Evidence of Defective Growth Hormone Response and Adaptive Hormonal Changes in Fibromyalgia*

Alp, Alev; Oral, Arzu Yilmaztepe; Ocakoğlu, Gökhan; Dirican, Melahat; Yurtkuran, Mustafa

doi:10.1055/s-0034-1374614

Cited by 2 publications

(5 citation statements)

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“…These authors detected a significant reduction in baseline cortisol in all female patients with FM compared to healthy control subjects and described a participating role of HPA in functional somatic disorders including fibromyalgia [ 53 ]. Low baseline cortisol levels in FM patients were also reported in the articles reviewed here [ 18 , 30 , 36 , 40 ].…”

Section: Discussionsupporting

confidence: 70%

“…Of the 10 studies reviewed, four were non-randomized controlled [ 30 , 33 , 35 , 36 ], two randomized controlled [ 18 , 34 ], two observational [ 31 , 32 ], one case-control [ 38 ] and one pilot study [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…This may be mainly attributed to incomplete descriptions of the exercise programs tested and poor patient adherence [ 47 ]. Physical therapy was the second most common intervention tested [ 30 , 36 ] and one study was based on lifestyle interventions [ 34 ]. Three of the studies involved an observational assessment [ 31 , 35 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Variation in pain was described in the study by Geiss et al, who used the pressure pain threshold method [ 33 ], while Pernambuco et al, Riva et al, and Stehlik et al, measured pain more subjectively though the fibromyalgia impact questionnaire (FIQ) and visual analogue scale (VAS), respectively [ 34 , 35 , 38 ]. While this variability suggests these data should be analyzed with caution, they seem to indicate that a guided combined physical therapy/aerobic exercise program involving sessions two days a week over 5 weeks could help relieve pain and reduce plasma cortisol levels [ 18 , 30 ]. Long-term experimental studies based on multifaceted programs could help standardize interventions and detect larger more consistent pain alleviating effects of exercise.…”

Section: Discussionmentioning

confidence: 99%

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Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis

et al. 2020

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This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia.

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Section: Discussionsupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis

et al. 2020

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“…In addition to the structural and functional abnormalities in the central nervous system (CNS), we have to add the hypothesis on the hypothalamic-pituitary-adrenal axis dysfunction, the "stress axis", and most likely the involvement of the sympathetic nervous system and the autonomic nervous system. The growth hormone axis would also be abnormally configured in fibromyalgia patients 15,16 . According to M.B.…”

Section: Complex Etiology Of Fibromyalgiamentioning

confidence: 99%

Significant new quantitative EGG patterns in fibromyalgia

2015

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Background and Objectives: We analyzed the EEG recordings of a sample of fibromyalgia patients, with the goal of looking for new, more objective indicators on the diagnosis and severity assessment of this pathology, and looking also to establish the relationship of these new indicators with different psychological and neuropsychiatric tests. Methods: We compared the EEG recordings of a group of 13 fibromyalgia patients with a normalized database built into the software of the equipment used (Neuronic), and also with a control group of 13 individuals; both groups were selected under the same criteria of inclusion-exclusion. Patients and controls underwent quantitative EEG (eyes closed), according to international 10-20 EEG system and were specifically evaluated throughout various neuropsychiatric and psychological questionnaires. Results: We obtained the absolute powers of QEEG (quantitative) for the different electrode sites and frequency bands, we determined the corresponding values of the deviation from normal (Z-scores), and estimated various indicators and ratios, as well as correlations with the results of psychological tests. Interestingly, the ratios of theta and beta frequencies in relation with alpha appear as one of the most relevant indicators of the severity of the pathology; significant differences were also found in the peak frequency (maximum power per Hz) of the alpha band, and in the frequency peak of the total spectrum. Conclusions: The consistency of the abnormal EEG patterns of fibromyalgia patients revealed the presence of systemic dysfunction at the central nervous system level, beyond possible peripheral anomalies and specific tissue pathologies. Among the indicators and benchmarks achieved, the most important changes concern the frequencies theta, alpha and beta, and still more significant were the values of their ratios in the comparison between patients and controls. The relative values of peak frequencies are also of interest. The promising results achieved suggest that it is necessary to continue the investigation to validate these new diagnostic indicators.

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Evidence of Defective Growth Hormone Response and Adaptive Hormonal Changes in Fibromyalgia*

Cited by 2 publications

References 0 publications

Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis

Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis

Significant new quantitative EGG patterns in fibromyalgia

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