(±)-Evodiakine, A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa

Li, Yanhong; Peng, Li‐Yan; Li, Xiaonian; Zhao, Qin‐Shi; Li, Rong‐Tao; Wu, Xing‐De

doi:10.1007/s13659-016-0113-7

Cited by 9 publications

(2 citation statements)

References 11 publications

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“…Two pairs of rare indole-styrene hybrid derivatives 141a/141b and 142a/142b were isolated from Isatis indigotica [91]. The rearranged rutaecarpine-type indole alkaloid enantiomers 143a/143b from Evodia rutaecarpa incorporate an unprecedented 6/5/5/7/6 skeleton [92]. The dimeric isoechinulin-type indole alkaloid enantiomers 144a/144b and 145a/145b from Uncaria rhynchophylla feature an intriguing and complex skeleton with a symmetrical cyclobutane ring, and their rel.…”

Section: Indole Alkaloidsmentioning

confidence: 99%

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Capon

et al. 2022

Molecules

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The knowledge that natural products (NPs) are potent and selective modulators of important biomacromolecules (e.g., DNA and proteins) has inspired some of the world’s most successful pharmaceuticals and agrochemicals. Notwithstanding these successes and despite a growing number of reports on naturally occurring pairs of enantiomers, this area of NP science still remains largely unexplored, consistent with the adage “If you don’t seek, you don’t find”. Statistically, a rapidly growing number of enantiomeric NPs have been reported in the last several years. The current review provides a comprehensive overview of recent records on natural enantiomers, with the aim of advancing awareness and providing a better understanding of the chemical diversity and biogenetic context, as well as the biological properties and therapeutic (drug discovery) potential, of enantiomeric NPs.

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Section: Indole Alkaloidsmentioning

confidence: 99%

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Capon

et al. 2022

Molecules

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“…Daphniphyllum alkaloids are a structurally diversified group of complex polycyclic natural products isolated from the Daphniphyllum genus [8]. Since these unique, versatile and complex nitrogen heterocyclic compounds exhibit a wide range of biological activities and are extremely challenging, they have aroused great interest in total synthesis and biosynthetic studies [9][10][11][12][13][14][15][16]. In recent years, quite a number of new Daphniphyllum alkaloids have been isolated and identified, and some of them possessed novel skeletons [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

Zhang

et al. 2021

Nat. Prod. Bioprospect.

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One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC50 of 31.9 μM. Graphic Abstract

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Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

Xiao¹,

Xu²,

Chen³

et al. 2023

Nat. Prod. Bioprospect.

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Euodiae Fructus, referred to as “Wuzhuyu” in Chinese, has been used as local and traditional herbal medicines in many regions, especially in China, Japan and Korea, for the treatment of gastrointestinal disorders, headache, emesis, aphtha, dermatophytosis, dysentery, etc. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this plant has been focused on the different structural types of alkaloids like evodiamine, rutaecarpine, dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone, which exhibit a wide range of pharmacological activities in preclinical models, such as anticancer, antibacterial, anti-inflammatory, anti-cardiovascular disease, etc. This review summarizes the up-to-date and comprehensive information concerning the botany, traditional uses, phytochemistry, pharmacology of Euodiae Fructus together with the toxicology and quality control, and discusses the possible direction and scope for future research on this plant.

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(±)-Evodiakine, A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa

Cited by 9 publications

References 11 publications

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

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