Evidence of a Genetic Relationship Between Susceptibility to 3-Methylcholanthrene-Induced Subcutaneous Tumors and Inducibility of Aryl Hydrocarbon Hydroxylase2

Kouri, Richard E.; Ratrie, Harry; Whitmire, Carrie E.

doi:10.1093/jnci/51.1.197

Cited by 88 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many known examples of species and even strain differences in response to carcinogenic stimuli, attributable to different pathways of metabolizing the compound or to a detoxication process in one species and its lack in others (Weisburger and Williams, 1975), with evidence of corresponding variations in enzyme activity (Kuori, Ratrie and Whitmire, 1973 mice, the results confirmed previous morphological evidence that the thymus did not take part in the induction and development of the leukaemias. The suggested explanation is that only bonemarrow-derived lymphocytes participate in this form of leukaemogenesis (HaranGhera and Peled, 1973;Dexter et al, 1974).…”

Section: Discussionsupporting

confidence: 82%

“…In the SJL/J mice, thymectomy possibly had a slight inhibitory effect in both the control and the phorbol-treated mice, the resitlts corresponding well with previous findings by Haran-Ghera et al, (1967). The lack of a real inhibition by thymectomy suggests a mechanism, proposed by Lamon et al (1973), that immune surveillance is a function of non-thymusderived cells, or that it is a function of a highly specialized T-cell subpopulation which remains intact after thymectomy (Gillette and Fox, 1975).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Smooth-muscle-associated contractile protein in renal mesenchymal tumour cells and in transformed cells from DMN-injected rats

Toh¹,

Hard²,

Cauchi³

et al. 1976

Br J Cancer

View full text Add to dashboard Cite

Summary.-Phorbol, the unesterified parent alcohol of the skin promoter TPA, was administered i.p., twice weekly, throughout the lifetime of mice of 7 inbred strains: males and females of AKR/J, C3Heb and BALB/c, and females of SJL/J, DBA/2, SWR and C57BL. A striking difference in strain response was observed, with a pronounced leukaemogenic effect in SWR, a significant shortening of the latent period for spontaneous reticulum cell sarcomas (RCNB) in SJL/J, and no demonstrable effect in the other strains. When mice of 3 of the above-mentioned strains (SWR, SJL/J and AKR/J) were thymectomized prior to the beginning of phorbol treatment, different patterns of response were again observed. Thymectomy did not influence the leukaemia incidence in SWR mice, slightly inhibited RCNB development in SJL/J mice and converted phorbol into a leukaemogenic agent for AKR/J mice.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Smooth-muscle-associated contractile protein in renal mesenchymal tumour cells and in transformed cells from DMN-injected rats

Toh¹,

Hard²,

Cauchi³

et al. 1976

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…AHHinducible mouse strains were more sensitive than the AHH-noninducible mouse strain in terms of tumor induction by PAH. [16][17][18] These findings suggest that the induction of tumors by PAH will be clearly correlated to their metabolic activation by AHH. We have compared AHH-inducible mice (BALB/c and C57BL/6) with AHH-noninducible mice (DBA/2) in terms of the results in the mouse bone marrow micronucleus assay, 2-stage skin carcinogenesis test 19) and single cell gel electrophoresis (SCGE) assay 20,21) using 7,12-dimethylbenz[a]anthracene (DMBA) as a reference carcinogen.…”

Section: The Induction Of a Micronucleus By Carcinogenic Substancesmentioning

confidence: 93%

Short-Term Screening Method for the Prediction of Carcinogenicity of Chemical Substances. Current Status and Problems of an in vivo Rodent Micronucleus Assay.

Sato

Tomita

2001

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

Various short-term screening methods have been developed to detect mutagenic/carcinogenic substances. They have played important roles not only in screening suspected chemicals but in studying the mechanisms of mutagenesis/carcinogenesis, and have provided useful information for assessing the genetic effects of chemicals on humans. The micronucleus assay is an in vivo mammalian methods, which has been widely used for screening the genotoxic potency of chemical substances. By this assay, the genotoxicity of chemicals, including clastogens and spindle poisons, have been evaluated using immature bone marrow erythrocytes in mice. The use of immature erythrocytes in circulating peripheral blood instead of in bone marrow of mice has been developed in recent years and it has been determined that it gives results as relevant as those of bone marrow cells in mice. Using the peripheral blood of mice has made the micronucleus assay method more practical and useful. Recently, rats have been identified as an acceptable species for this assay, and assays using the peripheral blood of rats are often carried out concomitantly with general toxicity or carcinogenic studies. However, it must be noted that the micronucleus assays have some limitations. The activity of substances which are metabolized rapidly in mice or rats, for example, may hardly be detected by the micronucleus assay; metabolic features of the substances may affect the assay results greatly. In this review, the current status of the micronucleus assay is discussed as a short-term screening method in the context of its usefulness and its limitations.

