Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue

Possible implications of leptin, adiponectin and ghrelin in the regulation of energy homeostasis by thyroid hormone

“…There is now evidence that thyroid hormone can negatively regulate leptin gene expression [11]. Interestingly, a negative correlation between the levels of T 3, T 4 , and leptin in plasma was also observed in our study, while no correlation was seen with body weight changes ( Table 2).…”

Impacts of the coexistence of diabetes and hypothyroidism on body weight gain, leptin and various metabolic aspects in albino rats

“…Based on these publications and the present study, it can be suggested that the decrease in serum leptin level may be attributed to the lack of the stimulatory effects of the lowered insulin level in diabetic and hypothyroid rats. In addition to the suppressing effects of insulin, many authors reported a positive correlation between thyroid hormones and leptin Kosova et al, 2008) and others revealed a negative correlation (Zabrocka, Klimek, & Swierczynski, 2006). In contrast, Sesmilo, Casamitjana, Halperin, Gomis, and Vilardell (1998) suggested that thyroid function per se is not a major determinant of plasma leptin levels.…”

Effects of Thyroid Hormone on the Adaptation in Short Bowel Syndrome

“…The dosage of the T 3 used in the present study was chosen in order to overcome transient hypothyroidism and was in concordance with the studies done on hepatocyte proliferation by Oren et al and also by Zabrocka et al in inducing hyperthyroidism from euthyroid state in the rats [18,19]. The method described by Zabrocka et al was taken in to consideration for the dosage interval in order to induce euthyroid state at the transient hypothyroid phase of SBS [19].…”