“…Using this approach, an adaptive response to alkylation damage has been observed in Bacillus subtilis (114, 115), B. thuringiensis (116), Micro coccus luteus (117), and Streptomyces frodiae (118). Cell extracts from induced B. subtilis and M. lute us contain an increased level of 06_ methylguanine-DNA methyltransferase activity.…”