Evidence of similar organization of the chromosomes carrying the major histocompatibility complex in man and other primates

Garver, J.J.; Estop, A.; Khan, P. Meera; Balner, H.; Pearson, P. L.

doi:10.1159/000131492

Cited by 19 publications

(11 citation statements)

References 4 publications

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“…Our data fulfil this prediction and further substantiate the current notion that the chromosome banding similarity reflects the conservation of the homologous gene in different species, as have been shown by comparative gene mapping (Human Gene Mapping 5, 1979;Garver et al 1980). In this context, a recent report of Schroder et al (1980) may merit special attention, who suggested the immunoglobulin heavy chain (Igh) locus of the rat on chromosome 14, in spite of the fact that Igh locus of the mouse have been assigned to chromosome 12 but not to chromosome 17 coding for H-2 complex (Hengartner et al 1978;Meo et al 1980).…”

Section: Immunoselection Of the Hybrid Clonessupporting

confidence: 89%

Provisional chromosome assignment of the rat major histocompatibility complex.

Oikawa

Yoshida

Satoh

et al. 1983

The Japanese journal of genetics

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Somatic cell hybrids between an AKR mouse thymic lymphoma cell line and normal F344 rat spleen cells were isolated in order to assign the rat major histocompatibility complex (MHC) (RT1) to a specific chromosome. Six primary hybrid clones and 3 of their derivatives were examined for expression of the RT1 antigens on the cell surface by the complement-dependent cytotoxicity test and simultaneously for their karyotypes by the Hoechst 33258/quinacrine mustard double staining method. All of these hybrid clones consisted of 2 sets of mouse and 1 set of rat parental cells, with a preferential loss of rat chromosomes. A high degree of concordance was shown between the expression of the RT1 antigen and the presence or absence of rat chromosome 14 in the original 6 hybrid clones. This was confirmed in 1 spontaneous and 2 immunoselected RT1-negative segregants from RT1-positive clones. These results led us to propose that the rat MHC is located on chromosome 14.

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Section: Immunoselection Of the Hybrid Clonessupporting

confidence: 89%

Provisional chromosome assignment of the rat major histocompatibility complex.

Oikawa

Yoshida

Satoh

et al. 1983

The Japanese journal of genetics

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“…Nevertheless, more precise phylogenetic statements based on comparisons of the hominoid chromosomes have been surprisingly equivocal. These statements suffer from (1) the lack of any coherent phylogenetic perspective, derived from the intensely inductive mode of thought in comparative Garver et al (1977Garver et al ( , 1980; Henderson et al (1976a,b); Pearson et al ( , 1979. 2The homologies to chromosome 2 in humans have proven to be a problem.…”

Section: Chromosome Banding Patterns Of the Pongidaementioning

confidence: 99%

“…This decision was contradicted, however, by Garver et al (1977), who found that enzyme segregating with the banding homologs of all three genera of pongids. Pearson (1977) also initially reported that PGM3 was not segregating with its banding homolog (VI) in the gorilla; this has been reversed in Garver et al (1980). Pearson (personal communication) regards the letter assignment as correct and attributes the ambiguity to enzyme lability.…”

Section: Chromosome Banding Patterns Of the Pongidaementioning

confidence: 99%

Hominoid cytogenetics and evolution

Marks

1983

American J Phys Anthropol

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Much of the literature on the chromosomes of the Hominoidea exists in virtual isolation from both evolutionary theory and physical anthropology. Several unjustified speculations about hominoid affinities in the literature of cytogenetics may be attributed to the effects of this isolation. In this paper, the literature of comparative hominoid cytogenetics is reviewed, and that on chromosomal band patterns and repetitive DNA distributions relative to current evolutionary theory is discussed. These data are critically analyzed and shown to be more consistent with an orthodox hominoid phylogeny than with heterodox phylogenies. Rates and modes of karyotypic evolution are also discussed in an attempt to begin to assimilate the study of hominoid chromosomes within the framework of physical anthropology.The study of the the cytogenetics of primates has generated an enormous amount of information, which has not yet been assimilated into the main fabric of physical anthropology. The reasons are several: (1) The work has appeared in specialized cytogenetics journals; (2) the work has been done by researchers unfamiliar with the discipline of physical anthropology; (3)the interpretations do not have a coherent phylogenetic framework, and have produced heterodox conclusions; and (4) primate cytogenetics is frequently compromised by an unfamiliarity with the lingua franca of comparative life-science, the systematics of the animals being studied. This last point is important as the lack of facility with primate taxonomy undermines the researchers' credibility and obscures the meaning of comparative statements (Table 1).This review attempts to take what has been learned about the organization of the genetic material of the primate superfamily Hominoidea and to fit it within the generally accepted framework of catarrhine evolution. It also criticizes some of the existing interpretations of the cytogenetic data. The review is divided into five sections: (1) a discussion of the history and significance of hominoid chromosomes; (2) chromosomal banding homologies of the great apes and humans; (3) repetitive DNA sequences in these primates; (4) variation in rates of chromosomal evolution; and (5) a discussion of phylogenetic inference based upon chromosomal data.The following general evolutionary tenet is adopted for this review: Phylogenetic sister groups, closest relatives, are to be recognized by the sharing of derived traits, evolutionary novelties, not by the sharing of ancestral traits (Hennig, 1965;Simpson, 1975). The useful, if cumbersome, Hennigian lexicon is adopted to highlight this distinction.Finally, there is a subtle, but critical, difference between cytogeneticists and evolutionary biologists in use of the term «homology." In cytogenetics, homology is taken as phenetic similarity of chromosomes antecedent to phylogenetic reconstruction (the word "homoeology" refers to less phenetic similarity). Thus, Prakash (1982 p. 1529) write that «no homology could be found" among the Ychromosomes of the apes before the...

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“…MML 1,5,8. 11,12,19,and X (which are presumably homologs of HSA 1,5,8,II,12,19, and X. respectively) have been shown to carry the same syntenic groups Garver et al, 1978Garver et al, , 1980Pearson et al, 1978).…”

mentioning

confidence: 99%

Complex chromosome homologies between the rhesus monkey (<i>Macaca mulatta</i>) and man

Estop

Garver

Egozcue

et al. 1983

Cytogenet Genome Res

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The chromosome localization and gene synteny of soluble malate dehydrogenase (MDH1), soluble isocitrate dehydrogenase (IDH1), mitochondrial superoxide dismutase (SOD2), phosphoglucomutase-3 (PGM3), mitochondrial malate dehydrogenase (MDH2), (3-glucuronidase (GUSB ), nucleoside phosphorylase (NP), pyruvate kinase M2 (PKM2), hexosaminidase A (HEXA), inosine triphosphatase (ITPA), and N-acetyl-α-D-galactosaminidase (NAGA) were determined in the rhesus monkey using somatic cell hybrids. Comparison with the human and Pongidae syntenic groups shows that chromosome banding homologies do not always correlate with gene mapping data.

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Evidence of similar organization of the chromosomes carrying the major histocompatibility complex in man and other primates

Cited by 19 publications

References 4 publications

Provisional chromosome assignment of the rat major histocompatibility complex.

Provisional chromosome assignment of the rat major histocompatibility complex.

Hominoid cytogenetics and evolution

Complex chromosome homologies between the rhesus monkey (<i>Macaca mulatta</i>) and man

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