Evidence for Thyroid Hormone as a Positive Regulator of Serum Thyrotropin Bioactivity

Oliveira, J. H. A.; Barbosa, Erika Ribeiro; Kasamatsu, Teresa S.; Abucham, Júlio

doi:10.1210/jc.2006-2217

Cited by 22 publications

(7 citation statements)

References 21 publications

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“…Thyroid hormone stimulates the synthesis of hCG and the level of serum thyroid hormone is a positive regulator of serum thyrotropin bioactivity. Due to the fact that TSH and hCG share a certain similarity, being members of the same glucoprotein family, it appears possible that serum thyroid hormones can also positively regulate hCG bioactivity, which in turn increases the biological effects on the myometrium until parturition [1, 4, 14, 23]. …”

Section: Discussionmentioning

confidence: 99%

Free Thyroxine Level in the High Normal Reference Range Prescribed for Nonpregnant Women May Reduce the Preterm Delivery Rate in Multiparous

Torremante

Flock

Kirschner

2011

Journal of Thyroid Research

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Preterm birth is the most common reason for perinatal morbidity and mortality in the western world. It has been shown that in euthyreotic pregnant women with thyroid autoimmune antibodies, L-Thyroxine replacement reduces preterm delivery rate in singleton pregnancies. We investigated in a nonrandomized retrospective observational study whether L-Thyroxine replacement, maintaining maternal free thyroxine serum level in the high normal reference range prescribed for nonpregnant women also influences the rate of preterm delivery in women without thyroid autoimmune antibodies. As control group for preterm delivery rate, data from perinatal statistics of the State of Baden-Württemberg from 2006 were used. The preterm delivery rate in the study group was significantly reduced. The subgroup analysis shows no difference in primiparous but a decline in multiparous by approximately 61% with L-Thyroxine replacement. Maintaining free thyroxine serum level in the high normal reference range prescribed for nonpregnant women may reduce the preterm delivery rate.

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Section: Discussionmentioning

confidence: 99%

Free Thyroxine Level in the High Normal Reference Range Prescribed for Nonpregnant Women May Reduce the Preterm Delivery Rate in Multiparous

Torremante

Flock

Kirschner

2011

Journal of Thyroid Research

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“…The sialylation pattern shows circadian changes and is high at night and low during the day (64). Glycosylation is regulated by T 4 and treatment of hypothyroidism with L-T 4 normalized the sialylation pattern (65).…”

Section: European Journal Of Endocrinologymentioning

confidence: 98%

MECHANISMS IN ENDOCRINOLOGY: Impact of isolated TSH levels in and out of normal range on different tissues

Frőhlich

Wahl

2016

European Journal of Endocrinology

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Routine treatment of thyroid cancer (TC) includes long-term suppression of TSH. The necessity of this treatment in low-and intermediate-risk patients as well as the extent of TSH suppression is currently under discussion. A literature search was performed to illustrate the role of TSH in extrathyroidal cells and to identify potential reasons for different effects of exogenously suppressed and endogenously low TSH levels. Although adverse effects of subnormal and supranormal TSH blood levels on heart and brain have not been consistently found, studies show a clear negative effect of suppressed TSH levels on bone mineral density. Experimental data also support an important role of TSH in the immune system. The ability of levothyroxine (L-T 4 ) to regulate TSH levels and triiodothyronine levels in a physiological manner is limited. Reduction of circadian changes in TSH levels, decrease of thyroid hormone-binding proteins, prevention of potential compensatory increases of TSH levels (e.g., in old age), and unresponsiveness of TSH-producing cells to TRH on L-T 4 treatment might cause adverse effects of suppressed TSH levels. In view of the adverse effects of aggressive TSH suppression, achieving the suggested levels of TSH between 0.9 and 1 mU/l in the treatment of low-to-intermediate risk TC patients appears justified.

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“…A tenyésztőedényekből hajlított üvegpipettával "felszedett" sejteket 24 lyukú tenyésztőtárcákba osztottuk (10 5 sejt/lyuk), 48 óra múlva 0,5 ml izobutil-metilxantin hozzáadása után két órán át inkubáltuk 37 °C-on a kontrollegyénekből és a betegből származó savó jelenlétében. Az intracelluláris cAMP meghatározása RPA 509 cAMP kit (Amersham) felhasználásával történt [10][11][12]. Az intraassay 12,7%, az intraassay-koefficiens 21% volt.…”

Section: Laboratóriumi Módszerekunclassified

A makro-TSH diagnosztikus és terápiás jelentősége Hashimoto-thyreoiditises betegekben

