Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice

Barreto, Rosana S.S.; Quintans, Jullyana S.S.; Amarante, Ruthy K.L.; S., Nascimento. T.; Amarante, Rosana Silva; Barreto, André S.; Pereira, Erik Willyame Menezes; Duarte, Marcelo C.; Coutinho, Henrique Douglas Melo; Menezes, Irwin Rose Alencar de; Zengin, Gökhan; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.jep.2016.06.022

Cited by 67 publications

(42 citation statements)

References 63 publications

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“…α-bisabolol is an oily sesquiterpene alcohol [27,28], which is widely derived from several kinds of plants (e.g. Matricaria recutita, Myrtaceae, Lamiaceae and Apiaceae) [29][30][31][32]. α-bisabolol has multi-functions, such as antimicrobial, anti-inflammatory, anti-nociceptive and even anti-cancer activities [27,28,33].…”

Section: Introductionmentioning

confidence: 99%

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Fang¹,

Wang²,

Li³

et al. 2019

Bioscience Reports

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Endometrial cancer (EC) is one of the most common cancers in females. Although the diagnosis and treatment in early stages can greatly improve the survival rate of patients, the advanced EC still is lethal. Radiotherapy is widely used against EC, and it is a great challenge to find an effective way to overcome the resistance of EC during radiotherapy. α-bisabolol is a promising drug, which has already exhibited its anti-tumor effect in some malignancies. Here we reported that α-bisabolol could inhibit the proliferation of EC cells. It is also shown that their abilities of migration and invasion were effectively reduced by α-bisabolol. Furthermore, our results also demonstrated that α-bisabolol could improve sensitivity of EC cells in radiotherapy and further inhibited the growth of EC cells. By Western blot, we found the expression of matrix metalloproteinases-9 (MMP-9) and cyclin E were significantly decreased, which indicated that EC cells can be further suppressed by using α-bisabolol and radiotherapy. It is also demonstrated in our study that the rate of apoptotic cells is markedly increased in EC by using these two treatments. The significant decrease in X-linked inhibitor of apoptosis protein (XIAP) and increase in caspase-3 detected in our study suggested that the enhancement of apoptosis is mediated by XIAP/caspase-3 pathway, which was further confirmed by examining the downstream effectors of caspase-3, COX-2, PARP and cleaved PARP. In the present study, we demonstrated that α-bisabolol could enhance the sensitivity of EC cells to radiotherapy, which provide a novel alternative for overcoming radioresistance of EC cells and achieving a better outcome in radiotherapy.

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Section: Introductionmentioning

confidence: 99%

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Fang¹,

Wang²,

Li³

et al. 2019

Bioscience Reports

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“…The empirical use of medicinal plants and natural products has passed from generation to generation for thousands of years with a wide range of biological activities produced by the constituents of herbal products have been elucidated (Atanasov et al, ; Cragg & Newman, ). α‐bisabolol, the primary constituent of the essential oil from several plants has diverse biological activities e.g., antimicrobial (Vila et al, ), antitumor (da Silva et al, ), antinociceptive, anti‐inflammatory, and gastroprotective activities (Barreto et al, ; Leite et al, ; Rocha et al, ). In this study, we report systemic antinociceptive and anti‐inflammatory effects induced by α‐bisabolol, diclofenac, and the diclofenac–α‐bisabolol combination.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have demonstrated an antinociceptive effect induced by α‐bisabolol in pain‐related behavioral responses to intraperitoneal cyclophosphamide, capsaicin, formalin, acetic acid, mustard oil, and intracolonic mustard oil (Leite et al, ; Leite, Fernandes, de Menezes, da Costa, & Campos, ). In other studies, α‐bisabolol suppressed the nociceptive behaviors in a dose‐independent manner in the footpad formalin test, paw mechanical inflammatory hypernociception, and orofacial pain tests (Barreto et al, ; Leite et al, ; Rocha et al, ; Tomić et al, ).…”

