matos, Saulo Santos; Carvalho, Thaís Feitoza de; Filho, Alex José Silveira; Couto, Luzi P.S.M.; Quintans‐Júnior, Lucindo J.; Quintans, Jullyana S.S.; Silva, Ana Mara O.; Heimfarth, Luana; Passos, Fabíolla Rocha Santos; Gandhi, Sathiyabama Rajiv; Lima, Bruno S.; Silva, Francilene A.

doi:10.1016/j.jep.2020.112908

Cited by 19 publications

(19 citation statements)

References 56 publications

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“…aspera , O. reticulata, and O. virgata were 61.8%, 62.8%, and 60.6%, respectively, at a concentration of 100 μg/mL [ 35 ]. For M. albicans ethanol extract (50%) of leaves, using the same concentration of 3 μg/mL, DPPH inhibition was 36.91% ± 0.93 [ 36 ]. In addition, Memecylon terminale Dalz was also able to scavenge DPPH radicals with an IC 50 value of 43 µg/mL [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

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Seasonal Chemical Evaluation of Miconia chamissois Naudin from Brazilian Savanna

et al. 2022

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Miconia chamissois Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7-O-β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations (p < 0.05) between TPC or TFC content and meteorological data. These results showed that it is possible to obtain extracts from M. chamissois at any time of the year without significant differences in composition.

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Section: Resultsmentioning

confidence: 99%

“…For TBARS, AEMC did not inhibit the formation of reactive species. For the dried extract (50% ethanol v/v) of Miconia albicans leaves, an IC 50 value of 1338.34 μg/mL [ 36 ] was observed. Osbeckia parvifolia Arn.…”

Section: Resultsmentioning

confidence: 99%

Seasonal Chemical Evaluation of Miconia chamissois Naudin from Brazilian Savanna

et al. 2022

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“…The literature presents a study containing the quantification of phenolics and flavonoids in Canela de Velho, indicating total phenolic concentrations of 551,3 ± 3,7 mg g -1 and flavonoid of 367.2 ± 10.5 mg g-1 (LIMA, et al, 2020). However, the sample preparation method by these authors was through ethanolic extraction.…”

Section: Resultsmentioning

confidence: 99%

Bioaccessibility of Metallic Ions and Phenolic Compounds in Teas From Miconia Albicans

Butik¹,

Andrade²,

Quináia³

2022

JER

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The bioaccessibility of Al, Ca, Cr, Cu, Mg, Zn, phenolics and flavonoids during in vitro gastrointestinal digestion of Canela de Velho (Miconia albicans) tea was investigated in 10 samples. Determinations were made by atomic and molecular absorption spectrometry. Metal concentrations in Canela de Velho tea ranged from 343 ± 18 to 1163 ± 36 µg g-1 for Al, 102 ± 23 to 347 ± 13 µg g-1 for Ca, 0.093 ± 0.009 to 0.109 ± 0.003 µg g-1 for Cr, 0.30 ± 0.05 to 0.9 ± 0.2 µg g-1 for Cu, 264 ± 27 to 633 ± 53 µg g-1 for Mg and 1.3 ± 0.3 to 3.1 ± 0.4 µg g-1 for Zn, while the bioaccessibility percentages

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“…The Myconia albicans, populously known as "Old Cinnamon or Canela de Velho", is a species of the Brazilian cerrado and is the most abundant genus of the botanical family melastomatacea, with 4,300 species. The leaves of "Canela de Velho" are widely used in popular medicine, being sold in fairs and stores of natural products and used to treat gastric disorders, rheumatoid arthritis and bacterial infections (Celotto et al, 2003;De Oliveira Viana Arruda et al, 2008;Lima et al, 2020;Vasconcelos et al, 2006). Zebrafish (Danio rario Hamilton 1822) is a teleosteal freshwater fish (2.0 cm long and weighing around 1.5g), and is considered an ideal alternative model for human disease research.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the ethanolic extract of Myconia albicas (Old Cinnamon) in the alternative model of anxiety in zebrafish

Castro

Alexandre

Batista

et al. 2022

RSD

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Myconia albicans is the most abundant genus of the melastomaceous botanical family. In Brazil, it is known as "Canela de Velho", and is used mainly in inflammatory processes. Due to the scarcity of scientific works that report its pharmacological effect, the objective of this study was to perform its chemical characterization, toxicity, and the possible effect on the nervous system, using the experimental model Zebrafish (Dario regio). The organic extract of ethyl acetate (EtOAc) was elaborated through the dry leaves of the cinnamon tree of old. The EtOAc sample was submitted to preliminary phytochemical screening and showed the presence of phenols, flavanoids of the flavones type, flavonols and xanthones, triterpenoids, and alkaloids. Then, flavonoid compounds (369.58±0.074mgEQ/g) and total phenols (81.48±0.005mgEAG/g) were determined. EtOAc was evaluated for its toxicity, with Artemia salina, which showed low toxicity in all the studied doses. In the pharmacological action tests, the doses of 3, 10, or 30 mg/mL were used; 20 µL; oral (v.o.) or intraperitoneal (i.p.). The locomotor activity was evaluated in the open field test, which showed a decrease in the fish. And the anxiolytic activity, in the light & dark preference test, showed that EtOAc at 30 mg/mL, when administered intraperitoneally (IP), has an anxiolytic effect similar to Diazepam IP control. Thus the EtOAC of M. albicans showed the presence of total phenols and several flavonoids, with low toxicity, in which the highest dose presented anxiolytic effect in Zebrafish.

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Evidence for the involvement of IL-1β and TNF-α in anti-inflammatory effect and antioxidative stress profile of the standardized dried extract from Miconia albicans Sw. (Triana) Leaves (Melastomataceae)

Cited by 19 publications

References 56 publications

Seasonal Chemical Evaluation of Miconia chamissois Naudin from Brazilian Savanna

Seasonal Chemical Evaluation of Miconia chamissois Naudin from Brazilian Savanna

Bioaccessibility of Metallic Ions and Phenolic Compounds in Teas From Miconia Albicans

Evaluation of the ethanolic extract of Myconia albicas (Old Cinnamon) in the alternative model of anxiety in zebrafish

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