Evolution of Angioplasty Devices

King, Martin W.; Bambharoliya, Tushar; Ramakrishna, Harshini; Zhang, Fan

doi:10.1007/978-3-030-42443-5_6

Cited by 3 publications

(4 citation statements)

References 58 publications

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“…Since Andreas Grüntzig successfully performed the first PTCA in 1977 [ 2 ], there have been numerous advancements in percutaneous coronary interventions (PCI) [ 3 – 5 ] and the general understanding of coronary artery disease [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…The first balloons for PTCA were manufactured from soft materials like flexible polyvinyl chloride (PVC) [ 2 ]. Nevertheless, the necessity for thick walls resulted in the development of large-profile balloons [ 3 ], posing a challenge when delivering them to the target lesion. By introducing new materials like polyethylene terephthalate (PET) and nylon [ 3 ], the size and profile of PTCA balloons have decreased, allowing improved lesion crossing, more precise placement, and maneuverability within the vessel.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the necessity for thick walls resulted in the development of large-profile balloons [ 3 ], posing a challenge when delivering them to the target lesion. By introducing new materials like polyethylene terephthalate (PET) and nylon [ 3 ], the size and profile of PTCA balloons have decreased, allowing improved lesion crossing, more precise placement, and maneuverability within the vessel. Besides the diameter and wall thickness (WT), the choice of material also influences the compliance of the balloons.…”

Section: Introductionmentioning

confidence: 99%

“…In 1982, over-the-wire technology was introduced [ 13 ]. This technology allows a GW to pass through the entire catheter, be independently manipulated [ 3 ], and allows the physician to leave the GW in place even when exchanging the balloon catheter. However, two operators were required due to the required length of the GW (approximately 300 cm), resulting in longer treatment durations and the risk of contamination of the GW.…”

Section: Introductionmentioning

confidence: 99%

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Design of percutaneous transluminal coronary angioplasty balloon catheters

Amstutz,

Behr,

Krebs

et al. 2023

BioMed Eng OnLine

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Background Eight commercially available percutaneous transluminal coronary angioplasty (PTCA), including semi-compliant and non-compliant balloons, have been assessed in detail on their tip, balloon, shaft, RX-Port, and hypotube design. Important performance characteristics such as tip deformation, balloon elongation, and deflation rate have been quantified. Methods Five catheters of each model were evaluated during various tests. The robustness of the tips was evaluated through compression, measuring any occurrence of damage. The longitudinal growth of the balloons was recorded during inflation up to Rated Burst Pressure (RBP). The forces required to move the catheter forward and retract it into the guide catheter were measured in a simulated use test setup. The deflation behavior was studied by measuring extracted contrast media over time. Furthermore, balloon compliance and catheter dimensions were investigated. Results The outer dimensions of the catheter were found to be smallest at the hypotube (0.59–0.69 mm) and highest at the balloon, respectively, the crossing profile (0.9–1.2 mm). The tip diameter increased after compression by 1.7–22%. Cross-sections of the folded balloons revealed a tri- and two-fold, respectively. The measured balloon elongation ranged from 0.6 to 2.0 mm. After the inflation of the balloon, an increase in friction between the guide wire and the catheter was observed on four catheters. A maximum increase of 0.12 N to 1.07 N was found. Cross-sections of the RX-Port revealed a semicircular-shaped inflation lumen and a circular guide wire lumen. The measured deflation rate ranged from 0.004 to 0.013 µL/s, resulting in an estimated balloon deflation time of 10.2–28.1 s. Conclusion This study provides valuable insights into the design characteristics of RX PTCA balloon catheters, which can contribute to facilitating the development of improved catheter designs and enhancing clinical outcomes. Distinctions between SC and NC catheters, such as balloon performance and dimensions, are evident. It is important to note that no single catheter excels in all aspects, as each possesses unique strengths. Therefore, it is essential to consider individual intervention requirements when selecting a catheter. The research also identifies specific catheter weaknesses, such as reduced wall thickness, fringes at the tip, and reduced performance characteristics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Design of percutaneous transluminal coronary angioplasty balloon catheters

Amstutz,

Behr,

Krebs

et al. 2023

BioMed Eng OnLine

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Immunomodulation Strategies for the Successful Regeneration of a Tissue‐Engineered Vascular Graft

Zhang

King

2022

Adv Healthcare Materials

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Cardiovascular disease leads to the highest morbidity worldwide. There is an urgent need to solve the lack of a viable arterial graft for patients requiring coronary artery bypass surgery. The current gold standard is to use the patient's own blood vessel, such as a saphenous vein graft. However, some patients do not have appropriate vessels to use because of systemic disease or secondary surgery. On the other hand, there is no commercially available synthetic vascular graft available on the market for small diameter (<6 mm) blood vessels like coronary, carotid, and peripheral popliteal arteries. Tissue-engineered vascular grafts (TEVGs) are studied in recent decades as a promising alternative to synthetic arterial prostheses. Yet only a few studies have proceeded to a clinical trial. Recent studies have uncovered that the host immune response can be directed toward increasing the success of a TEVG by shedding light on ways to modulate the macrophage response and improve the tissue regeneration outcome. In this review, the basic concepts of vascular tissue engineering and immunoengineering are considered. The state-of-art of TEVGs is summarized and the role of macrophages in TEVG regeneration is analyzed. Current immunomodulatory strategies based on biomaterials are also discussed.

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A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of α, β, and α + β. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. Graphic abstract

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Evolution of Angioplasty Devices

Cited by 3 publications

References 58 publications

Design of percutaneous transluminal coronary angioplasty balloon catheters

Design of percutaneous transluminal coronary angioplasty balloon catheters

Immunomodulation Strategies for the Successful Regeneration of a Tissue‐Engineered Vascular Graft

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

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