Section: Introductionmentioning

confidence: 86%

“…α‐bisabolol is the primary constituent of the essential oils from several plants including German chamomile ( Matricaria recutita ), Plinia cerrocampanensis Barrie (Myrtaceae), Stachys lavandulifolia Vahl (Lamiaceae), and Laserpitium zernyi Hayek (Apiaceae) (Barreto et al, ; McKay & Blumberg, ; Popović et al, ; Vila et al, ). There are also reports regarding the antimicrobial, antioxidant, anti‐inflammatory, antinociceptive, anti‐spasmotic and anxiolytic effects of several of these plants (Barreto et al, ; McKay & Blumberg, ; Popović et al, ; Vila et al, ). α‐bisabolol thus has diverse biological activities, such as antimicrobial (Vila et al, ), anti‐tumor (da Silva et al, ), and gastroprotective activity (Rocha et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…However, the highest dose of the diclofenac–MCE combination was associated with gastric injury, suggesting that systemic MCE may be interfering with the gastroprotective factors of chamomile (Al‐Hashem, ; Rocha et al, ). In this context, α‐bisabolol can induce antinociceptive, anti‐inflammatory, and gastroprotective effects in rodents (Barreto et al, ; Bezerra, Leal, Nogueira, & Campos, ; Leite et al, ; Kim et al, ; Rocha et al, ). The aim of this work was to explore the effects from the interaction between α‐bisabolol and diclofenac on rat paw inflammation by carrageenan injection, rat formalin‐induced nociception and on rat gastric integrity.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological interaction of α‐bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats

Ortiz

Cariño-Cortés

Ponce‐Monter

et al. 2017

Drug Development Research

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Preclinical Research & Development The combination of nonsteroidal anti-inflammatory drugs (NSAIDs) with herbal products having analgesic and anti-inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between α-bisabolol and the NSAID, diclofenac on nociception (formalin test), inflammation (paw inflammation produced by carrageenan) and gastric injury in rat was assessed. Diclofenac, α-bisabolol, or diclofenac-α-bisabolol combinations produced antinociceptive and anti-inflammatory effects in rat (p < .05). The systemic administration of diclofenac, but not α-bisabolol, produced gastric damage while the diclofenac-α-bisabolol combinations produced limited gastric damage. Effective dose (ED ) values were determined for each individual drug and analyzed isobolographically. The theoretical ED values for the antinociceptive (98.89 mg/kg) and the anti-inflammatory (41.2 mg/kg) effects differed from the experimental ED values (antinociception: 38.7 mg/kg and anti-inflammation: 13.4 mg/kg). We concluded that the interactions between diclofenac and α-bisabolol are synergistic. These data suggest that the diclofenac-α-bisabolol combinations can interact to produce minor gastric damage, thereby offering a safer therapeutic alternative for the clinical management of inflammation and/or inflammatory pain.

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Methyl jasmonate ameliorates pain‐induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation

Mohammadinia,

Esmaeili‐Mahani,

Abbasnejad

et al. 2024

Brain and Behavior

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ObjectiveOrofacial pain with high prevalence is one of the substantial human health issues. The importance of this matter became more apparent when it was revealed that orofacial pain, directly and indirectly, affects cognition performances. Currently, researchers have focused on investigating pharmaceutics to alleviate pain and ameliorate its subsequent cognitive impairments.DesignIn this study, the rats were first treated with the central administration of methyl jasmonate (MeJA), which is an antioxidant and anti‐inflammatory bio‐compound. After 20 min, orofacial pain was induced in the rats by the injection of capsaicin in their dental pulp. Subsequently, the animals’ pain behaviors were analyzed, and the effects of pain and MeJA treatments on rats learning and memory were evaluated/compared using the Morris water maze (MWM) test. In addition, the expression of tumor necrosis factor‐α (TNF‐α), IL‐1β, BDNF, and COX‐2 genes in the rats’ hippocampus was evaluated using real‐time polymerase chain reaction.ResultsExperiencing orofacial pain resulted in a significant decline in the rats learning and memory. However, the central administration of 20 μg/rat of MeJA effectively mitigated these impairments. In the MWM, the performance of the MeJA‐treated rats showed a two‐ to threefold improvement compared to the nontreated ones. Moreover, in the hippocampus of pain‐induced rats, the expression of pro‐inflammatory factors TNF‐α, IL‐1β, and COX‐2 significantly increased, whereas the BDNF expression decreased. In contrast, MeJA downregulated the pro‐inflammatory factors and upregulated the BDNF by more than 50%.ConclusionsThese findings highlight the notable antinociceptive potential of MeJA and its ability to inhibit pain‐induced learning and memory dysfunction through its anti‐inflammatory effect.

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Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice

Cited by 67 publications

References 63 publications

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Pharmacological interaction of α‐bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats

Methyl jasmonate ameliorates pain‐induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation

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