Balázs

Rácz

2017

Orvosi Hetilap

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Bevezetés: A makro-TSH szerkezete, incidenciája és klinikai szerepe pajzsmirigybetegekben nem tisztázott. Célkitűzés: A makro-TSH előfordulási gyakoriságának, tulajdonságainak meghatározása Hashimoto-thyreoiditises betegek savójában. Módszer: A Hashimoto-thyreoiditises betegek vérmintáiban a makro-TSH-t meghatározták polietilén-glikol precipitációs módszerrel és protein G agaróz abszorpciós, illetve gélfiltrációs kromatográfiával. A makro-TSH biológiai aktivitását TSH-receptorral transzfektált CHO bioassay módszerével mérték. A betegek L-tiroxin-kezelésben részesül-tek (átlagosan 66,5 µg/nap), a betegek fele pedig szelént is kapott (átlagosan 60 µg/nap). Eredmények: 880 Hashimoto-thyreoiditises beteget (728 nő, átlagéletkor 44,8 év) vontak be a vizsgálatba. A makro-TSH-t 41 betegben (4,6%) mutatták ki, az átlagos TSH-szint a PEG-precipitáció előtt 185,4 ± 35 IU/l volt, a precipitáció után pedig 5,55 ± 1,8 IU/l. Az anti-TPO-szint 445 ± 51 IU/l volt és fokozatosan csökkent 212 ± 51 IU/l-re egyéves tiroxin-és szelénkezelés után. Mind a PEG-precipitációs, mind a protein G abszorpciós módszerrel, illetve gélkromatográfiás eljárással a TSH elleni antitest jelenlétét mutatták ki a makro-TSH-immunkomplexben. A makro-TSH biológialag inaktívnak bizonyult, mivel a CHO-sejteket nem stimulálta. A makro-TSH a szelénnel nem kezelt csoportban 18 ± 3,2 hónapig, a szelénnel kezeltben 12 ± 1,9 hónapig volt kimutatható. Következtetés: A TSH elleni antitestek fő komponensei a makro-TSH-nak és diagnosztikus, illetve terápiás nehézsége-ket okozhatnak. A PEG-precipitációs eljárás alkalmas szűrőmódszer a makro-TSH bizonyítására. A szelén képes nemcsak az anti-TPO-, hanem a makro-TSH-szint csökkentésére egyaránt. Amikor a TSH-szint 40,0 IU/l feletti a hypothyreosis jelei nélkül, gondolnunk kell a makro-TSH jelenlétére. Orv Hetil. 2017; 158(34): 1346-1350. Kulcsszavak: TSH, makro-TSH, Hashimoto-thyreoiditis, anti-TPO, hypothyreosis Diagnostic and therapeutical significance of macro-TSH in patients with Hashimoto's thyroiditisIntroduction: Structure, importance and incidence and clinical role of macro-TSH not clarified in thyroid diseases. Aim: This study was undertaken to determine the incidence and biological role of macro-TSH in patients with Hashimoto's thyroiditis. Method: Blood samples taken from patients with Hashimoto's thyroiditis were screened for the presence of macro-TSH with the polyethylene glycol method and confirmed with protein G agarose absorption test and gel filtration chromatography. Stimulatory capacity of macro-TSH was measured by CHO cells bio-assay. Patients were treated with L-thyroxine (mean 66.5 µg/day) and half of them with selenium (mean 60 µg/day), respectively. Results: 880 patients (728 female, aged 44.8 yr) with Hashimoto's thyroiditis was involved in the study. Macro-TSH was found in the serum of 41 patients (4.6%), the mean TSH 185.4 ± 35 IU/l was before PEG precipitations and after 5.55 ± 1.8 IU/l. Titre of anti-TPO proved to be 445 ± 51 IU/l and gradulally decreased to 212 ± 51 IU/l after one year ther...

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Evidence for Thyroid Hormone as a Positive Regulator of Serum Thyrotropin Bioactivity

Abstract: These data indicate that serum thyroid hormone level is a positive regulator of TSH bioactivity.

Cited by 22 publications

References 21 publications

Free Thyroxine Level in the High Normal Reference Range Prescribed for Nonpregnant Women May Reduce the Preterm Delivery Rate in Multiparous

Free Thyroxine Level in the High Normal Reference Range Prescribed for Nonpregnant Women May Reduce the Preterm Delivery Rate in Multiparous

MECHANISMS IN ENDOCRINOLOGY: Impact of isolated TSH levels in and out of normal range on different tissues

A makro-TSH diagnosztikus és terápiás jelentősége Hashimoto-thyreoiditises betegekben

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