Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

Padmanabhapillai, Ajayan; Tang, Yongqiang; Ranganathan, Mohini; Rangaswamy, Madhavi; Jones, Kevin; Chorlian, David B.; Kamarajan, Chella; Stimus, Arthur T.; Kuperman, Samuel; Rohrbaugh, John; O’Connor, Sean; Bauer, Lance O.; Schuckit, Marc A.; Begleiter, Henri; Porjesz, Bernice

doi:10.1016/j.ijpsycho.2006.05.012

Cited by 36 publications

(33 citation statements)

References 102 publications

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“…Neuroimaging studies using attentional tasks have implicated the role of frontoparietal networks in this top-down control of selective attention (Corbetta et al, 2000; Giesbrecht et al, 2003). Early gamma (28–45 Hz) band response (1–150 ms) is significantly attenuated in the frontal region for target processing in abstinent alcoholics (Padmanabhapillai et al, 2006a) and children of alcoholics (HR) (7–17 years) (Padmanabhapillai et al, 2006b). Differences were only seen in the parietal region for the target condition in HR individuals.…”

Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.

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Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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“…Another study, using magnetoencephalography (MEG) has shown that ingestion of 0.8 g/kg dose of alcohol increased peak amplitude and decreased peak frequency of visual grating and finger abduction paradigms-induced gamma band EEG activity [100]. Interestingly, it has also been reported that the early evoked gamma band response in the frontal and parietal regions during target stimulus processing is significantly less in male adolescent subjects, with a high risk for alcoholism, compared to normal control subjects [101]. This finding suggests that the deficient early-evoked gamma band response may precede the development of AUD and could be a potential endophenotypic marker of AUD risk.…”

Section: Alterations In Eeg Activity In Healthy Adults and Adults mentioning

confidence: 99%

Mechanisms underlying sleep–wake disturbances in alcoholism: Focus on the cholinergic pedunculopontine tegmentum

Knapp

Ciraulo

Datta

2014

Behavioural Brain Research

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Sleep-wake (S-W) disturbances are frequently associated with alcohol use disorders (AUD), occurring during periods of active drinking, withdrawal, and abstinence. These S-W disturbances can persist after months or even years of abstinence, suggesting that chronic alcohol consumption may have enduring negative effects on both homeostatic and circadian sleep processes. It is now generally accepted that S-W disturbances in alcohol-dependent individuals are a significant cause of relapse in drinking. Although significant progress has been made in identifying the socio-economic burden and health risks of alcohol addiction, the underlying neurobiological mechanisms that lead to S-W disorders in AUD are poorly understood. Marked progress has been made in understanding the basic neurobiological mechanisms of how different sleep stages are normally regulated. This review article in seeking to explain the neurobiological mechanisms underlying S-W disturbances associated with AUD, describes an evidence-based, easily testable, novel hypothesis that chronic alcohol consumption induces neuroadaptive changes in the cholinergic cell compartment of the pedunculopontine tegmentum (CCC-PPT). These changes include increases in N-methyl-D-aspartate (NMDA) and kainate receptor sensitivity and a decrease in gamma-aminobutyric acid (GABAB) - receptor sensitivity in the CCC-PPT. Together these changes are the primary pathophysiological mechanisms that underlie S-W disturbances in AUD. This review is targeted for both basic neuroscientists in alcohol addiction research and clinicians who are in search of new and more effective therapeutic interventions to treat and/or eliminate sleep disorders associated with AUD.

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“…S-transform (Stockwell et al, 1996) is an effi cient method for extracting estimates of localized power of nonstationary evoked potentials and has been extensively used in prior alcoholism studies (Kamarajan et al, 2006;Padmanabhapillai et al, 2006;Rangaswamy et al, 2007). S-transform is a generalization of the short-time Fourier transform with a variable-length Gaussian window function sliding across time at different frequency scales.…”

Section: Event-related Oscillationsmentioning

confidence: 99%

“…We used a time window of 300-700 ms for the theta (4-8 Hz) and alpha (8.15-12 Hz) bands. TF distributions were baseline adjusted (Kamarajan et al, 2006;Padmanabhapillai et al, 2006) by subtracting the mean prestimulus amplitude from the poststimulus values within the time window of interest.…”

Section: Event-related Oscillationsmentioning

confidence: 99%

Effects of Memantine on Event-Related Potential, Oscillations, and Complexity in Individuals With and Without Family Histories of Alcoholism

Narayanan

Stevens

Jiantonio

et al. 2013

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Enhanced N-methyl-D-aspartate (NMDA) receptor function associated with a positive family history of alcoholism (FHP) has been hypothesized to contribute to the heritable risk for alcoholism. The objective of this study was to evaluate the relationship of alcoholism family history, NMDA receptor function, and cortical information processing by testing acute effects of the NMDA receptor antagonist memantine on event-related potential (ERP). Method: Twenty-two healthy FHP and 20 healthy family history-negative (FHN; no alcoholic relatives) subjects were administered placebo or 40 mg of memantine under double-blind counterbalanced conditions on two separate occasions. Electroencephalogram data were collected from eight channels with eyes open during an auditory oddball discrimination task. We evaluated P3b amplitude, total theta, alpha activity, and fractal dimension from ERP trials. Results: FHP and FHN subjects did not differ in P3b amplitude. A signifi cant Group × Drug interaction was observed in theta, alpha activity, and fractal dimension at the parietal and occipital sites. FHP individuals exhibited signifi cantly higher fractal dimension and lower theta and alpha activity after placebo relative to FHN subjects. Following memantine administration, theta activity decreased in both groups but more markedly for FHN individuals. Alpha activity decreased for FHN subjects and increased for FHP individuals, whereas the fractal dimension decreased for FHP subjects and increased for FHN subjects after memantine.

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Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

Cited by 36 publications

References 102 publications

Understanding alcohol use disorders with neuroelectrophysiology

Understanding alcohol use disorders with neuroelectrophysiology

Mechanisms underlying sleep–wake disturbances in alcoholism: Focus on the cholinergic pedunculopontine tegmentum

Effects of Memantine on Event-Related Potential, Oscillations, and Complexity in Individuals With and Without Family Histories of Alcoholism

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