Evidence that nitric oxide modulates drinking behaviour

Calapai, Gioacchino; Squadrito, Francesco; Altavilla, Domenica; Zingarelli, Basilia; Campo, Giuseppe M.; Cilia, M.; Caputi, Achille P.

doi:10.1016/0028-3908(92)90038-q

Cited by 81 publications

(35 citation statements)

References 17 publications

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“…This suggestion is further supported by our observation that, at the onset of the L-NAM E treatment, nonspecific effects such as sedation, reduction in total fluid intake, and food consumption were observed. Our observations are in line with previous reports showing that intake of water is modulated by NO (Calapai et al, 1992) and that food consumption can be reduced by blocking NO formation with antagonists of NOS (Morley and Flood, 1991;Squadrito et al, 1993).…”

Section: Alcohol Drinking In Nnos ؊/؊ Micesupporting

confidence: 93%

The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol

et al. 2002

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In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol drinking behavior. Mice deficient in the nNOS gene (nNOS Ϫ/Ϫ) and wild-type control mice were submitted to a two-bottle free-choice procedure with either water or increasing concentrations of alcohol (2-16%) for 6 weeks. nNOS Ϫ/Ϫ mice did not differ in consumption and preference for low alcohol concentrations from wild-type animals; however, nNOS Ϫ/Ϫ mice consumed sixfold more alcohol from highly concentrated alcohol solutions than wild-type mice. Taste studies with either sucrose or quinine solutions revealed that alcohol intake in nNOS Ϫ/Ϫ and wild-type mice is associated, at least in part, with sweet solution intake but not with the taste of bitterness. When compared with wild-type mice, the nNOS Ϫ/Ϫ mice were found to be less sensitive to the sedative effects of ethanol as measured by shorter recovery time from ethanol-induced sleep and did not develop rapid tolerance to ethanol-induced hypothermia, although plasma ethanol concentrations were not significantly different from those of controls. Our findings contrast with previous reports that showed that nonselective NOS inhibitors decrease alcohol consumption. However, because alcohol consumption was suppressed in wild-type as well as nNOS Ϫ/Ϫ mice by the NOS inhibitor N G -nitro-L-arginine methyl ester, we conclude that the effect of nonselective NOS inhibitors on alcohol drinking is not mediated by nNOS. Other NOS isoforms, most likely in the periphery or other splice variants of the NOS gene, might contribute to the effect of nonselective NOS inhibitors on alcohol drinking. In summary, the nNOS gene is critically involved in the regulation of neurobehavioral effects of alcohol.

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Section: Alcohol Drinking In Nnos ؊/؊ Micesupporting

confidence: 93%

The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol

et al. 2002

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“…Central administration of Larginine, the precursor amino acid of NO, inhibited drinking in water-deprived rats [13,14]. Several studies have demonstrated that expression of neuronal NO synthase (nNOS) gene in the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON) is increased by osmotic stimuli such as dehydration [15,16] and salt loading [17,18].…”

Section: : 640±648]mentioning

confidence: 99%

“…Several studies have demonstrated that insulin deficiency induced diabetes causes alteration of hypothalamic transmitters and the gene expressions of neuropeptides [1±7]. These studies suggest that the alteration of monoamine and neuropeptides in the hypothalamus may play a role in the multiple behavioural and hormonal abnormalities in STZ-induced diabetic rats.Recent studies have demonstrated that nitric oxide (NO) may be associated with various functions of the central nervous system, including feeding [8±12] and drinking behaviour [13,14]. It has been demonstrated that both systemic administration of a competitive antagonist of NO synthase (NOS) and Diabetologia (1998) Summary Plasma arginine vasopressin (AVP) is known to be elevated in patients with uncontrolled insulin-dependent diabetes mellitus who have plasma hyperosmolality with hyperglycaemia.…”

mentioning

confidence: 99%

“…Recent studies have demonstrated that nitric oxide (NO) may be associated with various functions of the central nervous system, including feeding [8±12] and drinking behaviour [13,14]. It has been demonstrated that both systemic administration of a competitive antagonist of NO synthase (NOS) and Diabetologia (1998) Summary Plasma arginine vasopressin (AVP) is known to be elevated in patients with uncontrolled insulin-dependent diabetes mellitus who have plasma hyperosmolality with hyperglycaemia.…”

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confidence: 99%

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Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats

et al. 1998

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The peripheral administration of streptozotocin (STZ) causes marked hyperglycaemia, plasma hyperosmolality, hypoinsulinaemia, hyperphagia and polydipsia. In STZ-induced diabetic animals, insulin treatment reverses these symptoms. Several studies have demonstrated that insulin deficiency induced diabetes causes alteration of hypothalamic transmitters and the gene expressions of neuropeptides [1±7]. These studies suggest that the alteration of monoamine and neuropeptides in the hypothalamus may play a role in the multiple behavioural and hormonal abnormalities in STZ-induced diabetic rats.Recent studies have demonstrated that nitric oxide (NO) may be associated with various functions of the central nervous system, including feeding [8±12] and drinking behaviour [13,14]. It has been demonstrated that both systemic administration of a competitive antagonist of NO synthase (NOS) and Diabetologia (1998) Summary Plasma arginine vasopressin (AVP) is known to be elevated in patients with uncontrolled insulin-dependent diabetes mellitus who have plasma hyperosmolality with hyperglycaemia. Although osmotic stimuli cause an increase in nitric oxide synthase (NOS) activity as well as synthesis of AVP and oxytocin in the paraventricular (PVN) and supraoptic nuclei (SON), it is not known whether NOS activity in the hypothalamus changes in the diabetic patients who have plasma hyperosmolality with hyperglycaemia caused by insulin deficiency. Expression of the neuronal (n) NOS gene in the PVN and SON in streptozotocin (STZ)-induced diabetic rats was investigated by using in situ hybridization histochemistry and NADPH-diaphorase histochemical staining. Four weeks after intraperitoneal (i. p.) administration of STZ, male Wistar rats developed hyperglycaemia and plasma hyperosmolality. The expression of nNOS gene and NADPH-diaphorase staining in the PVN and SON remarkably increased in STZ-induced diabetic rats compared to control rats. Three weeks after administration of STZ, the diabetic rats were subcutaneously treated with insulin for 1 week, which resulted in significant suppression of the induction of nNOS, AVP and oxytocin gene expression in the PVN and SON. Furthermore, the induction of nNOS gene expression in the PVN and SON was suppressed in STZ-induced diabetic rats treated with phlorizin and diet to normalize hyperglycaemia without insulin treatment. These results suggest that upregulation of nNOS gene expression as well as AVP and oxytocin gene expression in the PVN and SON in STZ-induced diabetic rats may be associated with hyperglycaemia and plamsa hyperosmolality. [Diabetologia (1998) 41: 640±648]

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“…Initially recognized for a primary role in the relaxation of peripheral vasculature, NO has since been implicated in the control of several activities that are at least partially mediated by the preoptic area or hypothalamus (1,3,14). Nitric oxide may influence these behaviors through release of a variety of neurotransmitters and hormonesamong them, dopamine (13).…”

mentioning

confidence: 99%

A Nitric Oxide Synthesis Inhibitor Administered Into the Medial Preoptic Area Increases Seminal Emissions in an Ex Copula Reflex Test

Moses

Hull

1999

Pharmacology Biochemistry and Behavior

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Evidence that nitric oxide modulates drinking behaviour

Cited by 81 publications

References 17 publications

The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol

The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol

Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats

A Nitric Oxide Synthesis Inhibitor Administered Into the Medial Preoptic Area Increases Seminal Emissions in an Ex Copula Reflex Test

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