Evolution and predictors of morphological and functional arterial changes in the course of type 1 diabetes mellitus

Vastagh, Ildikó; Horváth, Tamás; G, Nagy; Varga, Tímea; Juhász, Eszter; Juhász, Vencel; Kollai, Márk; Bereczki, Dániel; Somogyi, Anikó

doi:10.1002/dmrr.1133

Cited by 16 publications

(15 citation statements)

References 39 publications

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“…Recently, structural changes in the carotid arteries of type 1 diabetics without overt vascular disease were examined according to age and the duration of diabetes [9]. The researchers found that intima-media thickness was one of the first parameters to change in the diabetic population.…”

Section: Discussionmentioning

confidence: 99%

“…Several factors are important in predicting the advancement of aortic dysfunction in people with diabetes. Age is one of the most important, as it is an independent predictor of stiffness and pulse wave velocity [9]. In addition, the duration of diabetes predicts the intima-media cross-sectional area and systolic blood pressure [9].…”

Section: Discussionmentioning

confidence: 99%

“…Age is one of the most important, as it is an independent predictor of stiffness and pulse wave velocity [9]. In addition, the duration of diabetes predicts the intima-media cross-sectional area and systolic blood pressure [9]. However, if a person with type 1 diabetes maintains tight glycemic control, arterial elastic properties can be improved [33].…”

Section: Discussionmentioning

confidence: 99%

“…Stiffness changes associated with diabetes predominantly affect the aorta and the proximal arteries. Accordingly, the carotid-aorto-femoral pulse wave velocity was highly correlated with the duration of type 1 diabetes in humans [9]. This loss of vascular compliance is a powerful predictor of cardiovascular and all-cause mortality for people with diabetes [10].…”

Section: Introductionmentioning

confidence: 99%

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Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes

Searls

Smirnova

VanHoose

et al. 2012

Experimental Diabetes Research

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Vascular complications are associated with the progressive severity of diabetes, resulting in significant morbidity and mortality. This study quantifies functional vascular parameters and macrovascular structure in a rat model of type 1 diabetes. While there was no difference in the systemic arterial elastance (Ea) with 50 days of diabetes, changes were noted in the aorta and femoral artery including increased tunica media extracellular matrix content, decreased width of both the media and individual smooth muscle cell layers, and increased incidence of damaged mitochondria. Extracellular matrix proteins and elastin levels were significantly greater in the aorta of diabetic animals. These differences correlated with diminished matrix metalloprotease activity in the aorta of the diabetic animals. In conclusion, diabetes significantly altered the structure and ultrastructure of the aorta and femoral artery before systemic changes in arterial elastance could be detected.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes

Searls

Smirnova

VanHoose

et al. 2012

Experimental Diabetes Research

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“…Yavuz et al (26) and Gunczler et al (27) found no increase of CA-IMT in children with type 1 DM. However, Yamasaki et al (28) Jarvisalo et al (29) and Vastagh I et al (30) reported that CA-IMT values were significantly higher in children with type 1 DM. Jarvisalo et al (29) also showed that type 1 DM was an independent risk factor for high CA-IMT.…”

Section: Discussionmentioning

confidence: 97%

Association Between Apolipoprotein E Polymorphism and Subclinic Atherosclerosis in Patients with Type 1 Diabetes Mellitus

Atabek¹,

Özkul²,

Eklioğlu³

et al. 2012

jcrpe

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Objective The most important cause of morbidity and mortality in type 1 diabetes mellitus (DM) is atherosclerosis. Apolipoprotein E (Apo E) polymorphism is accused of being the genetic risk factor for atherosclerosis. The aim of the present study was to determine which Apo E polymorphism was related to atherosclerosis in patients with type 1 DM.Methods: Seventy-four patients with type 1 DM were enrolled in the study. Age, diabetes duration, daily insulin dose, microalbuminuria, and major cardiovascular risk factors including anthropometric and metabolic parameters were assessed in each patient. Non-invasive ultrasonographic measurements were also performed. For determination of Apo E genotype, DNA was extracted from venous blood from all subjects using standard methods. Apo E genotyping was performed using a PCR–restriction fragment-length polymorphism assay.Results: Systolic blood pressure and carotid artery intima-media thickness (CA-IMT) were increased in subjects with E4/E4 polymorphism. According to univariate analysis, when adjusted for all risk factors, genotypes did not differ for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides (p>0.05). However, E3/E3, E3/E4 and E4/E4 genotypes were found to be associated with an increase in CA-IMT (p<0.001).Conclusions: Our results suggest that the polymorphism associated with atherosclerosis in type1 DM is Apo E4/E4.Conflict of interest:None declared.

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Pulse wave reflection is associated with diabetes duration, albuminuria and cardiovascular disease in type 1 diabetes

et al. 2014

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Evolution and predictors of morphological and functional arterial changes in the course of type 1 diabetes mellitus

Abstract: There are differences in the time course of evolution and in predictors of morphological and functional changes in arteries in type 1 diabetes mellitus.

Cited by 16 publications

References 39 publications

Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes

Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes

Association Between Apolipoprotein E Polymorphism and Subclinic Atherosclerosis in Patients with Type 1 Diabetes Mellitus

Pulse wave reflection is associated with diabetes duration, albuminuria and cardiovascular disease in type 1 diabetes

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