Evidence of a novel association of unsaturated fatty acids with Gc (Vitamin D-binding protein)

Williams, Merfyn H.; Alstyne, Eldwin L. Van; Galbraith, Robert M.

doi:10.1016/s0006-291x(88)81330-5

Cited by 63 publications

(30 citation statements)

References 26 publications

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“…The proteins also share a common physiological role, since both Gc-globulin and albumin, have the ability to bind unsaturated fatty acids [22]. In spite of this relationship, the same surgical trauma apparently has different effects on the serum concentrations of the proteins, thus resembling the situation after orthotopic liver transplantation [23].…”

Section: Discussionmentioning

confidence: 99%

Gc-globulin is an acute phase reactant and an indicator of muscle injury after spinal surgery

Dahl

Schiødt

Gehrchen

et al. 2001

Inflammation Research

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The initial changes in Gc-globulin can be explained by increased release of actin from injured muscle tissue. Subsequently Gc-globulin displays characteristics of a so-called positive acute phase reactant, supporting previous in vitro studies, and clinical studies after minor surgery. In spite of genetic linkage and structural homology Gc-globulin and albumin are regulated differently after surgical trauma.

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Section: Discussionmentioning

confidence: 99%

Gc-globulin is an acute phase reactant and an indicator of muscle injury after spinal surgery

Dahl

Schiødt

Gehrchen

et al. 2001

Inflammation Research

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“…This protein also forms high-affinity complexes with monomeric G-actin and thus limits its polymerization and even facilitates depoly merization of filamentous F-actin [17][18][19]. Finally, we have recently reported evidence of interaction of Gc with unsaturated fatty acids, raising the possibility of a large circu lating pool of complexed unsaturated fatty acids, including arachidonic acid [20]. The displacement of the latter, for example, by monomeric G-actin, could allow Gc to mod ulate secondary metabolism to prostaglan dins or other eicosanoids such as leukokinins.…”

Section: Discussionmentioning

confidence: 99%

Group-Specific Component in Neonatal Breast Secretion: Relationship to the Cellular Content

Pittard

Geddes²,

Katikaneni³

et al. 1990

Neonatology

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Group-specific component (Gc) and total albumin concentrations in the breast secretions from 20 full-term infants were measured. The Gc concentrations as well as the albumin concentrations correlated significantly (p < 0.02) with the total cell count and the absolute concentration of each white blood cell type in the breast fluid. The ratio of albumin in neonatal breast secretion to that in neonatal serum was similar to the comparable ratio for Gc. Since albumin and Gc are of similar molecular size, these observations suggest leakage of these two proteins from serum to breast secretion and a possible chemotactic relationship between these proteins and the mononuclear cells in neonatal milk.

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“…5.1). Despite the sequence similarity, the only function DBP shares with the other family members is its fatty-acid-binding ability [40,41].…”

Section: Protein Structurementioning

confidence: 99%

The Vitamin D Binding Protein DBP

Bouillon

2011

Vitamin D

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Evidence of a novel association of unsaturated fatty acids with Gc (Vitamin D-binding protein)

Cited by 63 publications

References 26 publications

Gc-globulin is an acute phase reactant and an indicator of muscle injury after spinal surgery

Gc-globulin is an acute phase reactant and an indicator of muscle injury after spinal surgery

Group-Specific Component in Neonatal Breast Secretion: Relationship to the Cellular Content

The Vitamin D Binding Protein DBP

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