Evolução do carcinoma colorretal, comparando doentes com idades acima e abaixo de 40 anos, quanto à diferenciação tumoral e ao estádio do tumor

Nadal, Luís Roberto Manzione; Adachi, Caroline Terumi; Nunes, Marcus Aurelius Araujo; Ishiy, Carlos Augusto André; Bobotis, Vasilius Charilaos; Andreotti, A.; Nadal, Sidney Roberto; Bin, Fang Chia; Capelhuchnik, Peretz; Klug, Wilmar Artur

doi:10.1590/s0101-98802009000300009

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…1 In the Northern region of Portugal, it is the second most common neoplasm. 2 The clinical-pathological characteristics of the present sample were similar to those described in the literature [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] ; CRC is more frequent in men 11,15,16 and in those aged over 45 years. 11,[17][18][19][20][21] In fact, CRC is often defined as a disease of the elderly; advanced age is a risk factor for this neoplasm.…”

Section: Discussion/conclusionsupporting

confidence: 66%

Visceral obesity is not correlated with lymph node metastases nor Colorectal cancer survival

Melo

Viana

Marques

et al. 2019

Journal of Coloproctology

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Introduction The presence of lymph node metastasis in colorectal cancer is determinant for prognosis and for treatment planning. The relationship between visceral fat and the prognosis is not fully documented in the literature, so this study intended to evaluate whether there is a relationship between the presence of visceral obesity and the presence of lymph node metastases and the prognosis of patients with colorectal cancer. Materials and methods A sample of 68 patients who underwent surgery for colorectal cancer at Hospital de Braga between 1/1/2007 and 31/12/2007 was constructed, and their clinical and pathological data were recorded. Visceral fat, subcutaneous, and total fat areas were measured on preoperative computed tomography. Visceral obesity was defined as a ratio of visceral fat to total fat area >0.29. The ratio of metastatic lymph node (; number of metastatic lymph node/number of lymph node examined) was calculated. Results There was a significant association between visceral obesity and male sex ( p = 0.032). Patient survival at 5 and 10 years of follow-up was higher in patients with subcutaneous obesity in both periods, but not significant. There was a significant association between the ratio of metastatic lymph node and survival at 5 and 10 years ( p = 0.03 and p = 0.002, respectively), with higher survival when ratio of metastatic lymph node = 0% and worse for ≥ 18%. Conclusion In this study, no significant association was observed between visceral obesity and the number of metastatic lymph node, nor with survival at 5 and 10 years.

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Section: Discussion/conclusionsupporting

confidence: 66%

Visceral obesity is not correlated with lymph node metastases nor Colorectal cancer survival

Melo

Viana

Marques

et al. 2019

Journal of Coloproctology

View full text Add to dashboard Cite

show abstract

“…Em seguida, a radioterapia associada ou não à quimioterapia, é utilizada para diminuir a possibilidade de volta do tumor. 1,[5][6][7] A base do tratamento quimioterápico foi por muito tempo constituído por um único agente antineoplásico, o 5-fluoracil (5-FU), com o passar dos anos a inclusão de novos agentes ao tratamento, como ácido folínico-leucovorin (LV) nos anos 80 e o irinotecano nos anos 90, trouxe uma melhora na sobrevida dos pacientes quando comparado à monoterapia.…”

Section: Introductionunclassified

Avaliação Das Características Clínicas E Epidemiológicas E Sobrevida Global De Pacientes Portadores De Câncer Colorretal

