Evidence that Estradiol Induces the Preovulatory LH Surge in Cattle by Increasing Pituitary Sensitivity to LHRH and then Increasing LHRH Release*

Kesner, James S.; Convey, E. M.; Anderson, C. R.

doi:10.1210/endo-108-4-1386

Cited by 99 publications

(56 citation statements)

References 27 publications

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“…4). The preovulatory gonadotrophin surges occur as a result of a positive feedback action of high concentrations of oestradiol-17ß acting on hypothalamus and pituitary (Kesner, Convey & Anderson, 1981). In the present study increasing concentrations of LH were accompanied by elevated oestradiol-17ß concentrations in 3 cows (B, C and H).…”

Section: Discussionsupporting

confidence: 48%

Hormone responses to exogenous GnRH pulses in post-partum dairy cows

Peters¹,

Pimentel²,

Ge³

1985

Reproduction

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Section: Discussionsupporting

confidence: 48%

Hormone responses to exogenous GnRH pulses in post-partum dairy cows

Peters¹,

Pimentel²,

Ge³

1985

Reproduction

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“…The conspicuous LH peak observed in steroid-treated steers on d 4 and(or) 5 was unexpected. Kesner et al (1981) recently reported that estrogen-treated steers exhibit an LH surge comparable to that of estrogen-treated cows if exogenous luteinizing hormone releasing hormone (LHRH) is also provided. Because LHRH was not administered in the present study, it remains to be determined whether the LH peak observed in implanted steers is a consistent feature of this model.…”

Section: Discussionmentioning

confidence: 99%

Pulsatile Luteinizing Hormone Secretion in the Castrate Male Bovine: Effects of Testosterone or Estradiol Replacement Therapy1

Schanbacher¹,

D’Occhio²,

Gettys³

1983

Journal of Animal Science

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“…The higher oestradiol concentration as a result of a larger number of follicles (M. M. Bevers & S. J. Dieleman, unpublished observations) possibly increases pituitary sensitivity to LH-releasing hormone (Kesner et al, 1981) more rapidly. However, potential effects of administered antibody against PMSG cannot be attributed to acci¬ dentally introduced differences between control and treated cows, since the variation of the PG-LH interval was evenly distributed in the respective experimental groups.…”

Section: Methodsmentioning

confidence: 99%

Effects of monoclonal antibody against PMSG administered shortly after the preovulatory LH surge on time and number of ovulations in PMSG/PG-treated cows

Dieleman¹,

Bevers²

1987

Reproduction

137

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Summary. Normally cyclic heifers received 2500 i.u. PMSG i.m. at Day 10 of the oestrous cycle and 15 mg prostaglandin (PG) i.m. 48 h later. From 30 h after PG the LH concentration in the peripheral blood was estimated every hour using a rapid RIA method which allowed the LH concentration to be known within 4 h. Monoclonal antibody against PMSG was injected in the jugular vein of 29 heifers at 4\m=.\8h after the maximum of the preovulatory LH peak; 28 heifers were not treated with anti-PMSG (controls). Peripheral blood concentrations of PMSG, LH, progesterone and oestradiol were compared. Ovaries were collected by ovariectomy at fixed times, 22\p=n-\30h after the LH peak, and numbers were counted of small (2\p=n-\10mm), large ( > 10 mm) and ovulated follicles, and of follicles with a stigma.In anti-PMSG-treated cows, the PMSG concentration fell sharply to non-detectable levels within 2 h of the treatment, indicating that PMSG was neutralized in these cows at the onset of final follicular maturation. In all cows, the concentration of oestradiol showed a significant decrease at about 8 h after the LH peak. After anti-PMSG treatment ovulations took place from 24 until 30 h after the LH peak, whereas in control cows follicles had already ovulated at or before 22 h and ovulations continued until 30 h. At 30 h 90% of the follicles had ovulated in anti-PMSG-treated cows vs 72% in the controls, resulting in 15 and 8 ovulations per cow respectively (P < 0\m=.\05).Also, administration of monoclonal antibody against PMSG synchronized final follicular maturation and shortened the period of multiple ovulations.In conclusion, neutralization of PMSG shortly after the preovulatory LH peak suppresses adverse effects of PMSG on final follicular maturation, leading to an almost 2-fold increase of the ovulation rate.

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Evidence that Estradiol Induces the Preovulatory LH Surge in Cattle by Increasing Pituitary Sensitivity to LHRH and then Increasing LHRH Release*

Cited by 99 publications

References 27 publications

Hormone responses to exogenous GnRH pulses in post-partum dairy cows

Hormone responses to exogenous GnRH pulses in post-partum dairy cows

Pulsatile Luteinizing Hormone Secretion in the Castrate Male Bovine: Effects of Testosterone or Estradiol Replacement Therapy1

Effects of monoclonal antibody against PMSG administered shortly after the preovulatory LH surge on time and number of ovulations in PMSG/PG-treated cows

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