Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly

Ding, Wenwen; Ding, Zhiquan; Wang, Yong; Zhu, Yan; Gao, Qi; Cao, Wangsen; Du, Ronghui

doi:10.3389/fphar.2020.573870

Cited by 27 publications

(25 citation statements)

References 59 publications

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“…The therapeutic effects of cardamonin, evodiamine, walnut oil, and palmatine have been demonstrated in experimental mouse models of colitis as well. Their anti-inflammatory effects are related to their antioxidant properties, activation of autophagy, promotion of mitophagy, and inhibition of apoptosis ( Wang et al, 2018 ; Mai et al, 2019 ; Ding et al, 2020 ; Miao et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021

Zhang

Tian

et al. 2022

Front. Pharmacol.

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Background: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease with repeated relapses and remissions. Despite decades of effort, numerous aspects, including the initiating event and pathogenesis of UC, still remain ambiguous, which requires ongoing investigation. Given the mass of publications on UC, there are multidimensional challenges to evaluating the scientific impact of relevant work and identifying the current foci of the multifaceted disease. Accordingly, herein, we aim to assess the global growth of UC research production, analyze patterns of research areas, and evaluate trends in this area.Methods: The Web of Science Core Collection of Clarivate Analytics was searched for articles related to UC published from 2011 to 2021. Microsoft Office Excel 2019 was used to visualize the number of publications over time. Knowledge maps were generated using CiteSpace and VOSviewer to analyze collaborations among countries, institutions, and authors and to present the journey of UC research as well as to reveal the current foci of UC research.Results: A total of 5,088 publications were evaluated in the present study. China had the most publications (1,099, 22.5%). Univ Calif San Diego was the most productive institution (126, 2.48%). William J Sandborn published the greatest number of articles (100, 1.97%). Toshifumi Hibi was the most influential author in the field with a betweenness centrality of 0.53. Inflammatory bowel diseases was identified as the most prolific journal (379, 7.45%). Gastroenterology was the most co-cited journal (3,730, 4.02%). “Vedolizumab,” “tofacitinib,” “Faecalibacterium prausnitzii,” “fecal microbiota transplantation (FMT),” “toll-like receptor 4,” and “nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome” were considered the hot topics.Conclusion: In UC research, manuscripts that had high impacts on the scientific community provided an evidence base. UC therapy has entered the era of personalized and precision therapy. As research on FMT, anti-integrin antibodies, Janus kinase inhibitors, and anti-tumor necrosis factor drugs continues to grow, their use in the clinical setting may also expand.

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Section: Discussionmentioning

confidence: 99%

Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021

Zhang

Tian

et al. 2022

Front. Pharmacol.

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“…The proteins were separated on 10% SDS-PAGE gel and transferred to PVDF membranes. They were blocked with 5% nonfat milk for 2 h in a shaker at room temperature, then incubated with primary antibodies overnight at 4 °C, and incubated with secondary antibodies the next day [ 68 ]. Western blots were visualized using ECL electrochemiluminescence (Vazyme, Nanjing, China) and the quantities of proteins were analyzed by Image J software.…”

Section: Methodsmentioning

confidence: 99%

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels

Zong-ze

Zhang

et al. 2022

IJMS

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Atherosclerosis, accompanied by inflammation and metabolic disorders, is the primary cause of clinical cardiovascular death. In recent years, unhealthy lifestyles (e.g., sedentary lifestyles) have contributed to a worldwide epidemic of atherosclerosis. Exercise is a known treatment of atherosclerosis, but the precise mechanisms are still unknown. Here, we show that 12 weeks of regular exercise training on a treadmill significantly decreased lipid accumulation and foam cell formation in ApoE−/− mice fed with a Western diet, which plays a critical role in the process of atherosclerosis. This was associated with an increase in β-hydroxybutyric acid (BHB) levels in the serum. We provide evidence that BHB treatment in vivo or in vitro increases the protein levels of cholesterol transporters, including ABCA1, ABCG1, and SR-BI, and is capable of reducing lipid accumulation. It also ameliorated autophagy in macrophages and atherosclerosis plaques, which play an important role in the step of cholesterol efflux. Altogether, an increase in serum BHB levels after regular exercise is an important mechanism of exercise inhibiting the development of atherosclerosis. This provides a novel treatment for atherosclerotic patients who are unable to undertake regular exercise for whatever reason. They will gain a benefit from receiving additional BHB.

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“…Two recent studies found that EVO ameliorated experimental colitis, at least partially, by regulating the activation of the NLRP3 inflammasome. The effect of EVO on the inflammasome was associated with its role in regulating the activity of NF-kand autophagy [ 95 , 96 ]. However, the impact of EVO on NLRP3 inflammasome might be dependent on environmental factors, since a study by Li et al [ 97 ] showed that EVO might enhance anti-bacterial responses by augmenting the activation of NLRP3 inflammasome.…”

Section: Inhibition Of the Nlrp3 Inflammasome Ameliorates Colitismentioning

confidence: 99%

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

Zhou

Strober

et al. 2021

Molecules

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Inflammasomes are multiprotein complexes formed to regulate the maturation of pro-inflammatory caspases, in response to intracellular or extracellular stimulants. Accumulating studies showed that the inflammasomes are implicated in the pathogenesis of inflammatory bowel disease (IBD), although their activation is not a decisive factor for the development of IBD. Inflammasomes and related cytokines play an important role in the maintenance of gut immune homeostasis, while its overactivation might induce excess immune responses and consequently cause tissue damage in the gut. Emerging studies provide evidence that some genetic abnormalities might induce enhanced NLRP3 inflammasome activation and cause colitis. In these cases, the colonic inflammation can be ameliorated by blocking NLRP3 activation or its downstream cytokine IL-1β. A number of natural products were shown to play a role in preventing colon inflammation in various experimental colitis models. On the other hand, lack of inflammasome function also causes intestinal abnormalities. Thus, an appropriate regulation of inflammasomes might be a promising therapeutic strategy for IBD intervention. This review aims at summarizing the main findings in these studies and provide an outline for further studies that might contribute to our understanding of the role of inflammasomes in the pathogenesis and therapeutic treatment of IBD.

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Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly

Cited by 27 publications

References 59 publications

Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021

Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

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