Evidence of Low-Level Dengue Virus Circulation in the South Region of Cameroon in 2018

Mouiche, Moctar M M; Ntumvi, Nkom F; Maptue, Victorine T; Tamoufé, Ubald; Albert, Bisse; Ndze, Valentine Ngum; Nwobegahay, Julius; Gillis, Amethyst; LeBreton, Matthew; McIver, David J; Ayukekbong, James A; Saylors, Karen; Rubin, Edward M.; Lange, Christian E.

doi:10.1089/vbz.2019.2531

Cited by 10 publications

(11 citation statements)

References 9 publications

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“…These data are in line with previous studies carried out in Cameroon that showed a high susceptibility of infants and children to dengue infection [9,11,14,16,31]. In fact, the quality of environment in which these children live and the applying of protecting measures against mosquitoes, play an important role in the child trend of dengue infection.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, concurrent infections with malaria were sporadically documented [11,18]. However, for the East region which is recognized as an endemic zone for malaria with evidence of Aedes invasion [19,20], no studies on dengue prevalence have been carried out yet.…”

Section: Discussionmentioning

confidence: 99%

“…In Cameroon, several studies have reported the presence of dengue infection in urban and rural areas [9][10][11][12][13][14][15][16]. Different dengue serotypes were also characterized in especially DENV-1, DENV-2, and DENV-3 serotypes in asymptomatic [17] and febrile patients [9,14].…”

Section: Introductionmentioning

confidence: 99%

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Prospective case-control study of dengue infection in some malaria and non-malaria patients consulting at the Bertoua Regional Hospital, East-Cameroon

Galani

Ayangma

Wouatedem

et al. 2021

Preprint

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In Cameroon, recent studies have documented several cases of dengue infection in some urban areas, but dengue-malaria coinfection malaria was little investigated, especially in the East region. From the 6th July to the 4th September 2020, a case-control study including 50 cases (malaria-positive subjects) and 90 controls (non-malaria subjects) was carried out at the Bertoua Regional Hospital. Participants were prospectively enrolled and administered with a questionnaire to record information such as age, sex, dwelling place, dengue knowledge, and the environment's quality. Blood specimens were then collected and screened for dengue infection using the NS1/IgG/IgM rapid diagnostic tests and hematological parameters were measured using a MINDRAY-type hemacytometer. Of the malaria patients, 14% (7/50) were tested positive for dengue fever against 66.66% for the controls (60/90). Most malaria patients had a secondary dengue infection (57.14%, 4/7) while most of the non-malaria patients faced a primary infection (61.66%, 37/60). In both groups, women were more exposed than men to dengue and there was a significant association between the dwelling place and dengue seropositivity. Moreover, young subjects <16 years old were significantly more associated with dengue than 16-30 years old (OR=16.24, P=0.042 for cases vs, OR=21, P=0.0001 for controls). The analysis of hematological parameters showed a significant decrease (P<0.001) in platelets in cases compared to control. These results suggest that dengue fewer targets malaria- than non-malaria patients with different serological characteristics in Bertoua city. However, co-infected patients demonstrated a greater clinical vulnerability than monoinfected patients, urging the need for epidemiological surveillance.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Prospective case-control study of dengue infection in some malaria and non-malaria patients consulting at the Bertoua Regional Hospital, East-Cameroon

Galani

Ayangma

Wouatedem

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Interestingly, DENV-2 was the second most abundant dengue serotype found while we only got two cases of DENV-1. In a previous study in Cameroon, DENV-1 was the only serotype found among febrile patients, even in Douala (14,42,43), however, at variable prevalence.…”

Section: Discussionmentioning

confidence: 70%

Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon

Tchetgna

Yousseu

Kamgang

et al. 2021

Preprint

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Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using RT-PCR on fragments of the 5 and 3 UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 176 cases (55%) were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.

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“…First, we excluded children with a positive mRDT from further consideration. While denguemalaria coinfections have been reported in other countries [7,38,39], this was expected to be a relatively infrequent occurrence. To explore this possibility, however, we tested 131 mRDT positive children at the Kasese site, only one (0.77%) of who had a positive IgM band on the dRDT; a prevalence similar to children with a negative mRDT (p = 0.53).…”

Section: Discussionmentioning

confidence: 96%

Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness

et al. 2020

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Background The spatial distribution and burden of dengue in sub-Saharan Africa remains highly uncertain, despite high levels of ecological suitability. The goal of this study was to describe the epidemiology of dengue among a cohort of febrile children presenting to outpatient facilities located in areas of western Uganda with differing levels of urbanicity and malaria transmission intensity. Methods Eligible children were first screened for malaria using rapid diagnostic tests. Children with a negative malaria result were tested for dengue using a combination NS1/IgM/IgG rapid test (SD Bioline Dengue Duo). Confirmatory testing by RT-PCR was performed in a subset of participants. Antigen-capture ELISA was performed to estimate seroprevalence. Results Only 6 of 1416 (0.42%) children had a positive dengue rapid test, while none of the RT-PCR results were positive. ELISA testing demonstrated reactive IgG antibodies in 28 (2.2%) participants with the highest prevalence seen at the urban site in Mbarara (19 of 392, 4.9%, p < 0.001). Conclusions Overall, these findings suggest that dengue, while present, is an uncommon cause of non-malarial, pediatric febrile illness in western Uganda. Further investigation into the eocological factors that sustain low-level transmission in urban settings are urgently needed to reduce the risk of epidemics.

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Evidence of Low-Level Dengue Virus Circulation in the South Region of Cameroon in 2018

Cited by 10 publications

References 9 publications

Prospective case-control study of dengue infection in some malaria and non-malaria patients consulting at the Bertoua Regional Hospital, East-Cameroon

Prospective case-control study of dengue infection in some malaria and non-malaria patients consulting at the Bertoua Regional Hospital, East-Cameroon

Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon

Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness

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