Evidence for the presence of oxytocin in the corpus luteum of the goat

Homeida, A.M.

doi:10.1111/j.1476-5381.1986.tb14584.x

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…In subsequent years, presence of luteal oxytocin was reported for the cow [4], cynomolgus monkey [5], goat [6], baboon [7] and sow [8]. Although corpora lutea of the sow have been shown to contain oxytocin it is the uterus of this species that produces the majority of oxytocin of reproductive tract origin [9,10].…”

Section: Ovarian Oxytocinmentioning

confidence: 99%

Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum

Stormshak

2003

Reprod Biol Endocrinol

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A review of the current state of knowledge of oxytocin production by the preovulatory follicle and corpus luteum is presented. Corpora lutea of a number of mammalian species have been found to synthesize oxytocin. However, the synthesis and secretion of this nanopeptide by the corpus luteum of the ruminant has been most extensively studied because of the potential role of this peptide in facilitating luteal regression. While much information exists relative to various biochemical and endocrine factors that impact on oxytocin gene expression, this aspect about luteal synthesis of this peptide hormone remains enigmatic. Prostaglandin F-2α (PGF-2α) has been shown to be a primary endogenous hormone responsible for triggering luteal secretion of oxytocin. Details are provided regarding the PGF-2α-induced intracellular signal transduction pathway that ultimately results in exocytosis of luteal oxytocin. Evidence is also presented for potential autocrine/paracrine actions of oxytocin in regulating progesterone production by luteal and granulosa cells. Concluding remarks highlight aspects about luteal oxytocin production that require further research.

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Section: Ovarian Oxytocinmentioning

confidence: 99%

Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum

Stormshak

2003

Reprod Biol Endocrinol

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“…Corpora lutea (CL) were removed under halothane anaesthesia from three animals from each group on day 18 of the cycle. CL extracts were prepared as previously described (Homeida, 1986).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

“…The concentration of progesterone and the PGF2, metabolite, 13,14-dihydro-15-keto prostaglandin F (PGFM) in the plasma were estimated by radioimmunoassay (RIA) as previously described (Cooke & Homeida, 1985;Homeida, 1986). The intra-and inter-assay coefficients of variation were 4.6% (n = 12) and 10.6% (n = 15), respectively for progesterone and 8.0% (n = 9) and 11.2% (n = I1), respectively for PGFM.…”

Section: Hormone Assaysmentioning

confidence: 99%

“…There is evidence now to suggest that the corpus luteum of non-pregnant women, cows, sheep and goats contains oxytocin (Wathes & Swan, 1982;Flint & Sheldrick, 1982;Homeida, 1986). Oxytocin (OT) given exogenously in pharmacological doses interrupted the oestrous cycle of the goat and cow and caused luteolysis (Armstrong & Hansel, 1959;Cooke & Knifton, 1981).…”

Section: Introductionmentioning

confidence: 99%

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Effects of oxytocin‐antagonist injections on luteal regression in the goat

Homeida

Khalafalla

1987

British J Pharmacology

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Intra-arterial administration of 0.25 ml physiological saline to the non-pregnant goat between days 12 and 20 of the oestrous cycle did not affect luteal regression, which was characterized by decreasing peripheral plasma progesterone concentration, beginning on day 13 of the oestrous cycle, and an increase in the plasma concentration of 13, 14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) as oestrus approached on about day 20. Intra-arterial administration of oxytocin antagonist (OA) in saline at a dose of 0.2 microgram kg-1 body weight to goats between days 12 and 20 of the cycle significantly (P less than 0.001) delayed luteal regression beyond day 20 (to day 26). Injection of OA maintained plasma progesterone secretion at 4-5 ng ml-1 till day 23 of the cycle and suppressed the increase in PGFM concentration. Corpus luteum extract (100 microliters) of OA-treated animals released a significant (P less than 0.001) amount of PGF2 alpha from rat uterus in vitro as did authentic oxytocin. This oxytocic material failed to release PGF2 alpha during luteolysis in the goat, suggesting that oxytocin receptors for PGF2 alpha release may be occupied by OA. It is concluded that oxytocin-receptor interaction in the uterus may be the stimulus for PGF2 alpha release which triggers luteal regression in the goat.

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“…Recent investigations have shown that oxytocin is secreted in substantial amounts by the corpus luteum (CL) in several species (Flint & Sheldrick, 1982;Wathes & Swann, 1982;Fields et al, 1983;Kahn-Dawood & Dawood, 1983;Wathes et ai, 1983;Kahn-Dawood et al, 1984;Homeida, 1986a). Oxytocin could be involved in regulating luteal regression either directly by a local action on the corpus luteum as in monkeys (Auletta et al, 1984) or indirectly by inducing the release of prostaglandin F-2a , the uterine luteolysin (Horton & Poyser, 1976) in animals such as goat (Cooke & Knifton, 1981;Cooke & Homeida, 1982 and sheep (Fairclough et ai, 1984).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of luteal function by oxytocin antagonist in goats (Capra hircus)

Homeida

Al-Eknah²

1992

Reproduction

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Summary. Early corpus luteum development in nonpregnant and pregnant goats was characterized by a steady increase in peripheral plasma concentrations of progesterone and a high release of prostacyclin (PGI-2) but low release of prostaglandin F-2\g=a\ (PGF2\g=a\).Jugular administration of oxytocin antagonist (OXA) (0\m=.\2\g=m\g/kg/day) on the day of oestrus and for 3 days thereafter to cyclic and mated goats, significantly (P < 0\m=.\001) inhibited progesterone and prostaglandin secretion and reduced conception rate. Co\ x=req-\ administration of PGI-2 (200 \g=m\g/day) with OXA resulted in a steady increase of progesterone and establishment of pregnancy, but co-administration of (175 \g=m\g/day) with OXA had no effect. It is suggested that oxytocin is required for early development of the corpus luteum and such effects may be mediated via PGI-2 production.

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Evidence for the presence of oxytocin in the corpus luteum of the goat

Cited by 13 publications

References 21 publications

Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum

Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum

Effects of oxytocin‐antagonist injections on luteal regression in the goat

Inhibition of luteal function by oxytocin antagonist in goats (Capra hircus)

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