Evidence of <i>in vivo</i> basophil activation in chronic idiopathic urticaria

Vasagar, Kavitha; Vonakis, Becky M.; Gober, Laura; Viksman, A.; Gibbons, Scott P.; Saini, Sarbjit S.

doi:10.1111/j.1365-2222.2006.02494.x

Cited by 91 publications

(83 citation statements)

References 43 publications

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“…An increasing number of studies has confirmed the usefulness of BAT with donor basophils in the diagnosis and pathogenetic elucidation of chronic urticaria [129,130,131,132,133,134,135,136,137,138]. …”

Section: Clinical Indications Of Batmentioning

confidence: 99%

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Weck

Sánz

Gamboa

et al. 2008

Int Arch Allergy Immunol

171

178

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For the diagnosis of allergy, cellular basophil activation tests (BAT), e.g. histamine or sulfidoleukotriene release tests, have long been introduced, but the expression of basophil activation markers such as CD63 and CD203c detected by flow cytometry has attracted more recent attention. A recent opinion paper in this Journal has stressed not only the potential but also the possible pitfalls of flow-cytometric BAT. We have applied clinical validation of various BAT in various ways for several years, and our experience shows that these new technologies have more potentials and perspectives than pitfalls. A comprehensive review of clinically validated studies on allergy to aeroallergens, insect venoms, latex, food allergens and drugs, e.g. myorelaxants, β-lactams, pyrazolones and non-steroidal anti-inflammatory drugs, as well as chronic urticaria shows clearly that even with different protocols, reproducible and meaningful results can be obtained. Although the available technologies may still be optimized and better standardized, there are no serious reasons to deprive allergic patients of clinically indicated BAT, which can be performed reliably by any laboratory with allergy and flow-cytometric capacity and expertise.

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Section: Clinical Indications Of Batmentioning

confidence: 99%

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Weck

Sánz

Gamboa

et al. 2008

Int Arch Allergy Immunol

171

178

View full text Add to dashboard Cite

show abstract

“…9,11 Upregulation of CD203c on peripheral blood basophils from patients with CU has also been described. 12 In the current study, we sought to compare the effect of sera from ASST 1 and ASST -patients with CU on basophil CD203c expression to normal control sera and to determine the correlation with BHR. In addition, IgG depletion of sera from ASST 1 individuals was performed to determine whether the mechanism of CD203c upregulation is IgG-mediated.…”

mentioning

confidence: 99%

Chronic urticaria sera increase basophil CD203c expression

Yasnowsky

Dreskin

Efaw

et al. 2006

Journal of Allergy and Clinical Immunology

102

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“…Diğer çalışmalarda tedaviye yanıt ve hastalık seyri ile ilişkisi bulunamamış olması da OST'nin güvenilirliğini şüpheye düşüren kanıtlar arasında yer almaktadır (14). (20). Bu çalışma sonuçları otoantikorların işlevsiz olduğu yönünde kanıtlar sunmaktadır.…”

Section: Patogenez Teorileri -Otoimmün Teori;unclassified