Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney disease

Philbrick, Diana J.; Bureau, Dominique; Collins, F. William; Holub, Bruce J.

doi:10.1046/j.1523-1755.2003.00869.x

Cited by 39 publications

(33 citation statements)

References 34 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isoflavones [25] and soy saponins [26] also have been implicated as the active ingredients in soy responsible for its beneficial effects on renal disease. In a recent study, an 8-week regimen of purified dietary genistein (the major soy isoflavone) reduced renal inflammation and oxidant damage in the Han:SPRD- cy rat [27].…”

Section: Discussionmentioning

confidence: 99%

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Sankaran¹,

Bankovic-Calic²,

Cahill³

et al. 2007

Nephron Exp Nephrol

View full text Add to dashboard Cite

Background/Aims: Dietary soy protein and flax oil retard kidney disease progression when initiated in the early stages of disease in several experimental models, including the Han:SPRD-cy rat. However, individuals with kidney disease often do not become aware of their condition until injury to the kidney is extensive. The objective of this study was to determine whether initiating these interventions in established disease would alter further progression of renal injury. Methods: Two-month-old adult male Han:SPRD-cy rats were given either a flax oil diet (7% flax oil), a soy protein diet (20% soy protein) or a control diet (7% corn oil, 20% casein) for 4 months. Renal disease progression was assessed by examining morphological, immunohistochemical and biochemical parameters. Results: Compared to controls, there was 21–24% less staining of proliferating cells, 21–24% less oxidative damage and 13–15% less renal inflammation in kidneys from rats given dietary soy protein and flax oil. Renal cystic growth and fibrosis and serum creatinine levels were not altered by these dietary treatments. Conclusions: Late intervention with dietary soy protein and flax oil reduces some disease-associated pathologies in established renal disease in Han:SPRD-cy rats. The potential benefits of the antioxidant and anti-inflammatory effects on ultimate renal disease outcome in the long term remains to be determined.

show abstract

Section: Discussionmentioning

confidence: 99%

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Sankaran¹,

Bankovic-Calic²,

Cahill³

et al. 2007

Nephron Exp Nephrol

View full text Add to dashboard Cite

show abstract

“…Rodent models have been used extensively to study the pathophysiology of renal cystic diseases, especially polycystic kidney disease. Rodent models have also been used for preclinical drug discovery studies, with evidence for inhibition of renal dysfunction and cyst growth using inhibitors of angiotensin-converting enzyme (ACE), tumor necrosis factor (TNF), and epidermal growth factor (EGF), and potassium citrate, and soyasaponin [13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Micro-MRI methods to detect renal cysts in mice

Kobayashi¹,

Kawamoto²,

Brechbiel³

et al. 2004

Kidney International

View full text Add to dashboard Cite

show abstract

“…S-III and soyasapogenol B monoglucuronide were marginally bioactive against colon cancer cells whereas S-I was not [36]. On the other hand, S-I may be useful in treatment of polycystic kidney disease [37]. Soyasaponin-enriched extracts or purified isolates of D. canadense might therefore prove to be valuable for management of various disorders.…”

Section: Fig (3) Structures Of S-iii Ddmp S-iii S-iii Al and Ddmpmentioning

confidence: 99%

Soyasaponins and Related Glycosides of Desmodium canadense and Desmodium illinoense

Taylor¹,

Sutherland²,

Richards³

2009

TONPJ

View full text Add to dashboard Cite

Seed extracts of Desmodium canadense (L.) DC., a native Canadian legume, were examined by HPLC and electrospray ionization mass spectrometry (LC/MS) for the presence of triterpenoid saponins of the oleanene type. An aqueous methanol extract, fractionated by use of a Diaion™ HP-20 macroporous resin, was found to possess soyasaponin III (soyasaponin Bb´) and the 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one conjugate of soyasaponin III (DDMP S-III) as major saponin components. Minor components were identified by LC/MS as C-24 aldehyde (sandosapogenol) derivatives, S-III al and DDMP S-III al. Soyasaponin I (soyasaponin Bb), soyasaponin VI (soyasaponin g) and dehydrosoyasaponin I (soyasaponin Be) were also found as minor components. These components were also detected in extracts obtained by Soxhlet extraction with water followed by partitioning into n-butanol. Extracts from foliage of greenhouse and field origins were essentially free of these saponins. Soyasaponin VI was the main seed saponin of Desmodium illinoense A. Gray whereas soyasaponin III and DDMP S-III were found as minor components. Components corresponding in molecular mass to C-22 glycosides of soyasaponin I and soyasaponin III were also detected in saponin-enriched extracts. Neither species was a good source of alkaloids.

show abstract

Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney disease

Abstract: Soyasaponin Bb can impede kidney enlargement and cyst growth in the pcy mouse model of PKD. Further studies are needed to determine its most effective dose and mechanism of action.

Cited by 39 publications

References 34 publications

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Micro-MRI methods to detect renal cysts in mice

Soyasaponins and Related Glycosides of Desmodium canadense and Desmodium illinoense

Contact Info

Product

Resources

About