Evidence of timing effects on acupuncture: A functional magnetic resonance imaging study

Gao, Yanling; Lin, Zhicheng; Tao, Jing; Yang, Shanli; Chen, Ri; Jiang, Cai; Dong, Keng; Huang, Jia; Chen, Lidian

doi:10.3892/etm.2014.2056

Cited by 12 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its effects on brain activation and cerebral blood flow have been studied previously [ 50 , 51 ]. Previous studies have demonstrated a stronger activation in the ante meridiem condition than in the postmeridiem condition in both healthy and stroke subjects treated with acupuncture [ 51 ]. The duration time of acupuncture plays an important role in the brain activation patterns.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acupuncture on the Motor Function and White Matter Microstructure in Ischemic Stroke Patients

Wang

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Evidence shows that ischemic stroke can induce brain structural reorganization. Acupuncture is advised as an adjunct to mainstream rehabilitation after stroke. However, the effectiveness of acupuncture is inconsistent among previous studies. Fourteen ischemic patients were collected and divided into two groups: conventional treatment group (CG) and acupuncture treatment group (AG). The results of a Fugl-Meyer Assessment (FMA) and diffusion tensor imaging were collected before and after treatment. The AG exhibited a higher improvement in FMA than the CG. Repeated measures analysis of variance on diffusion data only found a significant main effect for scanning time point in all diffusion indices. In each group, a postpair t-test revealed that diffusion indices values were changed significantly after treatment intervention in the body of the corpus callosum and bilateral corticospinal tracts, the inferior longitudinal fasciculus, the inferior frontooccipital fasciculus, the superior longitudinal fasciculus, the forceps minor, the cingulum gyrus, and the thalamic radiation. However, there was no significant difference in the diffusion indices between the two groups. In conclusion, acupuncture had a better behavioral score than traditional medicine treatment. However, acupuncture did not significantly change WM in the AG compared to the CG as expected within one month after the intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Acupuncture on the Motor Function and White Matter Microstructure in Ischemic Stroke Patients

Wang

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Studies have shown that acupuncture of ST36 induces multiple activations of relevant brain regions, including the frontal lobe, temporal lobe, postcentral and cingulate gyri, insula, hypothalamus, hippocampus, and other limbic systems (32,33), but the results were based on relatively small sample size and heterogeneous. The present work is a meta-analysis summarizing task-based fMRI studies of ST36 acupuncture in healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Brain Activities Responding to Acupuncture at ST36 (zusanli) in Healthy Subjects: A Systematic Review and Meta-Analysis of Task-Based fMRI Studies

et al. 2022

View full text Add to dashboard Cite

PurposeStomach 36 (ST36, zusanli) is one of the important acupoints in acupuncture. Despite clinical functional magnetic resonance imaging (fMRI) studies of ST36 acupuncture, the brain activities and the neural mechanism following acupuncture at ST36 remain unclear.MethodsLiterature searches were conducted on online databases, including MEDLINE, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang database, WeiPu database, and China Biology Medicine, for task-based fMRI studies of acupuncture at ST36 in healthy subjects. Brain regions activated by ST36 acupuncture were systematically evaluated and subjected to seed-based d mapping meta-analysis. Subgroup analysis was conducted on control procedures, manual acupuncture, electrical acupuncture (EA), and acupuncture-specific activations. Meta-regression analysis was performed to explore the effects of needle retention time on brain activities following ST36 acupuncture stimulation. The activated brain regions were further decoded and mapped on large-scale functional networks to further decipher the clinical relevance of acupuncturing at ST36.ResultsA total of sixteen studies, involving a total of 401 right-handed healthy participants, that satisfied the inclusion criteria were included in the present meta-analysis. Meta-analysis showed that acupuncturing on ST36 positively activates the opercular part of the right inferior frontal gyrus (IFG.R), left superior temporal gyrus (STG.L), and right median cingulate/paracingulate gyri (MCG.R) regions. Needle retention time in an acupuncture session positively correlates with the activation of the left olfactory cortex, as shown in meta-regression analysis. Subgroup analysis revealed that EA stimulation may be a source of heterogeneity in the pooled results. Functional network mappings showed that the activated areas were mapped to the auditory network and salience network. Further functional decoding analysis showed that acupuncture on ST36 was associated with pain, secondary somatosensory, sound and language processing, and mood regulation.ConclusionAcupuncture at ST36 in healthy individuals positively activates the opercular part of IFG.R, STG.L, and MCG.R. The left olfactory cortex may exhibit positive needle retention time-dependent activities. Our findings may have clinical implications for acupuncture in analgesia, language processing, and mood disorders.Systematic Review Registrationhttps://inplasy.com/inplasy-2021-12-0035.

show abstract

“…Eight studies [32,33,39,40,42,44,47,49,54] have compared the differences in brain plasticity between stroke patients and HC and found that the modulation effect of acupuncture on stroke patients was more specific and more 8…”

Section: Factors Associated With the Brain Plasticity Ofmentioning

confidence: 99%

Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI

Zhang

et al. 2021

Neural Plasticity

View full text Add to dashboard Cite

Acupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation. Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic resonance imaging (MRI), as a noninvasive, high anatomical resolution technique, has been employed to investigate neuroplasticity on acupuncture in stroke patients from a system level. However, there is no review on the mechanism of acupuncture treatment for stroke based on MRI. Therefore, we aim to summarize the current evidence about this aspect and provide useful information for future research. After searching PubMed, Web of Science, and Embase databases, 24 human and five animal studies were identified. This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. We found that acupuncture reorganizes not only motor-related network, including primary motor cortex (M1), premotor cortex, supplementary motor area (SMA), frontoparietal network (LFPN and RFPN), and sensorimotor network (SMN), as well as default mode network (aDMN and pDMN), but also language-related brain areas including inferior frontal gyrus frontal, temporal, parietal, and occipital lobes, as well as cognition-related brain regions. In addition, acupuncture therapy can modulate the function and structural plasticity of post-stroke, which may be linked to the mechanism effect of acupuncture.

show abstract

Evidence of timing effects on acupuncture: A functional magnetic resonance imaging study

Cited by 12 publications

References 37 publications

The Effect of Acupuncture on the Motor Function and White Matter Microstructure in Ischemic Stroke Patients

The Effect of Acupuncture on the Motor Function and White Matter Microstructure in Ischemic Stroke Patients

Brain Activities Responding to Acupuncture at ST36 (zusanli) in Healthy Subjects: A Systematic Review and Meta-Analysis of Task-Based fMRI Studies

Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI

Contact Info

Product

Resources

About