Evoked Otoacoustic Emissions from Ears with Idiopathic Sudden Deafness

Sakashita, Tetsushi; Minowa, Yasuhiro; Hachikawa, Kouji; Kubo, Takeshi; Nakai, Yousuke

doi:10.3109/00016489109134984

Cited by 29 publications

(21 citation statements)

References 6 publications

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“…Since the pathophysiology of ISSHL intuitively resulted in hair cell damage due to vascular compromise or viral infection, it is reasonable to use OAEs as a prognostic factor for ISSHL. However, there are only three studies that have reported the OAEs as a prognostic factor in ISSHL patients [Sakashita et al, 1991;Lalaki et al, 2001;Hoth, 2005]. All results are subject to small sample size and the failure of adjusting for other established confounding factors.…”

Section: Introductionmentioning

confidence: 89%

Distortion Product Otoacoustic Emissions as a Prognostic Factor for Idiopathic Sudden Sensorineural Hearing Loss

Chao

Chen²

2006

Audiol Neurotol

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We investigated distortion product otoacoustic emissions (DPOAE) as a prognostic factor in idiopathic sudden sensorineural hearing loss (ISSHL) patients with the time-dependent Cox proportional-hazards model. We also compared the importance of the prognostic factors that are reported in the literature. 108 patients with ISSHL were included. Both DPOAE and pure tone audiometry were performed everyday for a maximum of 7 days during admission and followed every other week or monthly after discharge. All DPOAE amplitudes were analyzed at 2f1-f2 – namely 1093, 1375, 1750, 2187, 2781, 3500, 4375, and 5500 Hz. The average of two series of DPOAE intensity corrected for the noise level in eight frequencies was coded as dichotomous at ≧6 or <6 dB. We selected the most updated DPOAE at 3 days or more before the assessment of recovery into the analysis. The potential confounders including age, sex, history of vertigo at onset, history of hypertension, diabetes, coronary arterial disease, and stroke, configuration and severity of initial pure tone audiometry, the duration from onset to treatment, auditory brainstem response (ABR), vestibular evoked myogenic potential (VEMP), and plasma triglyceride and cholesterol levels, hemoglobin level, and erythrocyte sedimentation rate were collected for evaluation. The results showed that a better DPOAE amplitude was a significantly good prognostic indicator both in univariate analysis (recovery rate ratio = 3.626, 95% CI = 2.119–6.205, p < 0.0001) and multivariate analysis (recovery rate ratio = 2.94, 95% CI = 1.537–5.624, p = 0.0011). The Kaplan-Meier estimates showed that the younger age group (≤40 years) with better initial pure tone audiometry (<65 dB) represented a better prognosis that was compatible with previous literature (log-rank test, p = 0.0297 and p = 0.0019 respectively). In the univariate analysis, normal ABR and VEMP waveforms were associated with a better prognosis (ABR: recovery rate ratio = 2.984, 95% CI = 1.742–5.112, p < 0.0001; VEMP: recovery rate ratio = 1.978, 95% CI = 1.183–3.305, p = 0.0093). The configuration of initial audiometry was also a significant prognostic factor that patients with scale-out type (recovery rate ratio = 0.228, 95% CI = 0.089–0.584, p = 0.002) and tent type (recovery rate ratio = 0.081, 95% CI = 0.008–0.778, p = 0.0295) were associated with a poorer prognosis than those with the flat type in the multivariate analysis. In this study, the time-dependent Cox proportional-hazards model established the prognostic value of DPOAE for ISSHL patients. This model can also be used for comparison of different treatment protocols. In addition, the further development of a predictive model based on this method is worthy of being investigated.

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Section: Introductionmentioning

confidence: 89%

Distortion Product Otoacoustic Emissions as a Prognostic Factor for Idiopathic Sudden Sensorineural Hearing Loss

Chao

Chen²

2006

Audiol Neurotol

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“…Overall good results were reported in 77% of patients with tinnitus and various diseases immediately after the intratympanic dexamethasone treatment [21] and found that the best results of intratympanic therapy for tinnitus are obtained in patients with a shorter duration of tinnitus, especially when treatment was initiated within 3 months of symptom onset [17]. The effectiveness of intratympanic injection of prednisolone or dexamethasone to treat subjective tinnitus was reported to be 48.6 and 37.5%, respectively [22].…”

Section: Discussionmentioning

confidence: 99%

“…There are studies in the literature that demonstrate a prognostic role for OAEs in the ISSHL [21,26].…”

