Evidence of Torque teno virus (TTV) vertical transmission in swine

Martínez-Guinó, Laura; Kekarainen, Tuija; Segalés, Joaquím

doi:10.1016/j.theriogenology.2009.01.010

Cited by 48 publications

(46 citation statements)

References 23 publications

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“…TTSuVs are also found in seminal fluid, indicating the possibility of sexual transmission of infection [73]. TTSuV DNA has also been found in colostrum and stillborn piglets, indicating that vertical and transplacental or intrauterine transmission may contribute to the dissemination of the virus [14]. So, infection with TTSuV occurs early in life and leads to a progressive persistent infection, with viremia levels increasing with the age of the animals.…”

Section: Animal Ttvsmentioning

confidence: 99%

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Global impact of Torque teno virus infection in wild and domesticated animals

Mallus

Macera

Maggi

et al. 2015

J Infect Dev Ctries

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Infection with Torque teno viruses (TTVs) is not restricted to humans. Different domestic and wild animal species are naturally infected with species-specific TTVs worldwide. Due to the global spread of the infection, it is likely that essentially all animals are naturally infected with species-specific TTVs, and that co-evolution of TTVs with their hosts probably occurred. Although TTVs are potentially related to many diseases, the evidence of the widespread infection in healthy human and nonhuman hosts raised doubts about their pathogenic potential. Nonetheless, their role as superimposed agents of other diseases or as triggers for impairment of immune surveillance is currently under debate. The possible contribution of animal TT viruses to interspecies transmission and their role as zoonotic agents are currently topics of discussion.

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Section: Animal Ttvsmentioning

confidence: 99%

“…AVs are ubiquitous and highly prevalent worldwide [5,6]. They infect their hosts with multiple and often divergent strains [7,8] and are transmitted through multiple routes [9][10][11][12][13][14][15]. Infection with AVs probably occurs early in life [16] and leads to a progressive persistent infection of the natural host [17].…”

Section: Introductionmentioning

confidence: 99%

Global impact of Torque teno virus infection in wild and domesticated animals

Mallus

Macera

Maggi

et al. 2015

J Infect Dev Ctries

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“…The reason for such minor difference in prevalence rate, particularly for TTSuV2 is open to speculation. For example, it may be attributed to the high percentage of TTSuV2 positive sows as observed in this study, since it has been suggested that TTSuVs can be transmitted by both vertical and horizontal routes [5,13,24,30], and as a result of these events, it is likely that TTSuV2 is more widespread than TTSuV1 in this farm. Furthermore, it is likely that the slightly higher PCR sensitivity of TTSuV2 compared to that of TTSuV1 (550 versus 14 molecules per reaction) reported in our previous study [30] might have contributed to the higher detection rate of TTSuV2 observed in this study.…”

Section: Ttsuv2mentioning

confidence: 68%

“…TTSuV1 and TTSuV2 (TTSuVs) have been detected from serum, plasma, semen, faeces, colostrum, nasal secretion and various tissues [5,8,13,26,29,30] exclusively by Polymerase chain reaction (PCR), and different pig rearing countries have reported prevalence rate ranging from 24 to 100% [4,8,[14][15][16][17][24][25][26]. Limited longitudinal studies employing serum [17,26] and cross-sectional studies employing serum and tissues [1,8,9,27] have shown that TTSuV infection increases with age.…”

mentioning

confidence: 99%

Infection Dynamics of Torque Teno Sus Virus Types 1 and 2 in Serum and Peripheral Blood Mononuclear Cells

Tshering

Takagi

Deguchi

2012

The Journal of Veterinary Medical Science

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ABSTRACT. This study was carried out to investigate the presence of Torque teno sus virus types 1 (TTSuV1) and 2 (TTSuV2) in a longitudinally (14 to 150 days of age) collected paired pooled sera (pSE) and peripheral blood mononuclear cells (pPBMCs) using nested polymerase chain reaction. The detection rate of TTSuV1 in pSE increased from 14 to 90 days of age, but a progressive decline was observed from 120 to 150 days of age, while in pPBMC, a high value was maintained till the end of growing-finishing period. On the contrary, except in PBMCs at 30 days of age, high detection rates of TTSuV2 were found in both pSE and pPBMCs in all sampling ages. The detection rate of TTSuVs between pSE and pPBMCs was positively correlated at all sampling ages except for TTSuV1 at 150 days of age. This is the first study showing the presence of TTSuVs in PBMCs from pigs and describing the in vivo infection dynamics of TTSuV in paired sera and PBMCs during the entire growing and finishing periods of pigs reared in conventional farms.

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“…Such a high prevalence can be explained by the containment conditions that facilitates transmission (Deng et al 2000, Gerner et al 2000, Martínez-Guinó et al 2009) and the ubiquitous characteristic of TTV.…”

Section: Discussionmentioning

confidence: 99%

Interstitial nephritis of slaughtered pigs in the State of Mato Grosso, Brazil

et al. 2012

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This study evaluated histological lesions in kidney samples from pigs with nephritis in two slaughterhouses in the State of Mato Grosso, Brazil. Four hundred samples were subjected to histology, anti-porcine circovirus type 2 (PCV2) immunohistochemistry (IHC), anti-Leptospira sp. immunofluorescence (IF), and polymerase chain reaction (PCR) for PCV2, porcine parvovirus (PPV), and Torque teno virus type 1 and 2 (TTV1, TTV2) detection. Histological lesions were found in 81% of the samples, and mononuclear interstitial nephritis was the most frequent lesion (77.50%). A follicular pattern was observed in 40.97% of the interstitial nephritis lesions. PCV2, PPV, TTV1, and TTV2 were identified in the kidneys by PCR in 27.25%, 28.50%, 94%, and 87.5% of the samples, respectively. Leptospira sp. was not detected through IF. Infection by PCV2 (PCR) and the presence of histological lesions (P=0.008) and giant cells (P=0.0016) were significantly associated. An association was observed between the TTV2-TTV1 co-infection (P<0.0001) and the risk for pathogenesis. These findings indicated that PCV2, PPV, TTV1, and TTV2 were widely distributed among pigs in the local farms and that the presence of these agents should be considered in the differential diagnosis of kidneys with interstitial nephritis in pigs.

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Evidence of Torque teno virus (TTV) vertical transmission in swine

Cited by 48 publications

References 23 publications

Global impact of Torque teno virus infection in wild and domesticated animals

Global impact of Torque teno virus infection in wild and domesticated animals

Infection Dynamics of <i>Torque Teno Sus Virus</i> Types <i>1</i> and <i>2</i> in Serum and Peripheral Blood Mononuclear Cells

Interstitial nephritis of slaughtered pigs in the State of Mato Grosso, Brazil

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