Throughout Southeast Asia, repressive drug laws have resulted in high
rates of imprisonment in people who inject drugs and people living with HIV
(PLH), greatly magnifying the harm associated with HIV, tuberculosis, and
addiction. We review findings from Malaysia's largest prison to describe
the synergistic effects of HIV, tuberculosis, addiction, and incarceration that
contribute to a‘perfect storm’of events challenging public and
personal health and offer insights into innovative strategies to control these
converging epidemics. The majority of PLH who are imprisoned in Malaysia are
opioid dependent. Although promoted by official policy, evidence-based drug
treatment is largely unavailable, contributing to rapid relapse and/or overdose
after release. Similarly, HIV treatment in prisons and compulsory drug treatment
centers is sometimes inadequate or absent. The prevalence of active tuberculosis
is high, particularly in PLH, and over 80% of prisoners and prison
personnel are latently infected. Mandatory HIV testing and subsequent
segregation of HIV-infected prisoners increases the likelihood of tuberculosis
acquisition and progression to active disease, enlarging the reservoir of
infection for other prisoners. We discuss strategies to control these
intersecting epidemics including screening linked to standardized treatment
protocols for all three conditions, and effective transitional programs for
released prisoners. For example, recently introduced evidence-based
interventions in prisons like antiretroviral therapy (ART) to treat HIV,
isoniazid preventive therapy to treat latent tuberculosis infection, and
methadone maintenance to treat opioid dependence, have markedly improved
clinical care and reduced mortality. Since introduction of these interventions
in September 2012, all-cause and HIV-related mortality have decreased by
50.0% and 75.7% respectively. We discuss the further deployment
of these interventions in Malaysian prisons.