Evoked-response audibility curve of the chinchilla

Henderson, Donald; Hamernik, Roger P.; Woodford, Charles M.; Sitler, Ronald W.; Salvi, Richard

doi:10.1121/1.1914321

Cited by 74 publications

(21 citation statements)

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“…The electrodes were inserted bilaterally into the region of the IC. A ground electrode was placed in the rostral cranium (Henderson et al, 1973). The animals were allowed to recover for two weeks prior to evoked potential (EVP) testing.…”

Section: Chronic Electrode Implantationmentioning

confidence: 99%

Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla

Bielefeld

Henderson

2007

Hearing Research

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Section: Chronic Electrode Implantationmentioning

confidence: 99%

Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla

Bielefeld

Henderson

2007

Hearing Research

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Section: Inferior Colliculus Electrode Implantationmentioning

confidence: 99%

Damage and threshold shift resulting from cochlear exposure to Paraquat-generated superoxide

Bielefeld

Harris

et al. 2005

Hearing Research

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Superoxide has been implicated as a contributing factor to cochlear pathology from a number of sources, including noise and ototoxic drugs. The effects of NADPH oxidase-dependent superoxide on the cochlea were investigated in the current study using paraquat (PQ). PQ is a toxic herbicide that causes tissue damage by generating superoxide through reduction of molecular oxygen in a reaction catalyzed by NADPH oxidase. The current study examined the effects of round window PQ administration on inferior colliculus (IC) evoked potential thresholds (EVP) and hair cell damage. Using implanted IC electrodes, chinchillas were tested for IC EVP thresholds before and after PQ exposure. Ears were exposed to PQ at one of four concentrations: 10, 5, 3 mM, and vehicle control. Thresholds were increased in a dose-dependent manner, and peaked between one and seven days post-exposure. Thresholds then showed a small amount of recovery before reaching PTS by Day 22. Outer and inner hair cell losses were consistent with PTS. The similarities between PQ ototoxicity and noise-induced hearing loss suggest the possibility of similar biochemical pathways involving superoxide.

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“…Each animal was anesthetized [IM injection of Ketamine (35 mg/kg) and Xylazine (1 mg/kg)] and made monaural by the surgical destruction of the left cochlea. During this procedure a bipolar electrode was implanted, under stereotaxic control, into the left inferior colliculus and the electrode plug cemented to the skull for the recording of the auditory evoked potential (AEP) (Henderson et al, 1973;Salvi et al, 1982). The AEP was used to estimate pure tone thresholds.…”

Section: A Auditory Evoked Potentialmentioning

confidence: 99%

The value of a kurtosis metric in estimating the hazard to hearing of complex industrial noise exposures

Qiu

Hamernik

Davis

2013

The Journal of the Acoustical Society of America

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A series of Gaussian and non-Gaussian equal energy noise exposures were designed with the objective of establishing the extent to which the kurtosis statistic could be used to grade the severity of noise trauma produced by the exposures. Here, 225 chinchillas distributed in 29 groups, with 6 to 8 animals per group, were exposed at 97 dB SPL. The equal energy exposures were presented either continuously for 5 d or on an interrupted schedule for 19 d. The non-Gaussian noises all differed in the level of the kurtosis statistic or in the temporal structure of the noise, where the latter was defined by different peak, interval, and duration histograms of the impact noise transients embedded in the noise signal. Noise-induced trauma was estimated from auditory evoked potential hearing thresholds and surface preparation histology that quantified sensory cell loss. Results indicated that the equal energy hypothesis is a valid unifying principle for estimating the consequences of an exposure if and only if the equivalent energy exposures had the same kurtosis. Furthermore, for the same level of kurtosis the detailed temporal structure of an exposure does not have a strong effect on trauma.

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Evoked-response audibility curve of the chinchilla

Cited by 74 publications

References 0 publications

Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla

Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla

Damage and threshold shift resulting from cochlear exposure to Paraquat-generated superoxide

The value of a kurtosis metric in estimating the hazard to hearing of complex industrial noise exposures

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