show abstract

“…Strains carrying the dominant Ahb allele for AHH-inducibility are highly susceptible to development of skin tumors as a result of MCA skin painting (3). In contrast, AHH-noninducible mice, homozygous for the recessive Ahd allele, rarely develop skin tumors but respond to MCA skin painting with the development of thymic lymphoma (2).…”

mentioning

confidence: 99%

Genetically dominant resistance in mice to 3-methylcholanthrene-induced lymphoma.

Mayer¹,

Lilly²,

Duran-Reynals³

1980

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Mice of the RF/J strain are highly susceptible to induction of thymic lymphoma by skin painting with 3-methylcholanthrene (MCA), whereas mice of the 129/J and I/LnJ strains are resistant. Resistance was the dominant trait in F1 mice of crosses of RF with each resistant strain. Analysis of the lymphoma incidence in MCA-painted backcross populations indicated segregation of a single dominant gene for resistance in both crosses. None of these strains show inducibility of the aryl hydrocarbon hydroxylase enzyme system, a phenotype attributed to the dominant Ah b gene which is also known to influence susceptibility to MCA-induced lymphoma. The occurrence of the disease in these backcrosses was independent of the hosts' phenotype at either the H-2 or Fv-1 locus, both of which have shown an influence on susceptibility to murine leukemia virus-associated lymphoma in other experimental systems.The Ah locus in mice governs inducibility of the aryl hydrocarbon hydroxylase (AHH) enzyme system (1) in response to treatment with 3-methylcholanthrene (MCA), and it also exerts a major influence on susceptibility to tumorigenesis by skin painting with this hydrocarbon carcinogen (2). Strains carrying the dominant Ahb allele for AHH-inducibility are highly susceptible to development of skin tumors as a result of MCA skin painting (3). In contrast, AHH-noninducible mice, homozygous for the recessive Ahd allele, rarely develop skin tumors but respond to MCA skin painting with the development of thymic lymphoma (2). However, the various AHH-noninducible mouse strains display marked heterogeneity in their susceptibility to MCA-induced lymphomagenesis. Some strains (e.g., RF/J) have a characteristic high incidence of lymphoma after MCA skin painting, whereas others (e.g., 129/J) have low incidences. This observation indicates that genetic factors in addition to Ah govern susceptibility to MCA lymphomagenesis.We now report the results of preliminary studies of the genetic basis of this polymorphism in susceptibility to MCAinduced lymphoma among AHH-noninducible mice. Our findings suggest that a single gene with a dominant allele for lymphoma resistance governs this polymorphism. Furthermore, in the two strain combinations studied, neither H-2b nor Fv-1 b alleles showed a capacity to interfere with the MCA-induced disease, although both have shown significant effects on susceptibility to lymphoma in systems in which it occurs spontaneously or is induced by inoculation with various strains of murine leukemia virus (MuLV). MATERIALS AND METHODSMice. Mice of inbred strains were obtained from The Jackson Laboratory (Bar Harbor, ME). F1 and backcross mice were bred in our colony. By convention, the female parent is placed first in designating F1 and backcross mice. All mice in these studies were of the homozygous Ahd type (AHH-noninducible), and female mice were used exclusively.MCA Treatment. Female mice were treated with MCA beginning at 12-15 weeks of age (4). The flanks and backs of mice were shaved and then painted (marten fur b...

show abstract

Evidence of a Genetic Relationship Between Susceptibility to 3-Methylcholanthrene-Induced Subcutaneous Tumors and Inducibility of Aryl Hydrocarbon Hydroxylase2

Cited by 88 publications

References 0 publications

Smooth-muscle-associated contractile protein in renal mesenchymal tumour cells and in transformed cells from DMN-injected rats

Smooth-muscle-associated contractile protein in renal mesenchymal tumour cells and in transformed cells from DMN-injected rats

Short-Term Screening Method for the Prediction of Carcinogenicity of Chemical Substances. Current Status and Problems of an in vivo Rodent Micronucleus Assay.

Genetically dominant resistance in mice to 3-methylcholanthrene-induced lymphoma.

Contact Info

Product

Resources

About