Evidence of bovine immunodeficiency virus (BIV) infection: Serological survey in Argentina

González, Ester Teresa; Licursi, Maria; Roza, V. Vila; Bonzo, Estela; Mórtola, Eduardo; Frossard, Jean-Pierre; Venables, C.

doi:10.1016/j.rvsc.2007.10.008

Cited by 12 publications

(13 citation statements)

References 27 publications

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“…Our study showed BIV infection is more common than BLV infection in the Iranian cattle we studied and we found no evidence that infection with one virus predisposed to infection with the other. This is consistent with the results reported by [19] although González et al and Meas et al (2002) showed there was a statistical correlation between BIV and BLV infections [15,30]. The reasons for these different results have not been examined but may reflect genetic differences between the cattle and the virus types involved in the studies.…”

Section: Discussionsupporting

confidence: 91%

Bovine immunodeficiency virus and bovine leukemia virus and their mixed infection in Iranian Holstein cattle

Brujeni

Poorbazargani

Nadin-Davis

et al. 2010

J Infect Dev Ctries

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Introduction: Bovine immunodeficiency virus (BIV) and bovine leukemia virus (BLV) have worldwide distributions, but their prevalences in Iran are unknown. We investigated the presence of infections in Iranian Holstein cattle and determined changes in hematological values for infected animals. Methodology: Nested PCR was used on blood samples from 143 animals Holstein cattle to detect proviral BIV and BLV gag sequences. Flow cytometric analysis was performed using monoclonal antibodies (mAbs) against CD4, CD8, and CD21 bovine T lymphocyte subsets. Results: Proviral BIV and BLV gag sequences were detected in 20.3% and 17% of the animals, respectively. BIV-BLV confection was also detected in 4.2% of the study population but this was not statistically significant. Flow cytometric analysis showed that both BIV-infected cows and non-infected ones had CD4/CD8 ratios of 2.45 and 1.43, respectively, and this difference was significant. BLV infected and non-infected animals had no significant differences in their CD4/CD8 ratio. In comparison to non-infected cattle, those with both BIV and BLV had a significant decrease in their CD4/CD8 ratios (1.5 % vs. 2.3; P = 0.01). Conclusion: This is the first report of BIV and BLV infections in Iran. We found no evidence that infection with one agent predisposed an animal to infection with the other. BIV infection may have a role in decreasing T CD8 counts, but this may depend on the genetics of the cattle and virus strains involved.

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Section: Discussionsupporting

confidence: 91%

Bovine immunodeficiency virus and bovine leukemia virus and their mixed infection in Iranian Holstein cattle

Brujeni

Poorbazargani

Nadin-Davis

et al. 2010

J Infect Dev Ctries

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“…JDV was subsequently identified as the causative agent of severe disorders in Bali cattle in 1993 [87]. Serosurveillance studies reported that BIV infection appears worldwide in cattle [88–94], while JDV infection is endemic in Bali cattle, banteng, and cattle of the islands of Southeast Asia including Indonesia and Malaysia [86, 87, 95, 96]. …”

Section: A3 Antagonism By Lentiviral Vif Proteinsmentioning

confidence: 99%

A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

et al. 2017

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Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication. To antagonize APOBEC3-mediated antiviral action, lentiviruses have acquired viral infectivity factor (Vif) as an accessory gene. Mammalian APOBEC3 proteins inhibit lentiviral replication by enzymatically inserting G-to-A hypermutations in the viral genome, whereas lentiviral Vif proteins degrade host APOBEC3 via the ubiquitin/proteasome-dependent pathway. Recent investigations provide evidence that lentiviral vif genes evolved to combat mammalian APOBEC3 proteins. In corollary, mammalian APOBEC3 genes are under Darwinian selective pressure to escape from antagonism by Vif. Based on these observations, it is widely accepted that lentiviral Vif and mammalian APOBEC3 have co-evolved and this concept is called an “evolutionary arms race.” This review provides a comprehensive summary of current knowledge with respect to the evolutionary dynamics occurring at this pivotal host-virus interface.

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“…The detection of BLV infection in cattle is carried out by virological methods-syncytial test (Ferrer et al, 1981;Otachel-Hawranek, 1993;Takahashi et al, 2004;Mingala et al, 2009), serological tests (Kozaczynska, 1999) and by molecular biology methods based on PCR (Naif et al, 1992;Klintevall et al, 1994;Marsolais et al, 1994;Czarnik et al, 2002;González et al, 2008). The implementation of a PCR method in BLV diagnosis could increase the detection number of infected animals.…”

Section: Discussionmentioning

confidence: 99%

Using PCR for early diagnosis of bovine leukemia virus infection in some native cattle

Mohammadabadi¹,

Soflaei²,

Mostafavi³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Bovine leukemia virus (BLV), the causative agent of enzootic bovine leukosis, is an exogenous, B lymphotropic retrovirus belonging to the Retroviridae family that induces persistent lymphocytosis in cattle and sheep. PCR has proven to be particularly suitable for investigating herds of cattle with a very low incidence of BLV infection and for clarifying doubtful serological results obtained by immunodiffusion or ELISA. The native Iranian and Russian cattle have a series of valuable traits that discriminate them as unique breeds that are well able to compete with western analogues. However, their gene pools have not been analyzed with molecular markers, including detection of BLV by PCR. Two pairs of primers were used: gag1 and gag2, and pol1 and pol2, which encompass 347-and 599-bp fragments of the BLV gene, respectively. Sixty-five Iranian Sistani, 120 Yaroslavl, 50 Mongolian, and 35 Black Pied cows were investigated. Among these 270 animals, we obtained 42 positive and 15 doubtful results in the first PCR. The second PCR was very effective in increasing BLV test reliability data to support detection of BLV.

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Evidence of bovine immunodeficiency virus (BIV) infection: Serological survey in Argentina

Cited by 12 publications

References 27 publications

Bovine immunodeficiency virus and bovine leukemia virus and their mixed infection in Iranian Holstein cattle

Bovine immunodeficiency virus and bovine leukemia virus and their mixed infection in Iranian Holstein cattle

A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

Using PCR for early diagnosis of bovine leukemia virus infection in some native cattle

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