Evidence for the Photoprotective Effects of Vitamin E

Fryer, Michael J.

doi:10.1111/j.1751-1097.1993.tb09566.x

Cited by 116 publications

(56 citation statements)

References 71 publications

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“…The inhibitory effects of curcumin were attributed to its ability to scavenge ROS. Curcumin can prevent UV irradiation-induced apoptotic changes in human epidermoid carcinoma A431 cells [69].…”

Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

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Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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Skin is the largest body organ that serves as an important environmental interface providing a protective envelope that is crucial for homeostasis. On the other hand, it is a major target for toxic insult by a broad spectrum of physical and chemical agents that are capable of altering its structure and function. There are a large number of dietary contaminants and drugs can manifest their toxicity in skin. These environmental toxicants or their metabolites are inherent oxidants and/or directly or indirectly drive the production of a variety of reactive oxidants also known as reactive oxygen species. These are short-lived entities that are continuously generated at low levels during the course of normal aerobic metabolism. These are believed to activate proliferative and cell survival signaling that can alter apoptotic pathways that may be involved in the pathogenesis of a number of skin disorders. The skin possesses an array of antioxidant defense mechanisms that interact with toxicants to obviate their deleterious effect. The ''antioxidant power'' of a food is an expression of its capability both to defend the human organism from the action of the free radicals and to prevent degenerative disorders. Plants like olive trees have their own built-in protection against the oxidative damage of the sun, and these built-in protectors function as cell protectors in our own body. Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive.

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Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

“…Curcumin possesses anti-inflammatory [51,69], antitumoral, and antioxidant properties. The inhibitory effects of curcumin were attributed to its ability to scavenge ROS.…”

Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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“…by scavenging free radicals and lipid peroxyl radicals, removing oxidatively damaged biomolecules and other types of action [4]. Therefore, apart from using chemical and/or physical sunscreens, supplementation of the skin with antioxidants and thereby strengthening its antioxidant capacity is a further approach in limiting UVR-induced skin damage [5, 6]. Whereas the photoprotective effect of topical antioxidants applied before UVR exposure is being recognized [7, 8, 9, 10, 11, 12], the effect of these compounds administered after irradiation is unclear.…”

Section: Introductionmentioning

confidence: 99%

Effect of Topical Antioxidants on UV-Induced Erythema Formation when Administered after Exposure

et al. 1999

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Background: Photoprotective effects of topically applied antioxidants when applied before ultraviolet radiation (UVR) exposure are well known. Their protective effect when applied after UVR exposure is, however, less established. Objective: In a randomized, double-blinded, placebo-controlled human study the short-term photoprotective effects of different antioxidants and of their combinations were evaluated when applied after UVR exposure. Methods: Melatonin (N-acetyl-5-methoxytryptamine), vitamin E (α-tocopherol) and vitamin C (ascorbic acid) were topically administered alone or in combination following UVR exposure as single applications (immediately or 30 min after irradiation, respectively) or as multiple applications (three times: 30 min, 1 h and 2 h after irradiation). The erythemal reaction was evaluated visually and noninvasively with bioengineering methods (skin color and skin blood flow). Results: No significant protective effect of melatonin or the vitamins when applied alone or in combination were obtained when antioxidants were applied after UVR exposure. No improved photoprotective effect was obtained when multiple applications were done. Conclusion: UVR-induced skin damage is a rapid event, and antioxidants possibly prevent such damage only when present in relevant concentration at the site of action beginning and during oxidative stress.

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“…These particular dietary factors have been hypothesized to play a role in skin cancer development based on the results of animal and in vitro studies and have been the focus of epidemiologic research in humans (7,8,11,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Table 1 summarizes the potential mechanisms by which these dietary factors may act in the development and prevention of skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Role of Dietary Factors in the Development of Basal Cell Cancer and Squamous Cell Cancer of the Skin

McNaughton

Marks

Green

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The role of dietary factors in the development of skin cancer has been investigated for many years; however, the results of epidemiologic studies have not been systematically reviewed. This article reviews human studies of basal cell cancer (BCC) and squamous cell cancer (SCC) and includes all studies identified in the published scientific literature investigating dietary exposure to fats, retinol, carotenoids, vitamin E, vitamin C, and selenium. A total of 26 studies were critically reviewed according to study design and quality of the epidemiologic evidence. Overall, the evidence suggests a positive relationship between fat intake and BCC and SCC, an inconsistent association for retinol, and little relation between B-carotene and BCC or SCC development. There is insufficient evidence on which to make a judgment about an association of other carotenoids with skin cancer. The evidence for associations between vitamin E, vitamin C, and selenium and both BCC and SCC is weak. Many of the existing studies contain limitations, however, and further well-designed and implemented studies are required to clarify the role of diet in skin cancer. Additionally, the role of other dietary factors, such as flavonoids and other polyphenols, which have been implicated in skin cancer development in animal models, needs to be investigated.

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Evidence for the Photoprotective Effects of Vitamin E

Cited by 116 publications

References 71 publications

Oxidative Stress and Skin Cancer: An Overview

Oxidative Stress and Skin Cancer: An Overview

Effect of Topical Antioxidants on UV-Induced Erythema Formation when Administered after Exposure

Role of Dietary Factors in the Development of Basal Cell Cancer and Squamous Cell Cancer of the Skin

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