Evidence of antiplatelet aggregation effects from the consumption of tomato products, according to EFSA health claim requirements

Cámara, Montaña; Fernández‐Ruiz, Virginia; Sánchez-Mata, María Cortes; Díaz, Luis Alfredo Baratas; Kardinaal, A.F.M.; Lieshout, M. van

doi:10.1080/10408398.2019.1577215

Cited by 24 publications

(12 citation statements)

References 48 publications

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“…The bioactive compounds in tomato not only reduce the risk but also prevent or ameliorate CVDs [138] (Figure 2). The antiplatelet aggregation effects of tomato and tomato products support the prevention of CVD disorders [139]. For example, lycopene can improve endothelial function among patients who suffer from CVD [140].…”

Section: Tomato In Cvdsmentioning

confidence: 99%

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Ali

Sina

Khandker

et al. 2020

Foods

278

119

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Tomatoes are consumed worldwide as fresh vegetables because of their high contents of essential nutrients and antioxidant-rich phytochemicals. Tomatoes contain minerals, vitamins, proteins, essential amino acids (leucine, threonine, valine, histidine, lysine, arginine), monounsaturated fatty acids (linoleic and linolenic acids), carotenoids (lycopene and β-carotenoids) and phytosterols (β-sitosterol, campesterol and stigmasterol). Lycopene is the main dietary carotenoid in tomato and tomato-based food products and lycopene consumption by humans has been reported to protect against cancer, cardiovascular diseases, cognitive function and osteoporosis. Among the phenolic compounds present in tomato, quercetin, kaempferol, naringenin, caffeic acid and lutein are the most common. Many of these compounds have antioxidant activities and are effective in protecting the human body against various oxidative stress-related diseases. Dietary tomatoes increase the body’s level of antioxidants, trapping reactive oxygen species and reducing oxidative damage to important biomolecules such as membrane lipids, enzymatic proteins and DNA, thereby ameliorating oxidative stress. We reviewed the nutritional and phytochemical compositions of tomatoes. In addition, the impacts of the constituents on human health, particularly in ameliorating some degenerative diseases, are also discussed.

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Section: Tomato In Cvdsmentioning

confidence: 99%

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Ali

Sina

Khandker

et al. 2020

Foods

278

119

View full text Add to dashboard Cite

show abstract

“…In order to demonstrate the beneficial effects of tomato product on lipid oxidative damage (lipid peroxidation), EFSA requires in vivo studies performance. In addition, the measurement of the following markers is required: changes in F2-isoprostanes in 24-h urine samples; measurement of oxidized LDL particles in the blood using immunological methods (antibodies) with appropriate specificity and the quantification of phosphatidylcholine hydroperoxides (PCOOH), measured in the blood or tissue by High-Performance Liquid Chromatography (HPLC) ( 1 , 5 ).…”

Section: Efsa Tomato and Lycopene Health Claims Requirements And Statusmentioning

confidence: 99%

“…The World Health Organization (WHO) defines cardiovascular disease (CVD) as disorders of the heart and blood vessels originated from a chronic inflammatory vascular process that affects the wall of medium-sized arteries and ends up producing endothelial dysfunction and atherosclerosis. An important intermediate consequence of CVD is endothelial dysfunction, an alteration characterized by the functional loss of the vascular system that precedes the morphological changes characteristic of atherogenesis ( 1 ). Longer-term clinical trials examining clinical cardiology outcomes often define major cardiovascular events to include non-fatal myocardial infarction, non-fatal stroke, and CVD death.…”

Section: Introductionmentioning

confidence: 99%

“…In this situation, the endogenous defense system is overcome by the formation of reactive oxygen species (ROS) that interact with different biomolecules (carbohydrates, lipids, proteins, amino acids, and nucleic acids) and cause cellular damage. Platelets also play a relevant role in these conditions, since it has been shown that platelet hyperaggregability is associated with an increased risk of coronary heart disease ( 1 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

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Scientific Evidence of the Beneficial Effects of Tomato Products on Cardiovascular Disease and Platelet Aggregation

et al. 2022

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Cardiovascular disease (CVD) includes a group of disorders of the heart and blood vessels that includes numerous problems, many of which are related to the process called atherosclerosis. The present work is aimed to analyze the most relevant studies examining the potentially beneficial effects of tomato products on both CVD prevention and antiplatelet aggregation as well as an European Food Safety Authority health claims evaluation on tomato and tomato products. To date, only one health claim has been approved for a concentrated extract of tomato soluble in water (WSTC) marketed under the patented name of Fruitflow® with two forms of presentation: WSTC I and II, with the following claim “helping to maintain normal platelet aggregation, which contributes to healthy blood flow.” Other studies also demonstrate similar beneficial effects for fresh tomatoes, tomato products and tomato pomace extracts.

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“…During the green stage GABA constitutes up to 50% of the free amino acids in tomatoes [145]. In addition, consumption of tomato products attenuates postprandial oxidative stress induced by lipemia and associated inflammatory response [147].…”

Section: Amines and Amino Acidsmentioning

confidence: 99%

Effects of Nutrients on Platelet Function: A Modifiable Link between Metabolic Syndrome and Neurodegeneration?

Arnoldussen

Witkamp

2021

Biomolecules

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Metabolic syndrome increases the risk of vascular dementia and other neurodegenerative disorders. Recent studies underline that platelets play an important role in linking peripheral with central metabolic and inflammatory mechanisms. In this narrative review, we address the activation of platelets in metabolic syndrome, their effects on neuronal processes and the role of the mediators (e.g., serotonin, platelet-derived growth factor). Emerging evidence shows that nutritional compounds and their metabolites modulate these interactions—specifically, long chain fatty acids, endocannabinoids and phenolic compounds. We reviewed the role of activated platelets in neurovascular processes and nutritional compounds in platelet activation.

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Evidence of antiplatelet aggregation effects from the consumption of tomato products, according to EFSA health claim requirements

Cited by 24 publications

References 48 publications

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Scientific Evidence of the Beneficial Effects of Tomato Products on Cardiovascular Disease and Platelet Aggregation

Effects of Nutrients on Platelet Function: A Modifiable Link between Metabolic Syndrome and Neurodegeneration?

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