Section: Discussionmentioning

confidence: 99%

Intratympanic Drug Delivery for Tinnitus Treatment

Barreto¹,

Ledesma²,

Boger³

et al. 2017

Up to Date on Meniere's Disease

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Objective: The aim of the study to evaluate the effectiveness of oral and injection intratympanic methylprednisolone to treat acute tinnitus associated with idiopathic sudden sensorineural hearing loss. Study design:Analytical, prospective and longitudinal study.Setting: Brasilia Institute of Otorhinolaryngology. Subjects and methods:Twenty-three subjects with acute tinnitus and idiopathic sudden sensorineural hearing loss, 13 treated with oral steroids only (Group 1) and 10 treated with methylprednisolone intratympanic injection as rescue therapy (Group 2), and evaluated by audiometry, otoacoustic emission, tinnitus handicap inventory (THI) and visual analog scale (VAS) to assess the degree of tinnitus annoyance, before treatment and after 3 months. Results:The annoyance due to tinnitus resulted in a mean VAS of 7.69 in the beginning of treatment and 5.15 3 months after treatment (Group 1), and 8.30 at the beginning and 6.00 3 months later (Group 2). In THI, average was 64.77 points at the beginning of treatment and 49.92 points 3 months later (Group 1) and 72.20 points at the beginning and 51.60 points after 3 months (Group 2). The results of audiometry and otoacoustic emissions showed significant improvement in both groups with significant differences intragroups before and after, but not between the groups. Conclusion:The results suggest that both oral and injection intratympanic methylprednisolone are effective treatment for acute tinnitus associated with idiopathic sudden sensorineural hearing loss in these patients.

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“…[1,2]. Grundsätzlich besteht Übereinstimmung darin, dass TEOAE bei einem Hörverlust von 40 dB oder mehr bei 1 kHz und bei einem mittleren Hörverlust (bei 0,5, 1, 2 und 4 kHz) von 135 dB nicht mehr registriert werden können [3][4][5][6][7][8][9].…”

TEOAE-Messungen zur Verlaufsbeurteilung akuter kochleovestibulärer Störungen: methodische Aspekte

Nölle¹,

Wunder²,

Ernst³

2000

Otorhinolaryngol Nova

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Ziel der vorliegenden Arbeit ist es, mit Hilfe von TEOAE-Messungen (TEOAE = transiently evoked otoacoustic emissions) bei ausgewählten otologischen Erkrankungen (Hörsturz und M. Ménière) Schlussfolgerungen zum Verlauf und gegebenenfalls zur Prognose dieser Erkrankungen unter besonderer Berücksichtigung der methodischen Auswertungsverfahren ziehen zu können. Es wurden bei 46 Patienten vor Therapiebeginn, nach 3 und 9 Tagen sowie nach 1 und 2 Monaten ein Reintonaudiogramm angefertigt und TEOAE-Messungen durchgeführt. Die wichtigsten TEOAE-Befunde waren die frühzeitige Zunahme der Amplitude vor einem Hörschwellenanstieg beim klassischen Morbus Ménière (Stadium I) sowie die frühzeitige Zunahme der Amplitude und der Reproduzierbarkeit beim kochleären M. Ménière (Stadium II). TEOAE-Parameter könnten somit Indikatorfunktion für die Erholung des Gehörs haben. Beim Hörsturz trifft dieses nicht zu, was eine wesentliche Ursache in der ungeklärten Ätiopathogenese der Erkrankung haben könnte. Die statistische Auswertung eines Patientenkollektives ermöglicht eine prognostische Aussage zur Hörschwellenentwicklung. Dabei wird deutlich, dass TEOAE-Resultate besonders bei der Verlaufsbeurteilung des M. Ménière gut dazu geeignet sein können, das Therapieregime zu überwachen (Monitoring) bzw. zu einer Modifikation der Behandlungsstrategie beizutragen.

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Evoked Otoacoustic Emissions from Ears with Idiopathic Sudden Deafness

Cited by 29 publications

References 6 publications

Distortion Product Otoacoustic Emissions as a Prognostic Factor for Idiopathic Sudden Sensorineural Hearing Loss

Distortion Product Otoacoustic Emissions as a Prognostic Factor for Idiopathic Sudden Sensorineural Hearing Loss

Intratympanic Drug Delivery for Tinnitus Treatment

TEOAE-Messungen zur Verlaufsbeurteilung akuter kochleovestibulärer Störungen: methodische Aspekte

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