Evidence of improved immediate verbal memory and diminished category fluency following STN-DBS in Chinese-Cantonese patients with idiopathic Parkinson’s disease

Tang, Venus; Zhu, Cannon Xian Lun; Chan, Danny Tat Ming; Lau, CK; Chan, Anne; Mok, Vincent; Yeung, Jonas; Poon, Wai Sang

doi:10.1007/s10072-015-2117-1

Cited by 20 publications

(37 citation statements)

References 22 publications

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“…However, the study was not corrected for multiple analyses, and a post hoc correction was not possible due to the lack of reported p value, making it unclear if such a correction would have made the reported improvement statistically not significant. Tang et al did report such improvement, in a series of 27 patients followed for 12 months [ 73 ], in a study corrected for multiple analyses. Conversely, worsening in at least one measure of memory was reported in 5 studies, up to 16 months after DBS ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

Mehanna

Bajwa

Fernández

et al. 2017

Parkinson's Disease

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Subthalamic nucleus (STN) or globus pallidus interna (GPi) deep brain stimulation (DBS) is considered a robust therapeutic tool in the treatment of Parkinson's disease (PD) patients, although it has been reported to potentially cause cognitive decline in some cases. We here provide an in-depth and critical review of the current literature regarding cognition after DBS in PD, summarizing the available data on the impact of STN and GPi DBS as monotherapies and also comparative data across these two therapies on 7 cognitive domains. We provide evidence that, in appropriately screened PD patients, worsening of one or more cognitive functions is rare and subtle after DBS, without negative impact on quality of life, and that there is very little data supporting that STN DBS has a worse cognitive outcome than GPi DBS.

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Section: Resultsmentioning

confidence: 99%

Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

Mehanna

Bajwa

Fernández

et al. 2017

Parkinson's Disease

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“…To minimize practice effects, alternative forms of HK‐MoCA were used across different timepoints. Executive functioning was assessed by the Color‐Word Stroop Test and Category Verbal Fluency Test . Attention and the speed of information processing were measured by the Trail Making Test A/B (TMT), and the Forward and Backward Digit Span was used to measure working memory.…”

Section: Methodsmentioning

confidence: 99%

“…38 Stroop Test 41 and Category Verbal Fluency Test. 42 Attention and the speed of information processing were measured by the Trail Making Test A/B (TMT 43 ), and the Forward and Backward Digit Span 44 was used to measure working memory.…”

Section: Anhedonia-snaith-hamilton Pleasure Scale (Shaps)mentioning

confidence: 99%

High‐definition transcranial direct current stimulation—An open‐label pilot intervention in alleviating depressive symptoms and cognitive deficits in late‐life depression

et al. 2019

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The efficacy of high‐definition transcranial direct current stimulation (HD‐tDCS) in late‐life depression (LLD) remains unknown due to limited research on its therapeutic effects on the hallmarks of LLD—the depressive and cognitive symptoms. The present open‐label pilot study aimed to examine the effectiveness of HD‐tDCS as an augmentation therapy with antidepressants in improving the depressive and cognitive symptoms for LLD. Significant improvements were hypothesized in the depressive, cognitive, and daily functioning outcomes over time. A total of 15 subjects with LLD (13 females, mean age = 73.27 ± 6.25) received five consecutive daily sessions of 20‐minute active HD‐tDCS interventions weekly for 2 weeks, with a 2 mA anodal stimulation over F3 and cathodal stimulation over FC1, AF3, F7, and FC5. Depressive symptoms and cognitive and daily functioning were assessed across five assessment timepoints. The results revealed that the HD‐tDCS was effective in reducing the depressive severity and the remission rates, with a sustained effect at both the 1‐month and 3‐month follow‐up. Pre‐post improvements were seen in the overall cognitive functioning and in verbal fluency, but not in executive functioning. Our pilot study provides a preliminary result of HD‐tDCS in LLD, which was a safe and effective treatment in alleviating depressive symptoms, with mild cognitive improvements observed. Further larger scale randomized controlled trials are needed to confirm this result.

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“…On one hand, it has been reported that DBS could significantly improve immediate verbal memory and reduce anxiety symptoms [113]; on the other hand, it is also investigated that certain types of impaired domain such as attention impairment predicted more detrimental results after DBS [114]. Therefore, the improvements of cognitive symptoms from DBS require further studies and warrant the precise cognitive tests that stratify the relative risks and benefits of surgery.…”

Section: Treatmentmentioning

confidence: 99%

Parkinson’s Disease and Cognitive Impairment

Yang

Tang

Guo

2016

Parkinson's Disease

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Parkinson's disease (PD) is a progressive neurodegenerative disease primarily characterized by the hallmarks of motor symptoms, such as tremor, bradykinesia, rigidity, and postural instability. However, through clinical investigations in patients and experimental findings in animal models of Parkinson's disease for years, it is now well recognized that Parkinson's disease is more than just a motor-deficit disorder. The majority of Parkinson's disease patients suffer from nonmotor disabilities, for instance, cognitive impairment, autonomic dysfunction, sensory dysfunction, and sleep disorder. So far, anti-PD prescriptions and surgical treatments have been mainly focusing on motor dysfunctions, leaving cognitive impairment a marginal clinical field. Within the nonmotor symptoms, cognitive impairment is one of the most common and significant aspects of Parkinson's disease, and cognitive deficits such as dysexecutive syndrome and visuospatial disturbances could seriously affect the quality of life, reduce life expectancy, prolong the duration of hospitalization, and therefore increase burdens of caregiver and medical costs. In this review, we have done a retrospective study of the recent related researches on epidemiology, clinical manifestation and diagnosis, genetics, and potential treatment of cognitive deficits in Parkinson's disease, aiming to provide a summary of cognitive impairment in Parkinson's disease and make it easy for clinicians to tackle this challenging issue in their future practice.

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Evidence of improved immediate verbal memory and diminished category fluency following STN-DBS in Chinese-Cantonese patients with idiopathic Parkinson’s disease

Cited by 20 publications

References 22 publications

Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

High‐definition transcranial direct current stimulation—An open‐label pilot intervention in alleviating depressive symptoms and cognitive deficits in late‐life depression

Parkinson’s Disease and Cognitive Impairment

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