Evidence of hypothalamic-pituitary thyroid abnormalities in children with end-stage renal disease

Pasqualini, Titania; Zantielfer, Debora; Balzaretti, Marta; Granillo, E; Day, Patricia; Ramirez, José A.; Ruiz, Susana; Gutman, R.; Ferraris, Jorge R.

doi:10.1016/s0022-3476(05)82197-3

Cited by 21 publications

(12 citation statements)

References 25 publications

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“…Transient or permanent alteration of the TSH surge has been described in hypercortisolemia (26), critical illness (27-30), postoperative recovery (31), hyperglycemia (32), chronic renal failure (33,34), depression (35-38), and aging (39). None of these was present in the children studied in this project.…”

Section: Discussionmentioning

confidence: 81%

Isolated Central Hypothyroidism in Short Stature

Rose

1995

Pediatr Res

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Section: Discussionmentioning

confidence: 81%

Isolated Central Hypothyroidism in Short Stature

Rose

1995

Pediatr Res

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“…1 It has long been known that the side effects which can occur include late thyroid complications, such as thyroid dysfunction [2][3][4][5][6][7][8][9] and thyroid cancer. [10][11][12][13] Thyroid dysfunction is rather frequent and has been mostly reported as a complication of irradiation, particularly for solid tumors, such as brain cancers 10,14 and Hodgkin lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Oudin¹,

Auquier²,

Bertrand³

et al. 2016

Haematologica

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T hyroid complications are known side effects of irradiation. However, the risk of such complications in childhood acute leukemia survivors who received either central nervous system irradiation or hematopoietic stem cell transplantation is less described. We prospectively evaluated the incidence and risk factors for thyroid dysfunction and tumors in survivors of childhood acute myeloid or lymphoid leukemia. A total of 588 patients were evaluated for thyroid function, and 502 individuals were assessed for thyroid tumors (median follow-up duration: 12.6 and 12.5 years, respectively). The cumulative incidence of hypothyroidism was 17.3% (95% CI: 14.1-21.1) and 24.6% (95% CI: 20.4-29.6) at 10 and 20 years from leukemia diagnosis, respectively. Patients who received total body irradiation (with or without prior central nervous system irradiation) were at higher risk of hypothyroidism (adjusted HR: 2.87; P=0.04 and 2.79, P=0.01, respectively) as compared with transplanted patients who never received any irradiation. Patients transplanted without total body irradiation who received central nervous system irradiation were also at higher risk (adjusted HR: 3.39; P=0.02). Patients irradiated or transplanted at older than 10 years of age had a lower risk (adjusted HR: 0.61; P=0.02). Thyroid malignancy was found in 26 patients (5.2%). Among them, two patients had never received any type of irradiation: alkylating agents could also promote thyroid cancer. The cumulative incidence of thyroid malignancy was 9.6% (95% CI: 6.0-15.0) at 20 years. Women were at higher risk than men (adjusted HR: 4.74; P=0.002). In conclusion, thyroid complications are frequent among patients who undergo transplantation after total body irradiation and those who received prior central nervous system irradiation. Close monitoring is thus warranted for these patients.

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“…In this study the findings are comparable with the previous study. 5,6,7,8,9,10 showing decreased levels of T3 in uremic and heamodialysis patients. This reduction in T3 concentration has been linked to the decrease in the peripheral synthesis of T3 from T4.…”

Section: Discussionmentioning

confidence: 95%

Comparative Study of Thyroid Abnormalities With Severity of Chronic Renal Failure

Shamsuddin¹,

Makandar²

2015

jemds

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BACKGROUND:Patients with CRF often have signs & symptoms suggestive of thyroid dysfunctions. Prevalence of hypothyroidism in patients with terminal renal failure is 5%, in comparison with that in hospitalized patients with normal renal function . CKD is associated with higher prevalence of hypothyroidism, both overt and subclinical, but not with hyperthyroidism. In fact, the prevalence of primary hypothyroidism is mainly in the subclinical form, which increases as GFR decreases. OBJECTIVES: To estimate thyroid hormone levels i.e. T3, T4 & TSH in CRF. To estimate Serum urea & creatinine for selection and categorizing the study subjects in to different grades of CRF. To study the thyroid hormone levels and thyroid abnormalities as the severity of CRF increases. MATERIALS AND METHODS:In this study 30 male patients of aged between 40-70yrs. with serum creatinine >5.5mg/dl & urea >55mg/dl and dipstick test positive for protein with symptoms of chronic renal failure are taken as cases. Age and sex matched normal healthy individuals are taken as controls. Serum Urea Estimated by DAM Method, serum creatinine is estimated by Jaffe's method and Serum levels of T3, T4 & TSH were analysed by using CLIA method. Results: T3, T4 decreases and TSH increases significantly in cases compare to the controls as the severity of dieses increases. In our study 10% of patients of CRF are hypothyroid and all these hypothyroid patients belongs to serum creatinine above 6 mg/dl category. CONCLUSION: Mean of T3, T4 decreases TSH increases significantly in cases compare to controls as the severity of CRF increases. The risk of hypothyroidism in chronic renal failure is very high if serum creatinine level are above 6 mg/dl.

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Evidence of hypothalamic-pituitary thyroid abnormalities in children with end-stage renal disease

Cited by 21 publications

References 25 publications

Isolated Central Hypothyroidism in Short Stature

Isolated Central Hypothyroidism in Short Stature

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Comparative Study of Thyroid Abnormalities With Severity of Chronic Renal Failure

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