Evidence of Active Invasion of Denervated Areas by Sensory Fibers from Neighboring Nerves in Man

Livingston, W. K.

doi:10.3171/jns.1947.4.2.0140

Cited by 47 publications

(7 citation statements)

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“…The dorsal root ganglion consists of two populations of cells, the ventrolateral and dorsomedial (Levi-Montalcini and Angeletti, 1968). In the periphery, denervation of cutaneous innervation results in collateral sprouting of adjacent nerve fibres (Livingstone, 1947), and a role for NGF in this sprouting has been suggested since administration of antiserum to NGF completely prevents this sprouting (Diamond et al, 1987). Sensory neurons innervate two distinct target regions and depend for their survival and differentiation on trophic support both from the periphery and from the central nervous system (Yip and Johnson, 1984;Kalcheim and Le Douarin, 1986).…”

Section: Discussionmentioning

confidence: 99%

Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion

Ernfors

Persson

1991

Eur J of Neuroscience

138

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Northern blot analysis was used to demonstrate high levels of hippocampus-derived neurotrophic factor/neurotrophin-3 (HDNF/NT-3) mRNA in the embryonic day (E) 13 - 14 and 15 - 16 spinal cord. The level decreased at E18 - 19 and remained the same until postnatal day (P) 1, after which it decreased further to a level below the detection limit in the adult. In situ hybridization revealed that the NT-3 mRNA detected in the developing spinal cord was derived from motoneurons and the decrease seen at E18 - 19 was caused by a reduction in the number of motoneurons expressing NT-3 mRNA. The distribution of NT-3 mRNA-expressing cells in the E15 spinal cord was very similar to the distribution of cells expressing choline acetyltransferase or nerve growth factor receptor (NGFR) mRNA. Moreover, a striking similarity between the developmentally regulated expression of NT-3 and NGFR mRNA was noted in spinal cord motoneurons. A subpopulation of all neurons in the dorsal root ganglia expressed brain-derived neurotrophic factor (BDNF) mRNA from E13, the earliest time examined, to adulthood. These results are consistent with a trophic role of NT-3 for proprioceptive sensory neurons innervating the ventral horn, and imply a local action of BDNF for developing sensory neurons within the dorsal root ganglia.

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Section: Discussionmentioning

confidence: 99%

Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion

Ernfors

Persson

1991

Eur J of Neuroscience

138

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“…The recruitment of a larger number of primary afferents may be the result of an expansion of peripheral receptive fields due to postinjury afferent sprouting (Weddell et al, 1941;Livingston, 1947;Devor et al, 1979): evoked fos-LI Evoked fos-LI.…”

Section: Changes In Fos-li After Ion-ccimentioning

confidence: 99%

Fos expression in the medullary dorsal horn of the rat after chronic constriction injury to the infraorbital nerve

Vos

Strassman

1995

J of Comparative Neurology

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Chronic constriction injury to the rat's infraorbital nerve (IoN-CCI) induces asymmetric face grooming directed to the injured nerve territory and, beginning at 7-12 days postoperative, hyperresponsiveness to mechanical stimulation in this territory (B.P. Vos, A.M. Strassman, and R.J. Maciewicz, 1994, J. Neurosci. 14:2708-2723). To examine central mechanisms involved in these behavioral alterations, changes in nonevoked and mechanical stimulation-evoked fos-like immunoreactivity (fos-LI) following IoN-CCI were quantified in the medullary dorsal horn. Following the appearance of hyperresponsiveness in IoN-CCI rats, experimental and matched sham-operated rats were anesthetized with urethane and received either no stimulation or repeated stimulation with either a 2- or 15-g von Frey hair applied to the hairy skin between vibrissae B3-4/C3-4 on the operated side. Unstimulated IoN-CCI rats had increased fos-LI in laminae I-IV of the ipsilateral medullary dorsal horn. In both groups, mechanical stimulation produced a distinct pattern of fos-LI in the ipsilateral medullary dorsal horn, the quantity of which was related to stimulus intensity. For both stimulus intensities, the total amount and the rostrocaudal spread of evoked fos-LI were significantly larger in IoN-CCI rats. In IoN-CCI rats, stimulation-evoked increases in fos-LI were proportionally larger in laminae I-II than in III-IV. This laminar effect was also present in sham-operated rats but only for 15-g stimulation. Neither condition nor stimulus intensity affected fos-LI in the contralateral medullary dorsal horn. Positive correlations were found between the behavioral parameters of increased trigeminal nociceptive activity and the total amount of fos-LI in the ipsilateral medullary dorsal horn. The results demonstrate that IoN-CCI induces significant alterations in the central processing of afferent signals, which may underlie behavioral manifestations of increased nociceptive activity.

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“…This process represents collateral sprouting or reinnervation, and is a well established mechanism by which partial restoration of sensory functions can occur in situations where injured peripheral nerve axons are unable to regrow to their previous peripheral target (Doucette and Diamond, 1987;Hoffert et al, 1984;Inbal et al, 1987;Diamond, 1981, 1984;Kinnman and Aldskogius, 1986; showing dermal neurofilament protein-immunoreactive fibers. Kinnman et al, 1992;Leonard, 1973;Livingston, 1947;Nixon et al, 1984;Pomeranz et al, 1984;Robinson, 1981;Weddell, 1941;Wiesenfeld-Hallin et al, 1989). The exploration of this process in the peripheral sensory system is therefore of great importance in order to understand how sensory recovery may be promoted in cases with permanently injured nerves.…”

Section: Collateral Sprouting By Sensory Axons In the Skinmentioning

confidence: 99%

Degeneration and regeneration of cutaneous sensory nerve formations

Dubový¹,

Aldskogius

1996

Microsc. Res. Tech.

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Evidence of Active Invasion of Denervated Areas by Sensory Fibers from Neighboring Nerves in Man

Cited by 47 publications

References 1 publication

Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion

Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion

Fos expression in the medullary dorsal horn of the rat after chronic constriction injury to the infraorbital nerve

Degeneration and regeneration of cutaneous sensory nerve formations

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