2013
DOI: 10.1007/s12031-013-0203-5
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Evidences for B6C3-Tg (APPswe/PSEN1dE9) Double-Transgenic Mice Between 3 and 10 Months as an Age-Related Alzheimer’s Disease Model

Abstract: Transgenic mouse has shown great advantages in the study of Alzheimer's disease (AD) and drug screening as AD develops rapidly resent years, while more detail information of these transgenic mice and experience of application are needed. To obtain the basic background information of the B6C3-Tg (APPswe/PSEN1dE9) double-transgenic mouse, which was reported with early onset AD, three- to ten-month-old B6C3-Tg AD mice and normal C57BL/6 mice were selected randomly to test the ability of learning memory by Morris … Show more

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Cited by 16 publications
(14 citation statements)
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“…5 [28]. Axial, coronal and sagittal PET images of 18 F-FP-DPAZn2 obtained in AD model and normal mice are shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…5 [28]. Axial, coronal and sagittal PET images of 18 F-FP-DPAZn2 obtained in AD model and normal mice are shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Morris water maze is the most common behavior tasks to determine cognitive function deficits as described previously [13]. There are four quadrants according to the design of water maze software system, one is the target quadrant with a platform and other three quadrants are peripheral quadrants.…”
Section: Morris Water Mazementioning
confidence: 99%
“…We had previously studied the contribution of serotonin, GABA, and NMDA glutamate brain receptors to the nootropic effect of the AF form of HLDF- 6 peptide by radioreceptor assay. These receptors are involved in the pathogenesis of various neurological disorders and chronic neurodegenerative diseases [ 33 , 34 ]. The effect of the AF of HLDF-6 peptide on the parameters of binding between radiolabeled ligands and NMDA receptors on hippocampal membranes and between GABA-A and 5HT2A serotonin receptors on the membranes of the prefrontal cortex in BALB/c mice was investigated.…”
Section: Discussionmentioning
confidence: 99%
“…The additional control group was used because several models of cognitive function were included in the experiment. An analysis of published data demonstrates that the learning and memory features in B6C3-Tg(APPswe,PSEN1de9)85Dbo mice have been evaluated mostly using spatial learning tests, while the other cognitive models have been studied insufficiently [ 18 , 19 ]. The findings obtained using the spatial learning tests demonstrate that the differences between B6C3-Tg+ and B6C3-Tg- mice are most pronounced in models exposed to a high stress level (e.g., in the Morris water maze rather than in the Barnes maze test) [ 20 ].…”
Section: Methodsmentioning
confidence: 99%