Mineral prospectivity modelling (MPM) is an essential step in reducing cost and time at the reconnaissance stage of mineral exploration. In this paper, the MPM was conducted in the Shahr-e-Babak study area for porphyry copper prospectivity. For achieving this goal, the evidential layers, including geology, remote sensing, airborne geophysics, geochemistry, and elevation model, were used as the input of training models. Four machine learning methods, consisting of multilayer perceptron (MLP), Adaptive neuro fuzzy inference system (ANFIS), random forest (RF), and generalized regression neural network (GRNN), were used to generate the models. Then, the fractal method and the prediction area plot were applied to evaluate the models. The models were divided into low potential, moderate potential, and high potential zones. The effective weight of evidential layers was extracted using the P-A plot method. The weight of Cu anomalies, phyllic, argillic and iron oxide alterations, elevation data, PC1 geochemical anomalies, magnetic anomalies, and subvolcanic bodies were 0.71, 0.62, 0.49, 0.4, 0.32, 0.25, 0.25 and -0.49, respectively. In the next step, the weights were extracted for MLP, ANFIS, RF, and GRNN as 0.85, 0.78, 1.26, and 0.76, respectively. The statistical correlation coefficients between argillic, phyllic, and iron oxide alterations were calculated. In the final step, an integrated model was generated using machine learning methods. Then, the integrated model was divided into low, moderate, and high potential zones based on the fractal method. Favorable areas are located in the western and eastern parts of the study area based on the integrated model.