Introduction: Caudal Regression Syndrome (CRS) is an association of rectal, genitourinary, lumbosacral, and lower extremities anomalies with an extensive spectrum of presentations. As an early misdevelopment phenomenon, anatomical findings in this anomaly are vast, so individualized surgical treatment should be planned.
Methods:Between January 2010 and December 2021, medical charts of patients with anorectal malformation (ARM), lumbosacral or spinal cord anomalies, lower extremities, and genitourinary malformation were retrospectively reviewed. Demographic and clinical features were identified, and urological procedures performed in each patient, including urinary and bowel stomas, were described.Cases presentation: Among 288 ARM patients, 19 (6,6%) were identified. Anorectal agenesis without fistula was the most frequent type of ARM (21,0%). Renal dysplasia and renal hypotrophy were found in 6 (31,5%).Conclusions: CRS requires a multidisciplinary approach and early identification of patients with high intestinal obstruction and renal failure risk. The surgical team may have skills regarding complex organs and systems reconstruction.