Eisenhardt¹

2014

Rev Epidemiol Control Infect

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DESCRITORES Câncer colorretalEpidemiologia Sobrevida This study aimed to identify the epidemiological characteristic and assess overall survival in patients with CRC treated at a center specializing in oncology. Methods: Medical records of 127 patients with CRC were retrospectively evaluated. Clinical and epidemiological characteristics, in addition to treatment protocols and adverse reactions presented by patients were reviewed. The association of significance was assessed by chi-square and Fisher exact tests. The survival analyses were performed using the Kaplan-Meier method. The confidence interval was of 95% (p <0.05). Results: The mean age of patients was 60.4 years, and men were the most often affected by the disease. The survival rate at 5 years was 19.4%, being mainly influenced by the chemotherapy protocol and the presence of metastases. Conclusion: Patients with early-stage disease and that had no metastasis showed better survival prognosis. These data emphasize the importance of performing sporadic screenings, mainly in patients older than 50 years, aiming at early diagnosis of CRC and better treatment response. KEYWORDS Colorectal cancer Epidemiology Survivorship

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Clinical and epidemiological evaluation of patients with colorectal cancer from Rio Grande do Sul

F¹,

Jj²,

Eisenhardt³

et al. 2012

J. Coloproctol. (Rio J.)

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Colorectal cancer has a high incidence in Brazil, with the South and Southeast regions presenting the largest number of cases. OBJECTIVE: Identify the epidemiological characteristics and the regimens used as first-line treatment of patients with colorectal cancer treated at a cancer center in Santa Cruz do Sul (RS, Brazil) from 2006 to 2011. METHODS: The records of 130 patients were retrospectively evaluated. Clinical and epidemiological characteristics, such as age, gender, ethnic group, stage of disease, primary site of disease and first-line treatment, were evaluated. The association of significance was evaluated using the chi-square and Fischer exact tests. The confidence interval used was 95% (p<0.05). RESULTS: The mean age of patients with colorectal cancer in this study was 60.8 years, with higher incidence of the disease in men. At diagnosis, 40% of the patients had advanced disease stage IV. The regimen of 5-fluorouracil/folic acid (68.5%) was used as first-line treatment. CONCLUSION: This study showed high prevalence of colorectal cancer in patients of advanced age with the diagnosis made in the later stage of the disease. This fact demonstrates the importance of prevention campaigns that encourage periodic examinations in patients over 50 years of age.
No Brasil, o câncer colorretal apresenta uma elevada incidência, sendo as Regiões Sul e Sudeste as com maior número de casos. OBJETIVO: Identificar as características epidemiológicas e os esquemas terapêuticos utilizados como primo-tratamento dos pacientes portadores de câncer colorretal atendidos em um centro especializado em oncologia em Santa Cruz do Sul (RS) no período de 2006 a 2011. MÉTODO: Foram avaliados retrospectivamente 130 prontuários de pacientes portadores de câncer colorretal. Características clínicas e epidemiológicas como idade, sexo, cor da pele, estádio da doença, sítio primário da doença e primo-tratamento foram avaliadas. A associação de significância foi avaliada pelos testes do qui-quadrado e exato de Fischer. O intervalo de confiança utilizado foi de 95% (p<0,05). RESULTADOS: A idade média dos pacientes encontrada neste estudo foi de 60,8 anos com incidência maior da doença entre os homens. No momento do diagnóstico, 40% dos pacientes estavam com a doença no estádio IV. Como primo-tratamento o esquema terapêutico mais utilizado foi o 5-fluoracil/ácido folínico (68,5%). CONCLUSÃO: Este estudo ratificou a alta prevalência do câncer colorretal em pacientes com idade mais avançada, com o diagnóstico realizado na fase mais avançada da doença. Esse fato evidencia a importância da realização de campanhas de prevenção que estimulem a realização de exames periódicos nos pacientes com idade acima de 50 anos

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Evolução do carcinoma colorretal, comparando doentes com idades acima e abaixo de 40 anos, quanto à diferenciação tumoral e ao estádio do tumor

Cited by 5 publications

References 21 publications

Visceral obesity is not correlated with lymph node metastases nor Colorectal cancer survival

Visceral obesity is not correlated with lymph node metastases nor Colorectal cancer survival

Avaliação Das Características Clínicas E Epidemiológicas E Sobrevida Global De Pacientes Portadores De Câncer Colorretal

Clinical and epidemiological evaluation of patients with colorectal cancer from Rio Grande do Sul

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