Interstitial nephritis of slaughtered pigs in the State of Mato Grosso, Brazil

Abstract

<jats:p>This study evaluated histological lesions in kidney samples from pigs with nephritis in two slaughterhouses in the State of Mato Grosso, Brazil. Four hundred samples were subjected to histology, anti-porcine circovirus type 2 (PCV2) immunohistochemistry (IHC), anti-Leptospira sp. immunofluorescence (IF), and polymerase chain reaction (PCR) for PCV2, porcine parvovirus (PPV), and Torque teno virus type 1 and 2 (TTV1, TTV2) detection. Histological lesions were found in 81% of the samples, and mononuclear interstitial nephritis was the most frequent lesion (77.50%). A follicular pattern was observed in 40.97% of the interstitial nephritis lesions. PCV2, PPV, TTV1, and TTV2 were identified in the kidneys by PCR in 27.25%, 28.50%, 94%, and 87.5% of the samples, respectively. Leptospira sp. was not detected through IF. Infection by PCV2 (PCR) and the presence of histological lesions (P=0.008) and giant cells (P=0.0016) were significantly associated. An association was observed between the TTV2-TTV1 co-infection (P&lt;0.0001) and the risk for pathogenesis. These findings indicated that PCV2, PPV, TTV1, and TTV2 were widely distributed among pigs in the local farms and that the presence of these agents should be considered in the differential diagnosis of kidneys with interstitial nephritis in pigs.</jats:p>

Pathomorphology of spontaneous kidney lesions in slaughtered pigs

“…Renal lesion occur either as primary conditions like cystic kidneys, nephritis, parasitic conditions and neoplasms 6,11,12 or in association with other systemic infections like swine fever, porcine circoviral infections, leptorspirosis etc. [13][14][15][16] . In this backdrop, the present study was conducted to investigate the general occurrence of various spontaneous kidney lesions in slaughtered pigs and to understand their pathomorphology in detail.…”

Principais Alterações Em Órgãos De Suínos Em Abatedouro Sob Inspeção Federal

“…encontraram resultados semelhantes com o presente estudo em relação a condenações por abcessos que também foi uma das causas mais relevantes de condenação total dos 106.342 suínos abatidos no período de pesquisa pelos autores e tendo sido registrado frequência total de 25,67% de condenação total por abcessos disseminados. nefrite intersticial crônica, que se caracteriza por uma fibrose significativa, destruição de túbulos renais e do interstício e focos de infiltração de células mononucleares, sendo que os glomérulos ficam relativamente inalterados(FILHO et al, 2012). Neste caso a decisão sanitária, conforme cita o artigo 159 do RIISPOA os rins lesados devem ser condenados(BRASIL, 2020b).…”