Evidências científicas sobre a hepatite Delta no Brasil: revisão integrativa da literatura

Abstract

Objective: Describe the level of scientific evidence on infections by the hepatitis Delta virus (HDV) in Brazil. Methods: Integrative literature review, with research in the databases of the Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Center on Health Sciences Information, Scientific Eletronic Library Online and Scopus, with analysis focusing on the leveling of the methodological rigor according to the model of Melnyk and Fineout-Overholt. Results: The search revealed an average of two publications a year between 1987 and 2017. We selected 33 articles, the majority (91%) presented level of evidence VI. The publications were concentrated in the area of tropical medicine (46%) and virology (15%). The authors of 85% of the studies were medical professionals and the most common design was the descriptive/cross-sectional (69.6%). Conclusion: Scientific literature on HDV infections in Brazil is focused on prevalence studies, showing incipiency regarding the production of studies with stricter guidelines, such as clinical trials. ResumoObjetivo: Descrever o nível de evidência científica sobre a infecção por vírus da hepatite Delta (VHD) no Brasil. Métodos: Revisão integrativa da literatura, com buscas realizadas nas bases de dados do Medical Literature Analysis and Retrieval System Online, Literatura Latino-americana e do Caribe em Ciências da Saúde, Scientific Eletronic Library Online e Scopus, com análise centrada no nivelamento do rigor metodológico de acordo com o modelo de Melnyk e Fineout-Overholt. Resultados: A busca revelou uma média de duas publicações por ano no intervalo entre 1987 e 2017. Foram selecionados 33 artigos, tendo a maioria (91%) apresentado nível de evidência VI. As publicações ficaram concentradas em periódicos da área de medicina tropical (46%) e virologia (15%). Dos trabalhos, 85% tinha profissional médico com autor e o delineamento mais encontrado foi o descritivo/transversal (69,6%). Conclusão: A produção científica sobre a infecção por VHD no Brasil está centrada em estudos de prevalência, mostrando-se incipiente quanto à produção de estudos com delineamentos mais rígidos como ensaios clínicos.

Hepatitis mortality in Brazil and regions, 2001–2020: temporal trend and spatial analysis

“…HDV infection only occurs in humans already infected with HBV, often leading to the rapid development of serious liver conditions such as cirrhosis, hepatocellular cancer, and fulminant hepatitis. Despite these high endemic indicators in the north of the country, this condition is still neglected by health services 27 .…”

Evidências científicas sobre hepatite B e infecção por SARS-CoV-2: revisão integrativa

“…The integrative review is one of the methods of evidence-based healthcare practice, and consists of gathering and synthesizing scientific production on a given topic in a systematic way in order to deepen knowledge on the subject. 9 The research was carried out from May to November 2022, following six methodological stages, established according to the literature, [9][10][11] as shown in figure 1. In the first stage, the guiding question was formulated: "What levels of scientific evidence are available in the studies produced on the relationship between chronic hepatitis B and SARS-CoV-2 infection?"…”

“…For the third stage, Table 1 proposed by Oliveira et al 11 was used to organize and present the results found, characterizing the studies according to the classification of levels of scientific evidence, according to the Melnyk and Fineout-Overholt model. 12 The classification being:…”

Panorama das hepatites virais: um estudo atual

“…No Egito chega a infectar cerca de 20,0% da população, na Ásia sua prevalência chega a 82,0%. Na América do Sul sua maior distribuição encontra-se na bacia amazônica, destacando-se a Amazônia ocidental brasileira onde observamos até 85,0% dos pacientes infectados (Oliveira et al, 2017).…”