Objective In the digital age, eHealth is vital in modern healthcare, impacting medical services and public health. Despite its potential in disease management, a comprehensive bibliometric analysis is lacking. This study utilizes bibliometric methods to explore the evolution of eHealth in disease management from 1999 to 2023, aiming to discern the research status and trends. Methods A literature search was conducted using the Web of Science Core Collection (WOSCC) database. Publications and journals were quantitatively analyzed using Microsoft Office Excel 2023. Country/institution/author collaborations and keyword co-occurrences were analyzed using VOSviewer. CiteSpace was employed to analyze the citation bursts of reference. A global distribution network of publications was constructed and thematic trends were analyzed using R package “bibliometrix.” Results The study identified 1763 articles on eHealth in disease management. Since 2011, there has been a notable increase in publications, with the United States (n = 391, 22.08%) and the University of Sydney (n = 60, 3.40%) as leading contributors. High-quality journals primarily publish this research. Globally, 9631 authors contributed, with Chavannes, Niels H being the most prolific (n = 23). Author co-citation analysis indicated Eysenbach, G as the most cited (n = 336). Research currently focuses on developing a comprehensive eHealth framework, optimizing mHealth for chronic diseases, improving eHealth intervention trial reporting, assessing social factors in eHealth literacy, and examining telemedicine's role during the Covid-19 pandemic. Conclusion This study offers a comprehensive overview of eHealth research in disease management. eHealth's potential in disease prevention and treatment is significant. To enhance eHealth's impact, international collaboration, technological innovation, tailored intervention trials, addressing the digital divide, and solving legal and ethical issues are crucial. This study will guide future research endeavors, with the goal of enhancing eHealth's benefits and expanding its accessibility to a wider patient base.